Ignet

Gene Information

Gene symbol: DNMT3B

Gene name: DNA (cytosine-5-)-methyltransferase 3 beta

HGNC ID: 2979

Related Genes

#	Gene Symbol	Number of hits
1	APOB	1 hits
2	BECN1	1 hits
3	CDKN2A	1 hits
4	DNMT1	1 hits
5	DNMT3A	1 hits
6	FRAP1	1 hits
7	HBA1	1 hits
8	IGF1R	1 hits
9	ING1	1 hits
10	NCF4	1 hits
11	NOTCH1	1 hits
12	PPARG	1 hits
13	PPARGC1A	1 hits
14	SCD	1 hits
15	SIRT1	1 hits
16	TP53	1 hits
17	TRDMT1	1 hits
18	UCP2	1 hits
19	UCP3	1 hits
20	VEZF1	1 hits
21	ZMPSTE24	1 hits

Related Sentences

#	PMID	Sentence
1	1841815	HbA1 levels in the 2 CF groups were greater than that of controls subjects, but there was little difference between ICF and NCF groups.
2	1841815	Serum IRT concentration was significantly lower in the ICF and NCF groups compared to control subjects, and was lowest in the ICF group.
3	1841815	A strong correlation was observed in the ICF group between FEF25-75 and AUC for insulin, as well as HbA1 level and AUC for glucose.
4	1841815	HbA1 levels in the 2 CF groups were greater than that of controls subjects, but there was little difference between ICF and NCF groups.
5	1841815	Serum IRT concentration was significantly lower in the ICF and NCF groups compared to control subjects, and was lowest in the ICF group.
6	1841815	A strong correlation was observed in the ICF group between FEF25-75 and AUC for insulin, as well as HbA1 level and AUC for glucose.
7	18676812	Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b.
8	18676812	The chicken homolog, BGP1, has binding sites in the beta-globin locus, including the upstream insulator element.
9	18676812	Loss of methylation appears to arise from a substantial decrease in the abundance of the de novo DNA methyltransferase, Dnmt3b.
10	18676812	These results suggest that naturally occurring mutations in Vezf1/BGP1 might have widespread effects on DNA methylation patterns and therefore on epigenetic regulation of gene expression.
11	18676812	Vezf1 regulates genomic DNA methylation through its effects on expression of DNA methyltransferase Dnmt3b.
12	18676812	The chicken homolog, BGP1, has binding sites in the beta-globin locus, including the upstream insulator element.
13	18676812	Loss of methylation appears to arise from a substantial decrease in the abundance of the de novo DNA methyltransferase, Dnmt3b.
14	18676812	These results suggest that naturally occurring mutations in Vezf1/BGP1 might have widespread effects on DNA methylation patterns and therefore on epigenetic regulation of gene expression.
15	19680556	We re-sequenced all exons, intron-exon boundaries and selected conserved non-coding sequences of candidate genes involved in aging-related processes, including dietary restriction (PPARG, PPARGC1A, SIRT1, SIRT3, UCP2, UCP3), metabolism (IGF1R, APOB, SCD), autophagy (BECN1, FRAP1), stem cell activation (NOTCH1, DLL1), tumor suppression (TP53, CDKN2A, ING1), DNA methylation (TRDMT1, DNMT3A, DNMT3B) Progeria syndromes (LMNA, ZMPSTE24, KL) and stress response (CRYAB, HSPB2).
16	22308494	In Vezf1(-/-) mouse embryonic stem (mES) cells, our earlier data showed widespread changes in gene-expression profiles, including decreased expression of the full-length active isoform of Dnmt3b methyltransferase and concomitant genome-wide reduction in DNA methylation.
17	22308494	In WT mES cells, the elongating form of RNA pol II accumulates near Vezf1 binding sites within the dnmt3b gene and at several other Vezf1 sites, and this accumulation is significantly reduced at these sites in Vezf1(-/-) mES cells.
18	22308494	In Vezf1(-/-) mouse embryonic stem (mES) cells, our earlier data showed widespread changes in gene-expression profiles, including decreased expression of the full-length active isoform of Dnmt3b methyltransferase and concomitant genome-wide reduction in DNA methylation.
19	22308494	In WT mES cells, the elongating form of RNA pol II accumulates near Vezf1 binding sites within the dnmt3b gene and at several other Vezf1 sites, and this accumulation is significantly reduced at these sites in Vezf1(-/-) mES cells.
20	22842467	We tested the hypothesis that miR-133a regulates DNA methylation by inhibiting Dnmt-1 (maintenance) and Dnmt-3a and -3b (de novo) methyl transferases in diabetic hearts by using Ins2(+/-) Akita (diabetic) and C57BL/6J (WT), mice and HL1 cardiomyocytes.
21	22842467	The results revealed that miR-133a is inhibited but Dnmt-1 and -3b are induced in Akita suggesting that attenuation of miR-133a induces both maintenance (Dnmt-1) - and de novo - methylation (Dnmt-3b) in diabetes.
22	22842467	The HG treatment up regulates only Dnmt-1 and not Dnmt-3a and -3b suggesting that acute hyperglycemia triggers only maintenance methylation.