Ignet

Gene Information

Gene symbol: FGF7

Gene name: fibroblast growth factor 7

HGNC ID: 3685

Synonyms: KGF

Related Genes

#	Gene Symbol	Number of hits
1	EGF	1 hits
2	EGFR	1 hits
3	FGF1	1 hits
4	FGF10	1 hits
5	FGF2	1 hits
6	FGF4	1 hits
7	FGF5	1 hits
8	FGFR1	1 hits
9	FGFR2	1 hits
10	FOS	1 hits
11	HGF	1 hits
12	IGF1	1 hits
13	IGF1R	1 hits
14	IGF2	1 hits
15	IL1B	1 hits
16	INS	1 hits
17	JUN	1 hits
18	KRT19	1 hits
19	KRT8	1 hits
20	MAPK1	1 hits
21	NUDT6	1 hits
22	PDGFB	1 hits
23	PDX1	1 hits
24	RPS27A	1 hits
25	TF	1 hits
26	TGFB1	1 hits
27	TNF	1 hits
28	VEGFA	1 hits

Related Sentences

#	PMID	Sentence
1	7759509	We found a large induction of VEGF expression upon treatment of quiescent cells with serum, epidermal growth factor, transforming growth factor-beta 1, keratinocyte growth factor, or the proinflammatory cytokine tumor necrosis factor alpha, respectively.
2	8013761	The formation of islet-like cell clusters (ICCs) during a 6-day culture was stimulated two- to threefold by hepatocyte growth factor/scatter factor (HGF/SF) basic fibroblast growth factor (FGF)-2, and to a lesser extent by keratinocyte growth factor (FGF-7) and insulin-like growth factor-II (IGF-II).
3	8013761	The ICCs formed during HGF/SF stimulation consisted mainly of epithelial cells, whereas FGF-2-induced ICCs were predominantly nonepithelial.
4	8013761	Furthermore, although both FGF-2 and HGF/SF increased the total insulin content of the cultures, only HGF/SF increased the insulin content per DNA.
5	8013761	Quantitatively, HGF/SF stimulated a 2.3-fold increase in the proportion of insulin-positive cells and a 3-fold higher number of replicating beta-cells.
6	8013761	Blocking of the IGF-I receptor inhibited ICC formation but did not affect their insulin content.
7	8013761	Immunoneutralizing TGF-beta resulted in increased cell growth and insulin content, indicating the presence of an endogenous inhibitory TGF-beta activity in the model system.
8	10748122	A novel type I fibroblast growth factor receptor activates mitogenic signaling in the absence of detectable tyrosine phosphorylation of FRS2.
9	10748122	A novel variant of the fibroblast growth factor receptor type 1 (FGFR-1) was identified in human placental RNA.
10	10748122	Transfected L6 clones expressed respective proteins and bound (125)I-labeled FGF-2 with K(d) values of 99 pm (FGFR-1) and 26 pm (FGFR-1L).
11	10748122	FGF-1 and FGF-2 competed efficiently with (125)I-FGF-2 for binding to FGFR-1 and FGFR-1L, whereas FGF-4 was less efficient.
12	10748122	FGF-1, FGF-2, and FGF-4 enhanced mitogen-activated protein kinase (MAPK) activity, increased steady-state c-fos mRNA levels, and stimulated proliferation through either receptor, whereas KGF was without effect.
13	10748122	FGFR-1 expressing clones exhibited ligand-induced tyrosine phosphorylation of fibroblast growth factor receptor substrate 2 (FRS2), a 90-kDa adaptor protein that links FGFR-1 activation to the MAPK cascade.
14	10748122	These findings indicate that FGFR-1L binds FGF-1 and FGF-2 with high affinity and is capable of mitogenic signaling, but may activate MAPK to occur via non-classical signaling intermediates.
15	11130726	Here we show that the FGF receptors (FGFRs) 1 and 2, together with the ligands FGF1, FGF2, FGF4, FGF5, FGF7 and FGF10, are expressed in adult mouse beta-cells, indicating that FGF signalling may have a role in differentiated beta-cells.
16	11130726	We also show that Ipf1/Pdx1 is required for the expression of FGFR1 signalling components in beta-cells, indicating that Ipf1/Pdx1 acts upstream of FGFR1 signalling in beta-cells to maintain proper glucose sensing, insulin processing and glucose homeostasis.
17	12007725	In the present study we examined the potential morphogenic activities of the growth factors FGF1, FGF2 and FGF7, and cellular processes underlying morphogenesis, in pancreatic cells from streptozotocin diabetic newborn rats.
