Ignet

Gene Information

Gene symbol: DLL4

Gene name: delta-like 4 (Drosophila)

HGNC ID: 2910

Related Genes

#	Gene Symbol	Number of hits
1	BRD2	1 hits
2	BTC	1 hits
3	CD4	1 hits
4	DLL1	1 hits
5	FOXP3	1 hits
6	HBB	1 hits
7	IGF1	1 hits
8	IGFBP1	1 hits
9	IGFBP3	1 hits
10	IL2RA	1 hits
11	INHBE	1 hits
12	INS	1 hits
13	MAPK3	1 hits
14	NEUROG3	1 hits
15	NGF	1 hits
16	PPARA	1 hits
17	PPARD	1 hits
18	PPARG	1 hits
19	PRL	1 hits
20	SHBG	1 hits
21	SYP	1 hits

Related Sentences

#	PMID	Sentence
1	1682196	Hexamethonium markedly reduced the ANS response to insulin injection (delta EPI +2130 +/- 600 pM, P less than 0.025 vs. control) despite a similar fall of plasma glucose (delta -4.1 +/- 0.2 mM) and a lower nadir (0.6 +/- 0.1 mM).
2	4053413	The amenorrhoeic diabetics in contrast had significantly lower serum concentrations of SHBG, 5 alpha-dihydrotestosterone and free and total oestradiol-17 beta than either group of menstruating women (P less than 0.05), and significantly lower concentrations of delta 4-androstenedione (P less than 0.01), dehydroepiandrosterone sulphate (P less than 0.01), testosterone (P less than 0.01), and oestrone (P less than 0.05), than the cycling diabetics.
3	8146207	We examined the delta 4 (n-6) desaturation and the fatty acid composition of liver microsomes in the insulin-dependent spontaneously diabetic Wistar Bio-Breeding (BB) rat.
4	9408741	Elevated levels of sex hormones and sex hormone binding globulin in male patients with insulin dependent diabetes mellitus.
5	9408741	Levels of free-testosterone (0.41 +/- 0.04 nmol/l), oestrone (0.33 +/- 0.03 nmol/l), oestradiol (0.14 +/- 0.01 nmol/l), delta 4-androstenedione (4.44 +/- 0.43 vs 3.85 +/- 0.42 nmol/l), and prolactin (249 +/- 24 vs 200 +/- 19 mIU/l) increased compared to values obtained before regulation (all p < 0.05).
6	9431819	The aim of the present study was to assess the effect of streptozotocin diabetes and insulin treatment on adrenic acid delta4 desaturation and fatty acid composition of liver microsomes in Wistar rats fed a fat free semi-synthetic basal diet supplemented with 10% EPA-rich marine oil.
7	9431819	Insulin treatment with 2.0 I.U./100 g body weight-1 twice a day for 3 days resulted in hypoglycemia and suppressed both the increased delta4 n-6 desaturation and 22:6n-3/22:5n-3 ratio.
8	9431819	The aim of the present study was to assess the effect of streptozotocin diabetes and insulin treatment on adrenic acid delta4 desaturation and fatty acid composition of liver microsomes in Wistar rats fed a fat free semi-synthetic basal diet supplemented with 10% EPA-rich marine oil.
9	9431819	Insulin treatment with 2.0 I.U./100 g body weight-1 twice a day for 3 days resulted in hypoglycemia and suppressed both the increased delta4 n-6 desaturation and 22:6n-3/22:5n-3 ratio.
10	12240900	Basal serum GH, GH-binding protein (GHBP), IGF-I, IGF-binding protein-3 (IGFBP-3) levels were determined as well as GH levels during GHRH stimulation.
11	12240900	In addition, basal serum androgens [free T (FT), delta4 and DHEAS], insulin and glucose levels were determined.
12	12403815	The present study demonstrates that adult human pancreatic duct cells can be converted into insulin-expressing cells after ectopic, adenovirus-mediated expression of the class B basic helix-loop-helix factor neurogenin 3 (ngn3), which is a critical factor in embryogenesis of the mouse endocrine pancreas.
13	12403815	Infection with adenovirus ngn3 (Adngn3) induced gene and/or protein expression of NeuroD/beta2, Pax4, Nkx2.2, Pax6, and Nkx6.1, all known to be essential for beta-cell differentiation in mouse embryos.
