Ignet

Gene Information

Gene symbol: FBXL20

Gene name: F-box and leucine-rich repeat protein 20

HGNC ID: 24679

Synonyms: MGC15482, Fbl2, Fbl20

Related Genes

#	Gene Symbol	Number of hits
1	ALB	1 hits
2	EDN1	1 hits
3	NAGLU	1 hits
4	NPPA	1 hits
5	RENBP	1 hits
6	SCGB1A1	1 hits
7	TGFB1	1 hits
8	VEGFA	1 hits

Related Sentences

#	PMID	Sentence
1	8544416	Urinary excretion of five low molecular weight proteins (LMWP) [beta 2-microglobulin (beta 2m), cystatin C (cyst C), Clara cell protein (CC16), retinol-binding protein (RBP) and alpha 1-microglobulin (alpha 1m)], albumin and N-acetyl-beta-D-glucosaminidase (NAG) were quantified in 16 patients who followed a weight reduction program which included Chinese herbs, which have been incriminated in the genesis of Chinese herbs nephropathy (CHN).
2	8544416	In four of them (CHN1a) only beta 2m, RBP and CC16 were increased while total proteinuria and SCr were normal.
3	8544416	In the other four (CHN1b and c) albumin, cyst C, alpha 1m and NAG were also elevated, while total proteinuria and SCr were moderately raised.
4	8544416	Five patients (CHN2) with a S beta 2m > or = 5 mg/liter had a markedly increased excretion of all LMWP, albumin and NAG (CHN1 vs.
5	8544416	The urinary LMWP/albumin concentration ratio was strikingly higher in CHN patients than in patients with glomerular albuminuria (CHN1 vs.
6	8544416	Its most sensitive and reliable marker is a raised urinary level of CC16 or RBP.
7	8544416	Urinary excretion of five low molecular weight proteins (LMWP) [beta 2-microglobulin (beta 2m), cystatin C (cyst C), Clara cell protein (CC16), retinol-binding protein (RBP) and alpha 1-microglobulin (alpha 1m)], albumin and N-acetyl-beta-D-glucosaminidase (NAG) were quantified in 16 patients who followed a weight reduction program which included Chinese herbs, which have been incriminated in the genesis of Chinese herbs nephropathy (CHN).
8	8544416	In four of them (CHN1a) only beta 2m, RBP and CC16 were increased while total proteinuria and SCr were normal.
9	8544416	In the other four (CHN1b and c) albumin, cyst C, alpha 1m and NAG were also elevated, while total proteinuria and SCr were moderately raised.
10	8544416	Five patients (CHN2) with a S beta 2m > or = 5 mg/liter had a markedly increased excretion of all LMWP, albumin and NAG (CHN1 vs.
11	8544416	The urinary LMWP/albumin concentration ratio was strikingly higher in CHN patients than in patients with glomerular albuminuria (CHN1 vs.
12	8544416	Its most sensitive and reliable marker is a raised urinary level of CC16 or RBP.
13	15934303	The serum creatinine (Scr), protein kinase C (PKC), creatinine clearance (Ccr), transforming growth factor-beta, (TGF-beta1), type IV collagen were compared among the groups after 24 weeks.
14	15934303	The results showed that after 24 weeks, Scr, PKC, TGF-beta1 in group D were significantly lower than in group C, meanwhile, renal pathologic changes in group D were improved.
15	23548123	The urinary albumin excretion rate (UAER), and endothelin 1 (ET-1), and atrial natriuretic peptide (ANP) levels were determined with a radioimmunoassay, and vascular endothelial growth factor (VEGF) was detected using an enzyme-linked immunosorbent assay.
16	23548123	Secondary endpoints were change from baseline to post-treatment in FBG, TC, TG, UAER, SCr, Ccr, VI-C, ANP, ET-1, and VEGF.
17	23548123	ZSTL was significantly more effective at improving the primary (i.e., HbA1c) and secondary (i.e., FBG, TC, TG, UAER, SCr, ANP, ET-1, and VEGF) outcomes than benazepril (p < 0.05).
18	23548123	These findings suggest that ZSTL is superior to benazepril at improving the metabolic and renal functioning in patients with early-stage DN, in part, by modifying ANP, ET-1, and VEGF.
19	23548123	The urinary albumin excretion rate (UAER), and endothelin 1 (ET-1), and atrial natriuretic peptide (ANP) levels were determined with a radioimmunoassay, and vascular endothelial growth factor (VEGF) was detected using an enzyme-linked immunosorbent assay.
20	23548123	Secondary endpoints were change from baseline to post-treatment in FBG, TC, TG, UAER, SCr, Ccr, VI-C, ANP, ET-1, and VEGF.
21	23548123	ZSTL was significantly more effective at improving the primary (i.e., HbA1c) and secondary (i.e., FBG, TC, TG, UAER, SCr, ANP, ET-1, and VEGF) outcomes than benazepril (p < 0.05).
22	23548123	These findings suggest that ZSTL is superior to benazepril at improving the metabolic and renal functioning in patients with early-stage DN, in part, by modifying ANP, ET-1, and VEGF.