18	12007725	The most prominent stimulatory effect was found after application of FGF2 and 7 at a dose of 100 ng/l in endocrine and exocrine cells of diabetic rats.
19	12007725	It is concluded that FGF2 and 7 might act as putative key-signalling molecules in the differentiation of pancreatic cells.
20	12007725	In the present study we examined the potential morphogenic activities of the growth factors FGF1, FGF2 and FGF7, and cellular processes underlying morphogenesis, in pancreatic cells from streptozotocin diabetic newborn rats.
21	12007725	The most prominent stimulatory effect was found after application of FGF2 and 7 at a dose of 100 ng/l in endocrine and exocrine cells of diabetic rats.
22	12007725	It is concluded that FGF2 and 7 might act as putative key-signalling molecules in the differentiation of pancreatic cells.
23	12007725	In the present study we examined the potential morphogenic activities of the growth factors FGF1, FGF2 and FGF7, and cellular processes underlying morphogenesis, in pancreatic cells from streptozotocin diabetic newborn rats.
24	12007725	The most prominent stimulatory effect was found after application of FGF2 and 7 at a dose of 100 ng/l in endocrine and exocrine cells of diabetic rats.
25	12007725	It is concluded that FGF2 and 7 might act as putative key-signalling molecules in the differentiation of pancreatic cells.
26	12815830	In contrary, local application of keratinocyte growth factor (KGF) as well as insulin-like growth factor-I (IGF-I) have been shown to accelerate and improve anastomotic healing and mechanical stability in an animal model.
27	17109637	Role of FGF1, FGF2 and FGF7 in the development of the pancreas from control and streptozotocin-treated hamsters.
28	17109637	In this study we have examined the structure characteristics, functional and proliferative activity of control and diabetic hamster pancreatic ductal, exocrine and beta cells, following treatment with FGFs 1, 2 and 7 in vitro.
29	17109637	We established that FGF2 at a concentration of 10 ng/l was responsible for the most prominent effect on ductal cells and beta cells in the diabetic groups.
30	17109637	Taken together these data strongly suggest that FGF1 and FGF2 induce proliferation of pancreatic epithelial cells during the early post-natal period whereas FGF7 is not strictly specific for pancreatic cell proliferation.
31	17109637	Role of FGF1, FGF2 and FGF7 in the development of the pancreas from control and streptozotocin-treated hamsters.
32	17109637	In this study we have examined the structure characteristics, functional and proliferative activity of control and diabetic hamster pancreatic ductal, exocrine and beta cells, following treatment with FGFs 1, 2 and 7 in vitro.
33	17109637	We established that FGF2 at a concentration of 10 ng/l was responsible for the most prominent effect on ductal cells and beta cells in the diabetic groups.
34	17109637	Taken together these data strongly suggest that FGF1 and FGF2 induce proliferation of pancreatic epithelial cells during the early post-natal period whereas FGF7 is not strictly specific for pancreatic cell proliferation.
35	17109637	Role of FGF1, FGF2 and FGF7 in the development of the pancreas from control and streptozotocin-treated hamsters.
36	17109637	In this study we have examined the structure characteristics, functional and proliferative activity of control and diabetic hamster pancreatic ductal, exocrine and beta cells, following treatment with FGFs 1, 2 and 7 in vitro.
37	17109637	We established that FGF2 at a concentration of 10 ng/l was responsible for the most prominent effect on ductal cells and beta cells in the diabetic groups.
38	17109637	Taken together these data strongly suggest that FGF1 and FGF2 induce proliferation of pancreatic epithelial cells during the early post-natal period whereas FGF7 is not strictly specific for pancreatic cell proliferation.
39	17951544	KGF exerts strong mitogenic effect on the pancreatic duct cells, thus expanding the population of precursor cells that subsequently differentiate into insulin-producing beta-cells.