14	12403815	Expression of ngn3 in adult human duct cells induced Notch ligands Dll1 and Dll4 and neuroendocrine- and beta-cell-specific markers: it increased the percentage of synaptophysin- and insulin-positive cells 15-fold in ngn3-infected versus control cells.
15	12403815	Infection with NeuroD/beta2 (a downstream target of ngn3) induced similar effects.
16	12466359	Insulin sensitivity and the insulin-like growth factor system in prepubertal boys with premature adrenarche.
17	12466359	Fasting levels of glucose, insulin, proinsulin (P(0)), hemoglobin A1c, testosterone, SHBG, delta4-androstenedione, dehydroepiandrosterone sulfate, LH, FSH, IGF-I, IGF-binding protein-1, IGF-binding protein-3, free IGF-I, and lipids were measured.
18	12466359	Total IGF-I, P(0), ratio of P(0) and fasting insulin level, and log insulin area under the curve were higher, and SHBG was lower in the boys with PA, compared with controls.
19	17303930	Conophylline and betacellulin-delta4: an effective combination of differentiation factors for pancreatic beta cells.
20	17303930	Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and betacellulin, respectively.
21	17303930	We examined the effect of conophylline and betacellulin-delta4 on beta cell differentiation.
22	17303930	In AR42J cells, conophylline and betacellulin-delta4 converted them into insulin-producing cells.
23	17303930	Cells treated with conophylline and betacellulin-delta4 continued to grow after differentiation.
24	17303930	Thus, cell number and insulin content were much greater compared to cells treated with activin A and betacellulin.
25	17303930	Furthermore, cells treated with conophylline and betacellulin-delta4 secreted insulin in response to glucose.
26	17303930	Likewise, conophylline and betacellulin-delta4 converted pancreatic ductal cells into insulin-producing cells.
27	17303930	Insulin content, cell number and glucose-evoked insulin secretion were significantly greater than those in cells treated with activin A and betacellulin.
28	17303930	Transplantation of pseudoislets prepared using ductal cells treated with conophylline and betacellulin-delta4 was able to reduce effectively the plasma glucose concentration in streptozotocin-treated nude mice.
29	17303930	Conophylline and betacellulin-delta4 are effective in inducing differentiation of beta cells from progenitors.
30	17303930	Conophylline and betacellulin-delta4: an effective combination of differentiation factors for pancreatic beta cells.
31	17303930	Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and betacellulin, respectively.
32	17303930	We examined the effect of conophylline and betacellulin-delta4 on beta cell differentiation.
33	17303930	In AR42J cells, conophylline and betacellulin-delta4 converted them into insulin-producing cells.
34	17303930	Cells treated with conophylline and betacellulin-delta4 continued to grow after differentiation.
35	17303930	Thus, cell number and insulin content were much greater compared to cells treated with activin A and betacellulin.
36	17303930	Furthermore, cells treated with conophylline and betacellulin-delta4 secreted insulin in response to glucose.
37	17303930	Likewise, conophylline and betacellulin-delta4 converted pancreatic ductal cells into insulin-producing cells.
38	17303930	Insulin content, cell number and glucose-evoked insulin secretion were significantly greater than those in cells treated with activin A and betacellulin.
39	17303930	Transplantation of pseudoislets prepared using ductal cells treated with conophylline and betacellulin-delta4 was able to reduce effectively the plasma glucose concentration in streptozotocin-treated nude mice.
40	17303930	Conophylline and betacellulin-delta4 are effective in inducing differentiation of beta cells from progenitors.
41	17303930	Conophylline and betacellulin-delta4: an effective combination of differentiation factors for pancreatic beta cells.
42	17303930	Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and betacellulin, respectively.
43	17303930	We examined the effect of conophylline and betacellulin-delta4 on beta cell differentiation.
44	17303930	In AR42J cells, conophylline and betacellulin-delta4 converted them into insulin-producing cells.
45	17303930	Cells treated with conophylline and betacellulin-delta4 continued to grow after differentiation.
46	17303930	Thus, cell number and insulin content were much greater compared to cells treated with activin A and betacellulin.
47	17303930	Furthermore, cells treated with conophylline and betacellulin-delta4 secreted insulin in response to glucose.
48	17303930	Likewise, conophylline and betacellulin-delta4 converted pancreatic ductal cells into insulin-producing cells.
49	17303930	Insulin content, cell number and glucose-evoked insulin secretion were significantly greater than those in cells treated with activin A and betacellulin.
