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Gene Information
Gene symbol: ELSPBP1
Gene name: epididymal sperm binding protein 1
HGNC ID: 14417
Synonyms: HE12, E12, EDDM12
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EP300 | 1 hits |
| 2 | INS | 1 hits |
| 3 | PDX1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15001545 | Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300. |
| 2 | 15001545 | The homeodomain transcription factor, pancreas duodenum homeobox (PDX)-1, is essential for pancreas development, insulin production, and glucose homeostasis. |
| 3 | 15001545 | PDX-1 interacts with multiple transcription factors and coregulators, including the coactivator p300, to activate the transcription of the insulin gene and other target genes within pancreatic beta-cells. |
| 4 | 15001545 | In characterizing the protein-protein interactions of PDX-1 and p300, we identified mutations in PDX-1 that disrupt its function and are associated with increased or decreased interactions with p300. |
| 5 | 15001545 | Several mutant PDX-1 proteins that are associated with heritable forms of diabetes in humans, in particular the mutant P63fsdelC, exhibited increased binding to a carboxy-terminal segment of p300 in the setting of decreased DNA-binding activities, suggesting that sequestration of p300 by mutant PDX-1 proteins may be an additional mechanism by which insulin gene expression is reduced in heterozygous carriers of pdx-1(ipf-1) mutations. |
| 6 | 15001545 | The introduction of the point mutations S66A/Y68A in the highly conserved amino-terminal PDX-1 transactivation domain reduced the ability of PDX-1 to interact with p300, substantially diminished the transcriptional activation of PDX-1, and reduced the synergistic activation of glucose-responsive insulin promoter enhancer sequences by PDX-1, E12, and E47. |
| 7 | 15001545 | We propose that interactions of PDX-1 with p300 are required for the transcriptional activation of PDX-1 target genes. |
| 8 | 15001545 | Impairment of interactions between PDX-1 and p300 in pancreatic beta-cells may limit insulin production and lead to the development of diabetes. |
| 9 | 19275670 | The roles of the PDZ-containing proteins bridge-1 and PDZD2 in the regulation of insulin production and pancreatic beta-cell mass. |
| 10 | 19275670 | In a screen for interactors that regulate transcription factor function in pancreatic beta cells, we isolated two PDZ-containing proteins Bridge-1 (PSMD9) and PDZD2, which contain one and six PDZ domains, respectively. |
| 11 | 19275670 | Bridge-1 interacts with both E12 and PDX-1 to stimulate insulin promoter activity. |
| 12 | 19275670 | Interestingly, PDZD2 is proteolytically processed by caspase-3 to generate a carboxy-terminal secreted protein (sPDZD2) containing two PDZ domains. |
| 13 | 19275670 | We propose that the PDZ domain proteins Bridge-1 and PDZD2 likely transduce signals that regulate insulin production, proliferation, and survival of pancreatic beta cells. |