40	20659357	Among them, keratinocyte growth factor and platelet-derived growth factor were highly expressed in the EPCs and were present at substantial levels in the EPC-injected dermal tissue.
41	21031338	It could be shown that the applied anabolic combination significantly influenced the expression of the steroid receptor ERα, the keratinization factor CK8, the proinflammatory interleukins IL-1α and IL-1β, the growth factors FGF7, EGF, EGFR, IGF-1R, TGFα and LTF, the oncogen c-jun and other factors like actinβ and ubiquitin 3.
42	21855631	In this study, we describe the roles of growth factors bFGF, BMP4 and Activin A in early hESC fate determination.
43	21855631	The entire differentiation process is carried out in serum-free chemically-defined media (CDM) and results in reliable and robust induction of pancreatic endoderm cells, marked by PDX1, and cell clusters co-expressing markers characteristic of beta cells, including PDX1 and insulin/C-peptide.
44	21855631	Varying the combinations of growth factors, we found that treatment of hESCs with bFGF, Activin A and BMP4 (FAB) together for 3-4days resulted in strong induction of primitive-streak and definitive endoderm-associated genes, including MIXL1, GSC, SOX17 and FOXA2.
45	21855631	Early proliferative foregut endoderm and pancreatic lineage cells marked by PDX1, FOXA2 and SOX9 expression are specified in EBs made from FAB-treated hESCs, but not from Activin A alone treated cells.
46	21855631	Further differentiation occurs after EBs are embedded in Matrigel and cultured in serum-free media containing insulin, transferrin, selenium, FGF7, nicotinamide, islet neogenesis associated peptide (INGAP) and exendin-4, a long acting GLP-1 agonist. 21-28days after embedding, PDX1 gene expression levels are comparable to those of human islets used for transplantation, and many PDX1(+) clusters are formed.
47	21855631	Almost all cells in PDX1(+) clusters co-express FOXA2, HNF1ß, HNF6 and SOX9 proteins, and many cells also express CPA1, NKX6.1 and PTF1a.
48	22442738	The CD90 cell surface marker was used to remove the vimentin+ cells from islet-depleted human pancreas cell cultures by magnetic-activated cell sorting.
49	22442738	A full-factorial experimental design was then applied to test the mitogenic effects of bFGF, EGF, HGF, KGF and VEGF.
50	22442738	This screening assay confirmed the expected mitogenic effects of bFGF, EGF, HGF and KGF on CK19+ cells and additionally revealed interactions between these factors and VEGF.
51	22442738	A serum-free medium containing bFGF, EGF, HGF and KGF led to CK19+ cell expansion comparable to the addition of 10% serum.
52	22442738	The CD90 cell surface marker was used to remove the vimentin+ cells from islet-depleted human pancreas cell cultures by magnetic-activated cell sorting.
53	22442738	A full-factorial experimental design was then applied to test the mitogenic effects of bFGF, EGF, HGF, KGF and VEGF.
54	22442738	This screening assay confirmed the expected mitogenic effects of bFGF, EGF, HGF and KGF on CK19+ cells and additionally revealed interactions between these factors and VEGF.
55	22442738	A serum-free medium containing bFGF, EGF, HGF and KGF led to CK19+ cell expansion comparable to the addition of 10% serum.
56	22442738	The CD90 cell surface marker was used to remove the vimentin+ cells from islet-depleted human pancreas cell cultures by magnetic-activated cell sorting.
57	22442738	A full-factorial experimental design was then applied to test the mitogenic effects of bFGF, EGF, HGF, KGF and VEGF.
58	22442738	This screening assay confirmed the expected mitogenic effects of bFGF, EGF, HGF and KGF on CK19+ cells and additionally revealed interactions between these factors and VEGF.
59	22442738	A serum-free medium containing bFGF, EGF, HGF and KGF led to CK19+ cell expansion comparable to the addition of 10% serum.