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Gene Information
Gene symbol: ERBB4
Gene name: v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
HGNC ID: 3432
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD9 | 1 hits |
| 2 | EGF | 1 hits |
| 3 | EGFR | 1 hits |
| 4 | HBEGF | 1 hits |
| 5 | IRS1 | 1 hits |
| 6 | NTRK1 | 1 hits |
| 7 | SHC1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7499194 | PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. |
| 2 | 7499194 | By serial truncation, we show that a 174-residue region of Shc p52 (33-206) has full PTB activity. |
| 3 | 7499194 | Phosphopeptide assays developed to compare PTB domain specificities show that the Shc PTB domain binds with highest affinity to psi XN beta 1 beta 2 pY motifs derived from middle T (mT), TrkA, ErbB4, or epidermal growth factor receptors (psi = hydrophobic, beta = beta-turn forming); the IRS-1 PTB domain does not bind with this motif. |
| 4 | 7499194 | In contrast, both the Shc and IRS-1 PTB domains bind psi psi psi XXN beta 1 beta 2pY sequences derived from insulin and interleukin 4 receptors, although specificities vary in detail. |
| 5 | 7499194 | Shc and IRS-1 are phosphorylated by distinct but overlapping sets of receptor-linked tyrosine kinases. |
| 6 | 19608732 | Previously, we found that overexpression of the growth factor heparin-binding epidermal growth factor-like growth factor (HB-EGF) in pancreatic islets led to intraislet fibrosis. |
| 7 | 19608732 | HB-EGF binds to and activates two receptors, epidermal growth factor receptor (EGFR) and ErbB4, as well as heparin moieties and CD9/DRAP27. |
| 8 | 19608732 | To understand the mechanism underlying the induction of fibrogenesis by HB-EGF, we utilized a hypomorphic allele of Egfr, the Waved-2 allele, to demonstrate that EGFR signaling regulates fibrogenesis in vivo. |
| 9 | 19608732 | Using an in vitro cell migration assay, we show that HB-EGF regulates both chemoattraction and stimulation of proliferation of PSCs via EGFR activation. |