- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: CYP3A7
Gene name: cytochrome P450, family 3, subfamily A, polypeptide 7
HGNC ID: 2640
Synonyms: CP37, P450-HFLA
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CYP19A1 | 1 hits |
| 2 | CYP1A1 | 1 hits |
| 3 | CYP1A2 | 1 hits |
| 4 | CYP27B1 | 1 hits |
| 5 | CYP2C19 | 1 hits |
| 6 | CYP2D6 | 1 hits |
| 7 | CYP2E1 | 1 hits |
| 8 | CYP3A4 | 1 hits |
| 9 | CYP3A5 | 1 hits |
| 10 | NFKB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16375696 | Cytochrome P450 (CYP) is a group of enzymes that metabolize drugs to a more water-soluble form, rendering them available for renal excretion. |
| 2 | 16375696 | Nearly 50% of all medications currently on the market are metabolized by the enzyme CYP3A4, while metabolism of another 35-40% occurs through enzymes CYP1A2, CYP2C19, CYP2D6, CYP3A5 CYP3A6, and CYP3A7. |
| 3 | 19275551 | Role of NF-kappaB in the regulation of cytochrome P450 enzymes. |
| 4 | 19275551 | Nuclear factor kappa B (NF-kappaB) is an important transcription factor that regulates a wide spectrum of genes including cytochrome P450 (CYP), the most important family of drug metabolizing enzymes. |
| 5 | 19275551 | Therefore, in this review, we addressed the potential role of NF-kappaB in CYP regulation. |
| 6 | 19275551 | We proposed three mechanisms by which NF-kappaB can regulate CYP expression and activity. |
| 7 | 19275551 | First, NF-kappaB can directly regulate the expression of CYP1A1, CYP2B1/2, CYP2C11, CYP2D5, CYP2E1, CYP3A7, and CYP27B1 through binding to the promoter region of these genes. |
| 8 | 19275551 | Second, NF-kappaB indirectly regulates the transcription of CYP genes through mutual repression with some nuclear receptors that are involved in CYP regulation such as AhR, CAR, GR, PXR, RXR, PPAR, FXR, and LXR. |
| 9 | 19275551 | Finally, NF-kappaB can regulate CYP activity at post-transcriptional level by inducing heme oxygenase or by affecting the CYP protein stability. |
| 10 | 19275551 | Therefore, we propose that NF-kappaB could be one of the links between inflammation, oxidative stress, and CYP regulation in these diseases. |
| 11 | 19275551 | In conclusion, NF-kappaB plays a crucial role in the regulation of CYP through several mechanisms and this role can explain the altered CYP regulation in many conditions. |
| 12 | 23583279 | Rising activities of placental CYP19A1 and oxidative isoforms of HSD17B, and of fetal CYP3A7 with advancing gestation may protect the fetus from hyperestrogenization. |