Ignet

Gene Information

Gene symbol: DIRAS3

Gene name: DIRAS family, GTP-binding RAS-like 3

HGNC ID: 687

Synonyms: NOEY2

Related Genes

#	Gene Symbol	Number of hits
1	ACE	1 hits
2	AGT	1 hits
3	AKT1	1 hits
4	EGF	1 hits
5	EGFR	1 hits
6	ERBB2	1 hits
7	HRAS	1 hits
8	IGF2R	1 hits
9	INS	1 hits
10	KRAS	1 hits
11	MAPK3	1 hits
12	MEST	1 hits
13	PTH	1 hits
14	RET	1 hits

Related Sentences

#	PMID	Sentence
1	1639936	Analyses on tumor DNA from one case of PC and one of atypical adenoma showed no evidence of ras gene mutations, PTH gene rearrangement, or allelic loss from chromosome 11q13 (locus of the gene for multiple endocrine neoplasia type 1).
2	2181284	The females carrying the insulin-promoted ras gene did not manifest any of the physiological abnormalities observed in males and showed only minor histological and ultrastructural changes, even at much greater ages.
3	3014147	The linked polymorphic loci 5' to the insulin gene and 3' to the c-Harvey-ras-1 (c-Ha-ras) gene, both localised to the short arm of chromosome 11, have been studied in 14 type I diabetic pedigrees.
4	8462284	Insulin induction of c-Ki-ras in rat liver and in cultured normal rat hepatocytes.
5	8462284	Insulin administration in neonatal rats causes a dramatic accumulation of the major c-Ki-ras transcript. 2.
6	8462284	Injection of insulin in alloxan-induced diabetic rats is able to restore almost completely the level of c-Ki-ras transcript found in insulin-induced normal rats. 4.
7	8462284	Results from nuclear run-off experiments reveal that the inductive effect of insulin is at the level of transcription of the c-Ki-ras gene. 5.
8	8462284	As in whole animals, insulin is also able to induce the expression of c-Ki-ras in cultured normal hepatocytes. 6.
9	8462284	This inductive effect of insulin is markedly reduced in hepatocytes which have been previously treated with the tumour promoter, 12-O-tetradecanoylphorbol-13 acetate for 24 hr, a result suggesting that at least part of the effect of insulin is mediated via protein kinase C.
10	16386515	We studied two RAS gene polymorphisms: the angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGTM235T).
11	16386515	The distributions of genotypes were ACE DD, ID, II: 33%, 48%, 19%; and AGT TT, MT, MM: 15%, 45%, 40%, respectively.
12	16386515	ACE D and AGT T alleles may be implicated in glucose metabolism disorders after transplantation.
13	19521719	We identified no mutations in ZFP57, KCNJ11, ABCC8, GCK, HNF1A, HNF1B, HNF3B, IPF1, PAX4, or ZIC3.
14	19521719	The proband had loss of methylation at the 6q24 locus TNDM and also at the loci IGF2R, DIRAS3, and PEG1, while the other family members, including the healthy monozygotic twin, had normal findings.
15	23213974	The most common mutations involve K-ras gene, epidermal growth factor (EGF-R) and HER2 gene.
16	23213974	Loss of function of tumor-suppressor genes has been documented in pancreatic cancer, especially in CDKN2a, p53, DPC4 and BRCA2 genes.
17	23934677	Functional significance of the novel H-RAS gene mutation M72I in a patient with medullary thyroid cancer.
18	23934677	Though usually sporadic, 1 in 4 cases are of genetic origin, with germinal mutations in the RET proto-oncogene in familial forms and somatic mutations both in RET and in the RAS family genes in sporadic ones.This study aimed to characterize a rare H-RAS sequence variant -M72I- in a patient with sporadic MTC, focusing on its functional significance.Mutation analysis was performed for the RET, N-RAS, K-RAS and H-RAS genes by direct sequencing.
19	23934677	Western blot analysis was done on 4 thyroid tissues from 1 patient carrying the M72I mutation in H-RAS, 1 with the Q61R mutation in H-RAS, 1 with no RET, H-RAS, K-RAS or N-RAS gene mutations, and 1 normal thyroid, using different antibodies against Erk1/2, phospho-Erk1/2 (Thr202/Tyr204), Akt and phospho-Akt (Ser473).
20	23934677	Large-scale molecular dynamics simulations were completed for H-RAS wt and H-RAS M72I.Western blot analysis demonstrated that both MAPK and PI3K/Akt pathways were activated in the MTC patient carrying the M72I variant.
21	23934677	Results of molecular dynamics were consistent with Western blot experiments.The M72I mutation may contribute effectively to proliferation and survival signaling throughout the MAPK and PI3K/Akt pathways.
22	23934677	Functional significance of the novel H-RAS gene mutation M72I in a patient with medullary thyroid cancer.
23	23934677	Though usually sporadic, 1 in 4 cases are of genetic origin, with germinal mutations in the RET proto-oncogene in familial forms and somatic mutations both in RET and in the RAS family genes in sporadic ones.This study aimed to characterize a rare H-RAS sequence variant -M72I- in a patient with sporadic MTC, focusing on its functional significance.Mutation analysis was performed for the RET, N-RAS, K-RAS and H-RAS genes by direct sequencing.
24	23934677	Western blot analysis was done on 4 thyroid tissues from 1 patient carrying the M72I mutation in H-RAS, 1 with the Q61R mutation in H-RAS, 1 with no RET, H-RAS, K-RAS or N-RAS gene mutations, and 1 normal thyroid, using different antibodies against Erk1/2, phospho-Erk1/2 (Thr202/Tyr204), Akt and phospho-Akt (Ser473).
25	23934677	Large-scale molecular dynamics simulations were completed for H-RAS wt and H-RAS M72I.Western blot analysis demonstrated that both MAPK and PI3K/Akt pathways were activated in the MTC patient carrying the M72I variant.
26	23934677	Results of molecular dynamics were consistent with Western blot experiments.The M72I mutation may contribute effectively to proliferation and survival signaling throughout the MAPK and PI3K/Akt pathways.