- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: DEFB1
Gene name: defensin, beta 1
HGNC ID: 2766
Synonyms: HBD-1, DEFB-1, DEFB101, HBD1, BD1, MGC51822
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CCK | 1 hits |
| 2 | CDK4 | 1 hits |
| 3 | INS | 1 hits |
| 4 | LEP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11340353 | BD-1 gene expressions in the kidneys of diabetic rodent models, cholecystokinin-insensitive Otsuka Long-Evans Tokushima Fatty rats, leptin-insensitive obese (fa/fa) Wistar rats, and db/db mice, were significantly lower than those of their lean littermates. |
| 2 | 14521940 | DNA sequencing revealed that CDK4 represents the rat beta defensin-1 gene (rBD-1). rBD-1 mRNA was detected in rat kidney, heart, lung, and skeletal muscle using RT-PCR. |
| 3 | 14521940 | Biglycan and TGF-beta1 mRNAs were significantly up-regulated in kidneys of GK rats at 26 weeks compared to 16 and 6 weeks, showing that the kidneys of GK rats mimic the gene expression pattern described for human and experimental DN. |
| 4 | 16740310 | To study the functionality of the innate immune system during diabetes, we measured the expression levels of rat beta-defensin 1 (rBD-1), rBD-2, rTLR2, and rTLR4 in the kidney, lung, liver, and brain of streptozotocin-induced diabetic rats with and without insulin treatment. |
| 5 | 18178160 | Increasing concentrations of glucose enhanced hBD-1 expression and these levels were further elevated after insulin treatment. |
| 6 | 18178160 | Insulin treatment also led to the up-regulation of human sodium/glucose transporter 1 (hSGLT1), which further increases intracellular glucose levels. |
| 7 | 18178160 | Thus, our findings suggest for the first time that insulin signaling is important for hBD-1 optimal expression by elevating intracellular glucose levels and by mediating gene expression. |
| 8 | 18178160 | Increasing concentrations of glucose enhanced hBD-1 expression and these levels were further elevated after insulin treatment. |
| 9 | 18178160 | Insulin treatment also led to the up-regulation of human sodium/glucose transporter 1 (hSGLT1), which further increases intracellular glucose levels. |
| 10 | 18178160 | Thus, our findings suggest for the first time that insulin signaling is important for hBD-1 optimal expression by elevating intracellular glucose levels and by mediating gene expression. |