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Gene Information
Gene symbol: FLT3
Gene name: fms-related tyrosine kinase 3
HGNC ID: 3765
Synonyms: STK1, FLK2, CD135
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABL1 | 1 hits |
| 2 | BCR | 1 hits |
| 3 | CD34 | 1 hits |
| 4 | CSF1 | 1 hits |
| 5 | CSF1R | 1 hits |
| 6 | IGHD6-13 | 1 hits |
| 7 | IL1B | 1 hits |
| 8 | IL3 | 1 hits |
| 9 | IL6 | 1 hits |
| 10 | IRF4 | 1 hits |
| 11 | IRF8 | 1 hits |
| 12 | KIT | 1 hits |
| 13 | KITLG | 1 hits |
| 14 | LCK | 1 hits |
| 15 | MAPK1 | 1 hits |
| 16 | PDGFRB | 1 hits |
| 17 | SPI1 | 1 hits |
| 18 | THPO | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12028051 | Platelet-derived growth factor promotes ex vivo expansion of CD34+ cells from human cord blood and enhances long-term culture-initiating cells, non-obese diabetic/severe combined immunodeficient repopulating cells and formation of adherent cells. |
| 2 | 12028051 | Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells. |
| 3 | 12028051 | In this study, we investigated the effects and mechanism of PDGF on the ex vivo expansion of cord blood CD34+ cells. |
| 4 | 12028051 | Our data demonstrated that among various cytokine combinations of thrombopoietin (TPO), interleukin 1 beta (IL-1beta), IL-3, IL-6 and Flt-3 ligand (Flt-3L), TPO + IL-6 + Flt-3L was most efficient in promoting the expansion of CD34+ cells, CD34+CD38- cells, mixed-lineage colony-forming units (CFU-GEMM) and long-term culture-initiating cells (LTC-IC) by 21.7 +/- 5.00-, 103 +/- 27.9-, 10.7 +/- 7.94- and 6.52 +/- 1.51-fold, respectively, after 12-14 d of culture. |
| 5 | 12028051 | More significantly, PDGF enhanced the engraftment of human CD45+ cells and their myeloid subsets (CD33+, CD14+ cells) in non-obese diabetic (NOD)/severe-combined immunodeficient (SCID) mice. |
| 6 | 12028051 | The expression of PDGF receptor (PDGFR)-beta was not detectable in fresh CD34+ cells but was upregulated after culture for 3 d. |
| 7 | 12028051 | PDGF also enhanced the development of adherent cells/clusters that expressed the endothelial markers VE-cadherin and CD31. |
| 8 | 12028051 | The mechanism could be mediated by PDGFR-beta on committed CD34+ progenitor cells and/or secondary to the stimulation of autologous, stromal feeder cells. |
| 9 | 21544097 | Single 24 h transduction of human CD34+ cells with human immunodeficiency virus type 1 (HIV1)-based lentiviral vectors in media containing stem cell factor (SCF), FMS-like tyrosine kinase 3 (FLT3) ligand, thrombopoietin (each 100 ng ml⁻¹) and 10% fetal bovine serum was compared with various cytokine conditions during ex vivo culture and assayed using humanized xenograft mice for 6 months after transplantation. |
| 10 | 21544097 | In summary, 24 h prestimulation followed by single 24-h lentiviral transduction in serum-free media with SCF, FLT3 ligand and thrombopoietin yields high transduction efficiency to engrafting human CD34+ cells, and is applicable in human clinical gene therapy trials. |
| 11 | 21544097 | Single 24 h transduction of human CD34+ cells with human immunodeficiency virus type 1 (HIV1)-based lentiviral vectors in media containing stem cell factor (SCF), FMS-like tyrosine kinase 3 (FLT3) ligand, thrombopoietin (each 100 ng ml⁻¹) and 10% fetal bovine serum was compared with various cytokine conditions during ex vivo culture and assayed using humanized xenograft mice for 6 months after transplantation. |
| 12 | 21544097 | In summary, 24 h prestimulation followed by single 24-h lentiviral transduction in serum-free media with SCF, FLT3 ligand and thrombopoietin yields high transduction efficiency to engrafting human CD34+ cells, and is applicable in human clinical gene therapy trials. |
| 13 | 22547652 | We found that Dll4 pharmacological blockade induces accumulation of tDCs and CD4(+)CD25(+)FoxP3(+) regulatory T cells (T(reg) cells) in the thymic cortex. |
| 14 | 22547652 | Anti-Dll4 treatment converts CD4(-)CD8(-)c-kit(+)CD44(+)CD25(-) (DN1) T cell progenitors to immature DCs that induce ex vivo differentiation of naive CD4(+) T cells into T(reg) cells. |
| 15 | 22547652 | Induction of these tolerogenic DN1-derived tDCs and the ensuing expansion of T(reg) cells are Fms-like tyrosine kinase 3 (Flt3) independent, occur in the context of transcriptional up-regulation of PU.1, Irf-4, Irf-8, and CSF-1, genes critical for DC differentiation, and are abrogated in thymectomized mice. |
| 16 | 23947692 | Imatinib mesylate is a selective protein tyrosine kinase inhibitor, which can inhibit BCR/Abl, PDGF-R, c-KIT, c-fms, TCR/Abl, Lck, FLT-3 and MAPKs activities on various cell types. |
| 17 | 23947692 | On immune system, imatinib has antiproliferative activity and immunomodulatory effects in lymphocytes, macrophages, mast cells and dendritic cells with abrogating multiple signal transduction pathways involved in pathogenesis of autoimmune diseases e.g. inhibiting IFN-γ, TNF-α, IL-1β and IL-17 pro-inflammatory cytokines and MMPs secretion. |