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Gene Information
Gene symbol: DDHD2
Gene name: DDHD domain containing 2
HGNC ID: 29106
Synonyms: KIAA0725, SPG54
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BICC1 | 1 hits |
| 2 | DGKB | 1 hits |
| 3 | FBL | 1 hits |
| 4 | IKBKB | 1 hits |
| 5 | INS | 1 hits |
| 6 | NCAM1 | 1 hits |
| 7 | NFKB1 | 1 hits |
| 8 | SRF | 1 hits |
| 9 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9716918 | Imbalances in N-CAM, SAM and polysialic acid may underlie the paranodal ion channel barrier defect in diabetic neuropathy. |
| 2 | 10835359 | The structure of the MEF2S domain is entirely different from that of the equivalent SAM domain in SRF and MCM1, accounting for the absence of cross-reactivity with other proteins that interact with these transcription factors. |
| 3 | 20208423 | S-Adenosyl-L-methionine ameliorates TNFalpha-induced insulin resistance in 3T3-L1 adipocytes. |
| 4 | 20208423 | The IkappaB kinase-beta (IKK-beta)/ nuclear factor-kappaB (NF-kappaB) pathway is a molecular mediator of insulin resistance. |
| 5 | 20208423 | We investigated the effects of SAM on the glucose transport and insulin signaling impaired by the tumor necrosis factor alpha (TNFalpha) in 3T3-L1 adipocytes. |
| 6 | 20208423 | SAM partially reversed the basal and insulin stimulated glucose transport, which was impaired by TNFalpha. |
| 7 | 20208423 | The TNFalpha-induced suppression of the tyrosine phosphorylation of the insulin receptor substrate-1 (IRS-1) and Akt in 3T3-L1 adipocytes was also reversed by SAM. |
| 8 | 20208423 | In addition, SAM significantly attenuated the TNFalpha-induced degradation of IkappaB-alpha and NF-kappaB activation. |
| 9 | 20208423 | These results suggest that SAM can alleviate TNFalpha mediated-insulin resistance by inhibiting the IKK-beta/NF-kappaB pathway and thus can have a beneficial role in the treatment of type 2 diabetes mellitus. |
| 10 | 21922595 | Bicaudal C homologue 1 (Bicc1) knockout in mice causes polycystic kidney disease and pancreas development defects, including a reduction in insulin-producing β-cells and ensuing diabetes. |
| 11 | 21922595 | In mice, Bicc1 blocks canonical Wnt signaling, mostly via its SAM domain. |
| 12 | 22869109 | Furthermore, comparison of A. pernix fibrillarin with homologous structures revealed different orientations of Phe110 and changes in α-helix 6 of fibrillarin and suggests key differences in its interactions with the adenine ring of SAM in the active site and with the C/D RNA. |
| 13 | 22974639 | The type II diacylglycerol kinases (DGKs) contain several functional domains such as a pleckstrin homology (PH) domain, two C1 domains and a sterile α-motif (SAM) domain. |
| 14 | 22974639 | Moreover, a high extracellular concentration of glucose activated DGKδ in skeletal muscle cells, which was followed by a reduction in the intracellular diacylglycerol levels and the inactivation of protein kinase Cα, the enzyme that phosphorylates and inactivates the insulin receptor. |