Ignet

Gene Information

Gene symbol: DYNC1H1

Gene name: dynein, cytoplasmic 1, heavy chain 1

HGNC ID: 2961

Synonyms: Dnchc1, HL-3, p22, DHC1

Related Genes

#	Gene Symbol	Number of hits
1	AAVS1	1 hits
2	ACTB	1 hits
3	AVP	1 hits
4	BRCA1	1 hits
5	CD33	1 hits
6	CD44	1 hits
7	CDKN1C	1 hits
8	CLEC11A	1 hits
9	CSF1	1 hits
10	DDIT3	1 hits
11	DNAH5	1 hits
12	DNAH6	1 hits
13	FOS	1 hits
14	GPR180	1 hits
15	HIST1H2BO	1 hits
16	HIST2H2BE	1 hits
17	HSPG2	1 hits
18	IGF1	1 hits
19	IGFALS	1 hits
20	IGFBP2	1 hits
21	IL2	1 hits
22	INS	1 hits
23	ITLN1	1 hits
24	MDK	1 hits
25	MFN1	1 hits
26	MLLT3	1 hits
27	NOX5	1 hits
28	PML	1 hits
29	SLC9A3R2	1 hits
30	SMARCA1	1 hits
31	SMN1	1 hits
32	TP63	1 hits

Related Sentences

#	PMID	Sentence
1	6590897	[A case of acute promyelocytic leukemia associated with diabetes insipidus and chromosomal abnormality, t(8;17) (p22;q21)].
2	9032395	The Rep proteins of adeno-associated virus type 2 (AAV) are known to bind to Rep recognition sequences (RRSs) in the AAV inverted terminal repeats (ITRs), the AAV p5 promoter, and the preferred AAV integration site in human chromosome 19, called AAVS1.
3	9032395	We used the 16-mer core sequences of the RRSs in the AAV ITRs and AAVS1 separately as query sequences and identified 18 new RRSs in or flanking the genes coding for the following: tyrosine kinase activator protein 1 (TKA-1); colony stimulating factor-1; insulin-like growth factor binding protein 2 (IGFBP-2); histone H2B.1; basement membrane heparan sulfate proteoglycan, also known as perlecan; the AF-9 gene product, which is involved in the chromosomal translocation t (9:11)(p22:q23); the betaB subunit of the hormone known as inhibin; interleukin-2 enhancer binding factor; an endoplasmic reticulum-Golgi intermediate compartment resident protein called p63; a global transcription activator (hSNF2L); the beta-actin repair domain; a retinoic acid-inducible factor, also known as midkine; a breast tumor autoantigen; a growth-arrest- and DNA-damage-inducible protein called gadd45; the cyclin-dependent kinase inhibitor called KIP2, which inhibits several G1 cyclin-cyclin-dependent kinase complexes; and the hereditary breast and ovarian cancer gene (BRCA1).
4	12526711	A set of four bifunctional ligand precursors were synthesized: (+/-)-5-[4-[(5-hydroxy-4-oxo-4H-pyran-2-ylmethyl)amino]benzyl]thiazolidine-2,4-dione (HL(1)), (+/-)-5-[4-[(5-hydroxy-1-methyl-4-oxo-1,4-dihydro-pyridin-2-ylmethyl)amino]benzyl]thiazolidine-2,4-dione (HL(2)), 5-[4-(5-hydroxy-4-oxo-4H-pyran-2-ylmethoxy)benzylidene]thiazolidine-2,4-dione (HL(3)), and (+/-)-5-[4-(5-hydroxy-4-oxo-4H-pyran-2-ylmethoxy)benzyl]thiazolidine-2,4-dione (HL(4)), each containing a metal chelating portion as well as a thiazolidinedione moiety.
5	12526711	Both the ligand precursors HL(1) and HL(3) showed enhanced activity compared with that of rosiglitazone.
6	12526711	A set of four bifunctional ligand precursors were synthesized: (+/-)-5-[4-[(5-hydroxy-4-oxo-4H-pyran-2-ylmethyl)amino]benzyl]thiazolidine-2,4-dione (HL(1)), (+/-)-5-[4-[(5-hydroxy-1-methyl-4-oxo-1,4-dihydro-pyridin-2-ylmethyl)amino]benzyl]thiazolidine-2,4-dione (HL(2)), 5-[4-(5-hydroxy-4-oxo-4H-pyran-2-ylmethoxy)benzylidene]thiazolidine-2,4-dione (HL(3)), and (+/-)-5-[4-(5-hydroxy-4-oxo-4H-pyran-2-ylmethoxy)benzyl]thiazolidine-2,4-dione (HL(4)), each containing a metal chelating portion as well as a thiazolidinedione moiety.
7	12526711	Both the ligand precursors HL(1) and HL(3) showed enhanced activity compared with that of rosiglitazone.
8	20200810	NADPH oxidase is a major resource of reactive oxygen species (ROS) in the testes and is likely related to an activated endothelin-1 (ET-1) system.
9	20200810	Blood glucose, testosterone, follicle stimulating hormone (FSH) , luteinizing hormone (LH) and expressions of NADPH oxidase subunits and the ET system were measured.
10	20200810	Additionally, over-expressions of NADPH oxidase p22, p47, p67 subunits and the ET pathway were significant in the diabetic testis relative to normal and were completely abolished by FDP-Sr.
11	23742762	Mutations in the DYNC1H1 gene encoding for dynein heavy chain cause two closely related human motor neuropathies, dominant spinal muscular atrophy with lower extremity predominance (SMA-LED) and axonal Charcot-Marie-Tooth (CMT) disease, and lead to sensory neuropathy and striatal atrophy in mutant mice.
12	23742762	Here, we show that mouse fibroblasts bearing heterozygous or homozygous point mutation in Dync1h1, similar to human mutations, show profoundly abnormal mitochondrial morphology associated with the loss of mitofusin 1.
13	23742762	Mutations in the DYNC1H1 gene encoding for dynein heavy chain cause two closely related human motor neuropathies, dominant spinal muscular atrophy with lower extremity predominance (SMA-LED) and axonal Charcot-Marie-Tooth (CMT) disease, and lead to sensory neuropathy and striatal atrophy in mutant mice.
14	23742762	Here, we show that mouse fibroblasts bearing heterozygous or homozygous point mutation in Dync1h1, similar to human mutations, show profoundly abnormal mitochondrial morphology associated with the loss of mitofusin 1.