Ignet

Gene Information

Gene symbol: F2RL3

Gene name: coagulation factor II (thrombin) receptor-like 3

HGNC ID: 3540

Synonyms: PAR4

Related Genes

#	Gene Symbol	Number of hits
1	COL18A1	1 hits
2	MARK2	1 hits
3	NR1I2	1 hits
4	PAWR	1 hits
5	VEGFA	1 hits

Related Sentences

#	PMID	Sentence
1	15615851	Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets.
2	15615851	Among these is the release of factors that regulate the process of angiogenesis, such as endostatin and VEGF, which, respectively, inhibit and promote angiogenesis.
3	15615851	PAR1 and PAR4 are expressed on the surface of human platelets and can be activated by thrombin.
4	15615851	In the present study, we have attempted to determine the roles of PAR1 and PAR4 in regulating release of endostatin and VEGF from human platelets.
5	15615851	Aggregation and endostatin release could be elicited by a specific PAR4 agonist (AYPGKF-NH(2)).
6	15615851	The PAR4 agonist concentration dependently suppressed VEGF release.
7	15615851	A selective PAR1 agonist (TFLLR-NH(2)) induced platelet aggregation and VEGF release but suppressed endostatin release.
8	15615851	Thrombin did not affect endostatin or VEGF release.
9	15615851	However, in the presence of a selective PAR1 antagonist (SCH79797), thrombin stimulated endostatin release and suppressed VEGF release.
10	15615851	Conversely, in the presence of a selective PAR4 antagonist (transcinnamoyl-YPGKF-NH(2)), thrombin stimulated VEGF release.
11	15615851	In vivo, treatment of rats with established gastric ulcers with a PAR1 antagonist each day for 1 wk resulted in a significant retardation of healing.
12	15615851	We conclude that PAR1 and PAR4 counter-regulate the release of endostatin and VEGF from platelets.
13	15615851	Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets.
14	15615851	Among these is the release of factors that regulate the process of angiogenesis, such as endostatin and VEGF, which, respectively, inhibit and promote angiogenesis.
15	15615851	PAR1 and PAR4 are expressed on the surface of human platelets and can be activated by thrombin.
16	15615851	In the present study, we have attempted to determine the roles of PAR1 and PAR4 in regulating release of endostatin and VEGF from human platelets.
17	15615851	Aggregation and endostatin release could be elicited by a specific PAR4 agonist (AYPGKF-NH(2)).
18	15615851	The PAR4 agonist concentration dependently suppressed VEGF release.
19	15615851	A selective PAR1 agonist (TFLLR-NH(2)) induced platelet aggregation and VEGF release but suppressed endostatin release.
20	15615851	Thrombin did not affect endostatin or VEGF release.
21	15615851	However, in the presence of a selective PAR1 antagonist (SCH79797), thrombin stimulated endostatin release and suppressed VEGF release.
22	15615851	Conversely, in the presence of a selective PAR4 antagonist (transcinnamoyl-YPGKF-NH(2)), thrombin stimulated VEGF release.
23	15615851	In vivo, treatment of rats with established gastric ulcers with a PAR1 antagonist each day for 1 wk resulted in a significant retardation of healing.
24	15615851	We conclude that PAR1 and PAR4 counter-regulate the release of endostatin and VEGF from platelets.
25	15615851	Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets.
26	15615851	Among these is the release of factors that regulate the process of angiogenesis, such as endostatin and VEGF, which, respectively, inhibit and promote angiogenesis.
27	15615851	PAR1 and PAR4 are expressed on the surface of human platelets and can be activated by thrombin.
28	15615851	In the present study, we have attempted to determine the roles of PAR1 and PAR4 in regulating release of endostatin and VEGF from human platelets.
29	15615851	Aggregation and endostatin release could be elicited by a specific PAR4 agonist (AYPGKF-NH(2)).
30	15615851	The PAR4 agonist concentration dependently suppressed VEGF release.
31	15615851	A selective PAR1 agonist (TFLLR-NH(2)) induced platelet aggregation and VEGF release but suppressed endostatin release.
32	15615851	Thrombin did not affect endostatin or VEGF release.
33	15615851	However, in the presence of a selective PAR1 antagonist (SCH79797), thrombin stimulated endostatin release and suppressed VEGF release.
34	15615851	Conversely, in the presence of a selective PAR4 antagonist (transcinnamoyl-YPGKF-NH(2)), thrombin stimulated VEGF release.
35	15615851	In vivo, treatment of rats with established gastric ulcers with a PAR1 antagonist each day for 1 wk resulted in a significant retardation of healing.
36	15615851	We conclude that PAR1 and PAR4 counter-regulate the release of endostatin and VEGF from platelets.