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Gene Information
Gene symbol: DCXR
Gene name: dicarbonyl/L-xylulose reductase
HGNC ID: 18985
Synonyms: KIDCR, DCR, SDR20C1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADH1A | 1 hits |
| 2 | AKR1B1 | 1 hits |
| 3 | CBR1 | 1 hits |
| 4 | GSTA1 | 1 hits |
| 5 | PGF | 1 hits |
| 6 | PTGES | 1 hits |
| 7 | SPAG8 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 1900532 | It was greater than 4000X more potent in its inhibition of rat lens aldose reductase than the closely related rat or pig kidney aldehyde reductase, thus making it the most selective inhibitor of a NADPH-dependent carbonyl reductase identified to date. |
| 2 | 16931029 | Aldose reductase (AKR1B1; ALR2; E.C. 1.1.1.21) is an NADPH-dependent carbonyl reductase which has long been associated with complications resulting from the elevated blood glucose often found in diabetics. |
| 3 | 16931029 | To address this problem, a library of bead-immobilized compounds was screened against fluorescently labeled aldose reductase in the presence of fluorescently labeled aldehyde reductase, a non-target enzyme, to identify compounds which were aldose reductase specific. |
| 4 | 17570531 | These enzymes include aldehyde dehydrogenases (ALDH), aldo-keto reductases (AKR), carbonyl reductase (CBR), and glutathione S-transferases (GST). |
| 5 | 18484512 | The downstream enzymes in PG synthesis pathway are: microsomal PGE synthase-1 (mPGES-1), PGF synthase (PGFS) and prostaglandin 9-ketoreductase/carbonyl reductase (CBR1) which catalyzes conversion of PGE 2 into PGF2 alpha. |
| 6 | 18484512 | In contrast to mPGES-1, endometrial PGFS is highly increased on days 13-15 similarly as CBR1 on days 16-17 of the estrous cycle. |
| 7 | 18484512 | It may be result of high expression of mPGES-1 in trophoblast and endometrium on days 10-13 of pregnancy and simultaneously the down-regulation of PGFS and CBR1 in conceptuses during this period. |
| 8 | 23804523 | Previous experiments using microsomal preparations and the nonspecific inhibitor glycyrrhetinic acid suggested a role for 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in the formation of both erythro- and threohydrobupropion. 11β-HSD1 catalyzes the conversion of inactive glucocorticoids (cortisone, prednisone) to their active forms (cortisol, prednisolone). |
| 9 | 23804523 | The formation of erythrohydrobupropion was not altered in experiments with microsomes from 11β-HSD1-deficient mice or upon incubation with 11β-HSD1 inhibitor, indicating the existence of another carbonyl reductase that generates erythrohydrobupropion. |