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Gene Information
Gene symbol: ERAP1
Gene name: endoplasmic reticulum aminopeptidase 1
HGNC ID: 18173
Synonyms: ARTS-1, A-LAP, PILS-AP, KIAA0525, ERAAP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | COL1A1 | 1 hits |
| 2 | ERAP2 | 1 hits |
| 3 | HLA-A | 1 hits |
| 4 | IL10 | 1 hits |
| 5 | INS | 1 hits |
| 6 | LAP3 | 1 hits |
| 7 | PIP4K2C | 1 hits |
| 8 | STAT3 | 1 hits |
| 9 | STAT4 | 1 hits |
| 10 | TNFAIP3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8883027 | Urinary leucine aminopeptidase is a more sensitive indicator of early renal damage in non-insulin-dependent diabetics than microalbuminuria. |
| 2 | 8883027 | We measured urinary activity of leucine aminopeptidase (EC 3.4.11.2) and creatinine concentrations (Cr, in mmol) in samples of second morning urine from 25 healthy subjects and 59 non-insulin-dependent diabetic (NIDD) subjects. |
| 3 | 8883027 | We have also found a LAP/Cr ratio abnormality of 91% in group B. |
| 4 | 19110536 | In up to 8010 cases and 9733 controls we found some evidence for an association with T1D in the regions containing genes: 2q32/STAT4, 17q21/STAT3, 5p15/ERAP1 (ARTS1), 6q23/TNFAIP3 and 12q13/KIF5A/PIP4K2C with allelic P-values ranging from 3.70 x 10(-3) to 3.20 x 10(-5). |
| 5 | 20720210 | Nasal anti-CD3 induced a LAP(+) regulatory T cell that secreted high levels of IL-10 and suppressed collagen-specific T cell proliferation and anti-collagen Ab production. |
| 6 | 20720210 | Suppression of arthritis by mucosal anti-CD3 was associated with less joint damage, a decrease of TNF-alpha and IFN-gamma mRNA expression in joints, and a reduction in anti-collagen Abs. |
| 7 | 22575366 | These peptide/MHC class I complexes are generated and assembled through MHC class I antigen processing and presentation machinery. |
| 8 | 22575366 | In the endoplasmic reticulum (ER), aminopeptidases ERAP1 and ERAP2 display distinct trimming activity before antigenic peptides are loaded onto MHC class I molecules. |
| 9 | 22575366 | Recent GWAS showed the importance of ERAP1 and ERAP2 in several autoimmune diseases, including ankylosing spondylitis, insulin-dependent diabetes mellitus, psoriasis, multiple sclerosis, Crohn's disease. |
| 10 | 22575366 | In this review, we first provide a general overview of ERAP1 and ERAP2 genes, their biological functions and their relevancy in autoimmunity. |
| 11 | 22575366 | These peptide/MHC class I complexes are generated and assembled through MHC class I antigen processing and presentation machinery. |
| 12 | 22575366 | In the endoplasmic reticulum (ER), aminopeptidases ERAP1 and ERAP2 display distinct trimming activity before antigenic peptides are loaded onto MHC class I molecules. |
| 13 | 22575366 | Recent GWAS showed the importance of ERAP1 and ERAP2 in several autoimmune diseases, including ankylosing spondylitis, insulin-dependent diabetes mellitus, psoriasis, multiple sclerosis, Crohn's disease. |
| 14 | 22575366 | In this review, we first provide a general overview of ERAP1 and ERAP2 genes, their biological functions and their relevancy in autoimmunity. |
| 15 | 22575366 | These peptide/MHC class I complexes are generated and assembled through MHC class I antigen processing and presentation machinery. |
| 16 | 22575366 | In the endoplasmic reticulum (ER), aminopeptidases ERAP1 and ERAP2 display distinct trimming activity before antigenic peptides are loaded onto MHC class I molecules. |
| 17 | 22575366 | Recent GWAS showed the importance of ERAP1 and ERAP2 in several autoimmune diseases, including ankylosing spondylitis, insulin-dependent diabetes mellitus, psoriasis, multiple sclerosis, Crohn's disease. |
| 18 | 22575366 | In this review, we first provide a general overview of ERAP1 and ERAP2 genes, their biological functions and their relevancy in autoimmunity. |