50	17303930	Transplantation of pseudoislets prepared using ductal cells treated with conophylline and betacellulin-delta4 was able to reduce effectively the plasma glucose concentration in streptozotocin-treated nude mice.
51	17303930	Conophylline and betacellulin-delta4 are effective in inducing differentiation of beta cells from progenitors.
52	17303930	Conophylline and betacellulin-delta4: an effective combination of differentiation factors for pancreatic beta cells.
53	17303930	Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and betacellulin, respectively.
54	17303930	We examined the effect of conophylline and betacellulin-delta4 on beta cell differentiation.
55	17303930	In AR42J cells, conophylline and betacellulin-delta4 converted them into insulin-producing cells.
56	17303930	Cells treated with conophylline and betacellulin-delta4 continued to grow after differentiation.
57	17303930	Thus, cell number and insulin content were much greater compared to cells treated with activin A and betacellulin.
58	17303930	Furthermore, cells treated with conophylline and betacellulin-delta4 secreted insulin in response to glucose.
59	17303930	Likewise, conophylline and betacellulin-delta4 converted pancreatic ductal cells into insulin-producing cells.
60	17303930	Insulin content, cell number and glucose-evoked insulin secretion were significantly greater than those in cells treated with activin A and betacellulin.
61	17303930	Transplantation of pseudoislets prepared using ductal cells treated with conophylline and betacellulin-delta4 was able to reduce effectively the plasma glucose concentration in streptozotocin-treated nude mice.
62	17303930	Conophylline and betacellulin-delta4 are effective in inducing differentiation of beta cells from progenitors.
63	17303930	Conophylline and betacellulin-delta4: an effective combination of differentiation factors for pancreatic beta cells.
64	17303930	Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and betacellulin, respectively.
65	17303930	We examined the effect of conophylline and betacellulin-delta4 on beta cell differentiation.
66	17303930	In AR42J cells, conophylline and betacellulin-delta4 converted them into insulin-producing cells.
67	17303930	Cells treated with conophylline and betacellulin-delta4 continued to grow after differentiation.
68	17303930	Thus, cell number and insulin content were much greater compared to cells treated with activin A and betacellulin.
69	17303930	Furthermore, cells treated with conophylline and betacellulin-delta4 secreted insulin in response to glucose.
70	17303930	Likewise, conophylline and betacellulin-delta4 converted pancreatic ductal cells into insulin-producing cells.
71	17303930	Insulin content, cell number and glucose-evoked insulin secretion were significantly greater than those in cells treated with activin A and betacellulin.
72	17303930	Transplantation of pseudoislets prepared using ductal cells treated with conophylline and betacellulin-delta4 was able to reduce effectively the plasma glucose concentration in streptozotocin-treated nude mice.
73	17303930	Conophylline and betacellulin-delta4 are effective in inducing differentiation of beta cells from progenitors.
74	17303930	Conophylline and betacellulin-delta4: an effective combination of differentiation factors for pancreatic beta cells.
75	17303930	Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and betacellulin, respectively.
76	17303930	We examined the effect of conophylline and betacellulin-delta4 on beta cell differentiation.
77	17303930	In AR42J cells, conophylline and betacellulin-delta4 converted them into insulin-producing cells.
78	17303930	Cells treated with conophylline and betacellulin-delta4 continued to grow after differentiation.
79	17303930	Thus, cell number and insulin content were much greater compared to cells treated with activin A and betacellulin.
80	17303930	Furthermore, cells treated with conophylline and betacellulin-delta4 secreted insulin in response to glucose.
81	17303930	Likewise, conophylline and betacellulin-delta4 converted pancreatic ductal cells into insulin-producing cells.
82	17303930	Insulin content, cell number and glucose-evoked insulin secretion were significantly greater than those in cells treated with activin A and betacellulin.
83	17303930	Transplantation of pseudoislets prepared using ductal cells treated with conophylline and betacellulin-delta4 was able to reduce effectively the plasma glucose concentration in streptozotocin-treated nude mice.
84	17303930	Conophylline and betacellulin-delta4 are effective in inducing differentiation of beta cells from progenitors.
85	17303930	Conophylline and betacellulin-delta4: an effective combination of differentiation factors for pancreatic beta cells.
86	17303930	Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and betacellulin, respectively.
87	17303930	We examined the effect of conophylline and betacellulin-delta4 on beta cell differentiation.
