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Gene Information
Gene symbol: DOK4
Gene name: docking protein 4
HGNC ID: 19868
Synonyms: FLJ10488
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CRK | 1 hits |
| 2 | GRB2 | 1 hits |
| 3 | INSR | 1 hits |
| 4 | MAPK1 | 1 hits |
| 5 | NCK1 | 1 hits |
| 6 | PIK3CA | 1 hits |
| 7 | PIK3R1 | 1 hits |
| 8 | PTPN11 | 1 hits |
| 9 | RASA1 | 1 hits |
| 10 | SRC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12730241 | Because the other known PH-PTB proteins (insulin receptor substrates: IRS-1, IRS-2, IRS-3, and IRS-4, and the downstream of kinases: DOK-1, DOK-2, and DOK-3) are substrates of insulin and insulin-like growth factor (IGF)-1 receptors, we asked whether these new proteins, termed IRS5/DOK4 and IRS6/DOK5, might also have roles in insulin and IGF-1 signaling. |
| 2 | 12730241 | Both proteins are tyrosine-phosphorylated in response to insulin and IGF-1 in transfected cells, although the kinetics differ. |
| 3 | 12730241 | Insulin receptor-phosphorylated IRS5/DOK4 associates with RasGAP, Crk, Src, and Fyn, but not phosphatidylinositol 3-kinase p85, Grb2, SHP-2, Nck, or phospholipase Cgamma Src homology 2 domains, and activates MAPK in cells. |
| 4 | 12730241 | IRS5/DOK4 and IRS6/DOK5 represent two new signaling proteins with potential roles in insulin and IGF-1 action. |