Ignet

Gene Information

Gene symbol: ECE2

Gene name: endothelin converting enzyme 2

HGNC ID: 13275

Synonyms: KIAA0604, MGC2408

Related Genes

#	Gene Symbol	Number of hits
1	ACE	1 hits
2	ECE1	1 hits
3	MMP2	1 hits
4	PLAT	1 hits
5	PLAU	1 hits
6	PLG	1 hits

Related Sentences

#	PMID	Sentence
1	16009335	Endothelial NO bioactivity in the aorta was reduced in diabetic NOD mice while vascular expression of ECE-1 and ECE-2 mRNA was increased compared with controls (all p<0.05).
2	16009335	ET(A) receptor blockade also restored abnormal endothelial NO bioactivity and reduced ECE-1 and ECE-2 gene expression in NOD mice to levels comparable with healthy controls (p<0.05).
3	16009335	Endothelial NO bioactivity in the aorta was reduced in diabetic NOD mice while vascular expression of ECE-1 and ECE-2 mRNA was increased compared with controls (all p<0.05).
4	16009335	ET(A) receptor blockade also restored abnormal endothelial NO bioactivity and reduced ECE-1 and ECE-2 gene expression in NOD mice to levels comparable with healthy controls (p<0.05).
5	16741043	Blood samples were analyzed for glucose levels, and renal gene expression of ECE-1, ECE-2, and prepro-ET-1 was determined using real-time polymerase chain reaction.
6	16741043	ECE-1, ECE-2, and prepro-ET-1 mRNA was detected in the kidneys of NOD and control mice.
7	16741043	Despite normal renal histology, expression of ECE-1 and prepro-ET-1 was reduced in NOD mice by approximately 50% compared with controls (P < 0.01); ECE-2 was markedly decreased by almost 90% compared with controls (P < 0.001).
8	16741043	Hyperglycemia at an early stage of autoimmune diabetes is associated with transcriptional downregulation of ECE-1, ECE-2, and prepro-ET-1 in the kidney.
9	16741043	Blood samples were analyzed for glucose levels, and renal gene expression of ECE-1, ECE-2, and prepro-ET-1 was determined using real-time polymerase chain reaction.
10	16741043	ECE-1, ECE-2, and prepro-ET-1 mRNA was detected in the kidneys of NOD and control mice.
11	16741043	Despite normal renal histology, expression of ECE-1 and prepro-ET-1 was reduced in NOD mice by approximately 50% compared with controls (P < 0.01); ECE-2 was markedly decreased by almost 90% compared with controls (P < 0.001).
12	16741043	Hyperglycemia at an early stage of autoimmune diabetes is associated with transcriptional downregulation of ECE-1, ECE-2, and prepro-ET-1 in the kidney.
13	16741043	Blood samples were analyzed for glucose levels, and renal gene expression of ECE-1, ECE-2, and prepro-ET-1 was determined using real-time polymerase chain reaction.
14	16741043	ECE-1, ECE-2, and prepro-ET-1 mRNA was detected in the kidneys of NOD and control mice.
15	16741043	Despite normal renal histology, expression of ECE-1 and prepro-ET-1 was reduced in NOD mice by approximately 50% compared with controls (P < 0.01); ECE-2 was markedly decreased by almost 90% compared with controls (P < 0.001).
16	16741043	Hyperglycemia at an early stage of autoimmune diabetes is associated with transcriptional downregulation of ECE-1, ECE-2, and prepro-ET-1 in the kidney.
17	16741043	Blood samples were analyzed for glucose levels, and renal gene expression of ECE-1, ECE-2, and prepro-ET-1 was determined using real-time polymerase chain reaction.
18	16741043	ECE-1, ECE-2, and prepro-ET-1 mRNA was detected in the kidneys of NOD and control mice.
19	16741043	Despite normal renal histology, expression of ECE-1 and prepro-ET-1 was reduced in NOD mice by approximately 50% compared with controls (P < 0.01); ECE-2 was markedly decreased by almost 90% compared with controls (P < 0.001).
20	16741043	Hyperglycemia at an early stage of autoimmune diabetes is associated with transcriptional downregulation of ECE-1, ECE-2, and prepro-ET-1 in the kidney.
21	18363935	Neprilysin and insulin-degrading enzyme (IDE), which have been most extensively studied, are expressed both neuronally and within the vasculature.
22	18363935	Other enzymes shown capable of degrading Abetain vitro or in animal studies include plasmin; endothelin-converting enzymes ECE-1 and -2; matrix metalloproteinases MMP-2, -3 and -9; and angiotensin-converting enzyme (ACE).
23	18363935	The levels of plasmin and plasminogen activators (uPA and tPA) and ECE-2 are reported to be reduced in AD.
24	18363935	Reductions in neprilysin, IDE and plasmin in AD have been associated with possession of APOEepsilon4.
25	18363935	The level and activity of ACE are increased, the level being directly related to Abeta plaque load.
26	18363935	Neprilysin and insulin-degrading enzyme (IDE), which have been most extensively studied, are expressed both neuronally and within the vasculature.
27	18363935	Other enzymes shown capable of degrading Abetain vitro or in animal studies include plasmin; endothelin-converting enzymes ECE-1 and -2; matrix metalloproteinases MMP-2, -3 and -9; and angiotensin-converting enzyme (ACE).
28	18363935	The levels of plasmin and plasminogen activators (uPA and tPA) and ECE-2 are reported to be reduced in AD.
29	18363935	Reductions in neprilysin, IDE and plasmin in AD have been associated with possession of APOEepsilon4.
30	18363935	The level and activity of ACE are increased, the level being directly related to Abeta plaque load.