88	17303930	In AR42J cells, conophylline and betacellulin-delta4 converted them into insulin-producing cells.
89	17303930	Cells treated with conophylline and betacellulin-delta4 continued to grow after differentiation.
90	17303930	Thus, cell number and insulin content were much greater compared to cells treated with activin A and betacellulin.
91	17303930	Furthermore, cells treated with conophylline and betacellulin-delta4 secreted insulin in response to glucose.
92	17303930	Likewise, conophylline and betacellulin-delta4 converted pancreatic ductal cells into insulin-producing cells.
93	17303930	Insulin content, cell number and glucose-evoked insulin secretion were significantly greater than those in cells treated with activin A and betacellulin.
94	17303930	Transplantation of pseudoislets prepared using ductal cells treated with conophylline and betacellulin-delta4 was able to reduce effectively the plasma glucose concentration in streptozotocin-treated nude mice.
95	17303930	Conophylline and betacellulin-delta4 are effective in inducing differentiation of beta cells from progenitors.
96	17303930	Conophylline and betacellulin-delta4: an effective combination of differentiation factors for pancreatic beta cells.
97	17303930	Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and betacellulin, respectively.
98	17303930	We examined the effect of conophylline and betacellulin-delta4 on beta cell differentiation.
99	17303930	In AR42J cells, conophylline and betacellulin-delta4 converted them into insulin-producing cells.
100	17303930	Cells treated with conophylline and betacellulin-delta4 continued to grow after differentiation.
101	17303930	Thus, cell number and insulin content were much greater compared to cells treated with activin A and betacellulin.
102	17303930	Furthermore, cells treated with conophylline and betacellulin-delta4 secreted insulin in response to glucose.
103	17303930	Likewise, conophylline and betacellulin-delta4 converted pancreatic ductal cells into insulin-producing cells.
104	17303930	Insulin content, cell number and glucose-evoked insulin secretion were significantly greater than those in cells treated with activin A and betacellulin.
105	17303930	Transplantation of pseudoislets prepared using ductal cells treated with conophylline and betacellulin-delta4 was able to reduce effectively the plasma glucose concentration in streptozotocin-treated nude mice.
106	17303930	Conophylline and betacellulin-delta4 are effective in inducing differentiation of beta cells from progenitors.
107	17303930	Conophylline and betacellulin-delta4: an effective combination of differentiation factors for pancreatic beta cells.
108	17303930	Conophylline and betacellulin-delta4 reproduce differentiation-inducing activity of activin A and betacellulin, respectively.
109	17303930	We examined the effect of conophylline and betacellulin-delta4 on beta cell differentiation.
110	17303930	In AR42J cells, conophylline and betacellulin-delta4 converted them into insulin-producing cells.
111	17303930	Cells treated with conophylline and betacellulin-delta4 continued to grow after differentiation.
112	17303930	Thus, cell number and insulin content were much greater compared to cells treated with activin A and betacellulin.
113	17303930	Furthermore, cells treated with conophylline and betacellulin-delta4 secreted insulin in response to glucose.
114	17303930	Likewise, conophylline and betacellulin-delta4 converted pancreatic ductal cells into insulin-producing cells.
115	17303930	Insulin content, cell number and glucose-evoked insulin secretion were significantly greater than those in cells treated with activin A and betacellulin.
116	17303930	Transplantation of pseudoislets prepared using ductal cells treated with conophylline and betacellulin-delta4 was able to reduce effectively the plasma glucose concentration in streptozotocin-treated nude mice.
117	17303930	Conophylline and betacellulin-delta4 are effective in inducing differentiation of beta cells from progenitors.
118	19474391	We have studied (P)RR expression in mouse brain, as well as the effect of transfection of Delta4-(P)RR on neuronal differentiation of rat neuroendocrine PC-12 cells induced by nerve growth factor (NGF).
119	19474391	In mouse neurons, the receptor is on the plasma membrane and in synaptic vesicles, and stimulation by renin provokes ERK1/2 phosphorylation.
120	19474391	In contrast, Delta4-(P)RR remained cytosolic and inhibited NGF-induced neuronal differentiation and ERK1/2 activation.
121	19474391	Cotransfection of PC-12 cells with (P)RR and Delta4-(P)RR cDNA resulted in altered localization of (P)RR and inhibited (P)RR redistribution to neurite projections upon NGF stimulation.
