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Gene Information
Gene symbol: FLG
Gene name: filaggrin
HGNC ID: 3748
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CTNNB1 | 1 hits |
| 2 | EBM | 1 hits |
| 3 | IVL | 1 hits |
| 4 | JUP | 1 hits |
| 5 | LOR | 1 hits |
| 6 | SPG7 | 1 hits |
| 7 | TLR2 | 1 hits |
| 8 | TLR4 | 1 hits |
| 9 | TLR5 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12813461 | Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. |
| 2 | 12813461 | The Wnt/beta-catenin signaling pathway is critical for normal mammalian development, the specification of epidermal cells and neoplastic transformation of intestinal epithelium. |
| 3 | 12813461 | However, precise molecular information regarding cell-specific responses to beta-catenin signaling has been limited. |
| 4 | 12813461 | This question was addressed using a mouse model in which exon 3 of the beta-catenin gene was deleted in several cell types with loxP-mediated recombination utilizing a Cre transgene under control of the mouse mammary tumor virus-long terminal repeat (MMTV-LTR). |
| 5 | 12813461 | The stabilization of beta-catenin in prostate epithelium resulted in hyperplasias and extensive transdifferentiation into epidermal-like structures, which expressed keratins 1 and 6, filaggrin, loricrin and involucrin. |
| 6 | 12813461 | The cell-specific loss of NKCC1 protein and reduced nuclear Stat5a is further suggestive of a loss of prostate epithelial characteristics. |
| 7 | 12813461 | Since beta-catenin was activated in several cell types and impinged upon the viability of these mice, it was not possible to evaluate the cumulative effect over more than 3 months. |
| 8 | 12813461 | To assess long-term consequences of beta-catenin activation, mutant and control prostate tissues were transplanted into the mammary fat pads of wild-type males. |
| 9 | 12813461 | Notably, squamous metaplasias, intra-acinous hyperplasia and possible neoplastic transformation were observed after a total of 18 weeks of beta-catenin stimulation. |
| 10 | 12813461 | This suggests that the transdifferentiation into squamous metaplasias is an early response of endoderm-derived cells to beta-catenin, and that the development of intra-acinous hyperplasias or neoplastic foci is a later event. |
| 11 | 16480422 | In a murine model of epidermal hyperplasia reproducing some of the abnormalities of several common skin disorders, we previously demonstrated the antiproliferative and pro-differentiating effects of peroxisome proliferator-activated receptor (PPAR)alpha, PPARbeta/delta, and liver X receptor activators. |
| 12 | 16480422 | Unlike other subgroups of PPAR activators, thiazolidinediones (TZDs), a family of PPARgamma ligands, did not inhibit keratinocyte proliferation in normal murine skin. |
| 13 | 16480422 | We observed an increased expression of involucrin and filaggrin following ciglitazone treatment, suggesting a pro-differentiating action of TZDs in this model. |
| 14 | 18565177 | Dystrophic epidermolysis bullosa pruriginosa is not associated with frequent FLG gene mutations. |
| 15 | 22367599 | Toll-like receptor (TLR) ligands (TLR2: peptidoglycan, PGN; TLR4: lipopolysaccharide, LPS; TLR5: flagellin, FLG) were used to stimulate alveolar macrophages (AMs), and TNF-α production was measured. |
| 16 | 22367599 | Under hyperglycemic conditions and PGN or FLG stimulation, TNF-α production from AMs was significantly reduced in group B compared with group A. |
| 17 | 22367599 | Toll-like receptor (TLR) ligands (TLR2: peptidoglycan, PGN; TLR4: lipopolysaccharide, LPS; TLR5: flagellin, FLG) were used to stimulate alveolar macrophages (AMs), and TNF-α production was measured. |
| 18 | 22367599 | Under hyperglycemic conditions and PGN or FLG stimulation, TNF-α production from AMs was significantly reduced in group B compared with group A. |