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Gene Information
Gene symbol: DNASE2
Gene name: deoxyribonuclease II, lysosomal
HGNC ID: 2960
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACACA | 1 hits |
| 2 | FASN | 1 hits |
| 3 | INS | 1 hits |
| 4 | SCD | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20032470 | SCD knockdown with small interfering RNA caused down-regulation of DNL and of expression of DNL-related genes, with reduced membrane fluidity (p < 0.02) and insulin sensitivity (p < 0.01), compared with scrambled small interfering RNA controls. |
| 2 | 23349482 | Endoplasmic reticulum (ER) stress is suggested to cause hepatic insulin resistance by increasing de novo lipogenesis (DNL) and directly interfering with insulin signaling through the activation of the c-Jun N-terminal kinase (JNK) and IκB kinase (IKK) pathway. |
| 3 | 23349482 | Of note, both the IRE1/XBP1 and PERK/eIF2α arms of unfolded protein response (UPR) signaling were activated. |
| 4 | 23349482 | While retaining the elevated DNL (indicated by the upregulation of SREBP1c, ACC, FAS, and SCD1 and [3H]H2O incorporation into lipids), FB treatment markedly increased fatty acid oxidation (indicated by induction of ACOX1, p-ACC, β-HAD activity, and [14C]palmitate oxidation) and eliminated the accumulation of diacylglycerols (DAGs), which is known to have an impact on insulin signaling. |
| 5 | 23349482 | These findings suggest that lipid accumulation (mainly DAGs), rather than the activation of JNK or IKK, is pivotal for ER stress to cause hepatic insulin resistance. |