122	19474391	We have studied (P)RR expression in mouse brain, as well as the effect of transfection of Delta4-(P)RR on neuronal differentiation of rat neuroendocrine PC-12 cells induced by nerve growth factor (NGF).
123	19474391	In mouse neurons, the receptor is on the plasma membrane and in synaptic vesicles, and stimulation by renin provokes ERK1/2 phosphorylation.
124	19474391	In contrast, Delta4-(P)RR remained cytosolic and inhibited NGF-induced neuronal differentiation and ERK1/2 activation.
125	19474391	Cotransfection of PC-12 cells with (P)RR and Delta4-(P)RR cDNA resulted in altered localization of (P)RR and inhibited (P)RR redistribution to neurite projections upon NGF stimulation.
126	19474391	We have studied (P)RR expression in mouse brain, as well as the effect of transfection of Delta4-(P)RR on neuronal differentiation of rat neuroendocrine PC-12 cells induced by nerve growth factor (NGF).
127	19474391	In mouse neurons, the receptor is on the plasma membrane and in synaptic vesicles, and stimulation by renin provokes ERK1/2 phosphorylation.
128	19474391	In contrast, Delta4-(P)RR remained cytosolic and inhibited NGF-induced neuronal differentiation and ERK1/2 activation.
129	19474391	Cotransfection of PC-12 cells with (P)RR and Delta4-(P)RR cDNA resulted in altered localization of (P)RR and inhibited (P)RR redistribution to neurite projections upon NGF stimulation.
130	19550075	Administration of conophylline and betacellulin-delta4 increases the beta-cell mass in neonatal streptozotocin-treated rats.
131	19550075	The beta-cell mass and the insulin content of the pancreas were significantly increased in the CnP group and delta4 group.
132	19550075	CnP+BTCdelta4 significantly increased the number of PDX-1-positive ductal cells and the number of insulin/BrdU double-positive ductal cells.
133	19550075	Administration of conophylline and betacellulin-delta4 increases the beta-cell mass in neonatal streptozotocin-treated rats.
134	19550075	The beta-cell mass and the insulin content of the pancreas were significantly increased in the CnP group and delta4 group.
135	19550075	CnP+BTCdelta4 significantly increased the number of PDX-1-positive ductal cells and the number of insulin/BrdU double-positive ductal cells.
136	22547652	We found that Dll4 pharmacological blockade induces accumulation of tDCs and CD4(+)CD25(+)FoxP3(+) regulatory T cells (T(reg) cells) in the thymic cortex.
137	22547652	Anti-Dll4 treatment converts CD4(-)CD8(-)c-kit(+)CD44(+)CD25(-) (DN1) T cell progenitors to immature DCs that induce ex vivo differentiation of naive CD4(+) T cells into T(reg) cells.
138	22547652	Induction of these tolerogenic DN1-derived tDCs and the ensuing expansion of T(reg) cells are Fms-like tyrosine kinase 3 (Flt3) independent, occur in the context of transcriptional up-regulation of PU.1, Irf-4, Irf-8, and CSF-1, genes critical for DC differentiation, and are abrogated in thymectomized mice.
139	19483106	Peroxisome proliferator-activated receptor (PPAR)-gamma positively controls and PPARalpha negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARbeta/delta via mutual control of PPAR expression levels.
140	19483106	The present study was designed to compare the effects of combinations of synthetic agonists of PPARalpha [2-[4-[2-[4-cyclohexylbutyl (cyclohexylcarbamoyl)amino]ethyl]phenyl] sulfanyl-2-methylpropanoic acid (GW7647)], PPARbeta/delta [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid, (L-165041)], and PPARgamma (rosiglitazone, ciglitazone) on inflammatory gene regulation in rat primary astrocytes.
141	19483106	PPARalpha, PPARbeta/delta, and PPARgamma knockdown models served to delineate the contribution of each PPAR isotype.
142	19483106	However, the addition of L-165041 potentiated the effect of PPARgamma activation through PPARbeta/delta-dependent mechanism.
143	19483106	A PPARbeta/delta overexpression model confirmed that PPARbeta/delta expression level is the point at which PPARgamma and PPARalpha pathways converge in control of COX-2 gene expression.
144	19483106	Thus, we discovered that in primary astrocytes, PPARgamma has a positive influence and PPARalpha has a negative influence on PPARbeta/delta expression and activity.
145	19483106	A positive/negative-feedback loop is formed by PPARbeta/delta-dependent increase in PPARalpha expression level.