Ignet

Gene Information

Gene symbol: FMO1

Gene name: flavin containing monooxygenase 1

HGNC ID: 3769

Related Genes

#	Gene Symbol	Number of hits
1	CYP2E1	1 hits
2	CYP3A	1 hits
3	INS	1 hits

Related Sentences

#	PMID	Sentence
1	10900221	The relative roles of CYP2E1 and FMO1 in the mechanism of TA-associated liver injury were investigated.
2	10900221	Pretreatment with the CYP2E1 inducer, isoniazid (INH, 250 mg/kg, i.p.) before TA (300 mg/kg, i.p.) administration significantly increased TA-associated liver injury as assessed by plasma alanine aminotransferase (ALT).
3	10900221	In the STZ-induced diabetic rat, diabetes-induced CYP2E1 appears to be responsible for the potentiated liver injury; Even though hepatic FMO1 is induced in the diabetic rat, it is unlikely to mediate the potentiated TA hepatotoxicity.
4	10900221	The relative roles of CYP2E1 and FMO1 in the mechanism of TA-associated liver injury were investigated.
5	10900221	Pretreatment with the CYP2E1 inducer, isoniazid (INH, 250 mg/kg, i.p.) before TA (300 mg/kg, i.p.) administration significantly increased TA-associated liver injury as assessed by plasma alanine aminotransferase (ALT).
6	10900221	In the STZ-induced diabetic rat, diabetes-induced CYP2E1 appears to be responsible for the potentiated liver injury; Even though hepatic FMO1 is induced in the diabetic rat, it is unlikely to mediate the potentiated TA hepatotoxicity.
7	16488120	Flavin-containing monooxygenase and cytochrome P450 activities in experimental diabetes.
8	16488120	Microsomal monooxygenases - cytochrome P450 (CYP, EC 1.14.14.1) and flavin-containing monooxygenase (FMO, EC 1.14.13.8) - have profound roles in drug metabolism.
9	16488120	While the induction of some metabolic enzymes such as hepatic FMO and intestinal CYP1A, CYP2B is recognized in experimental diabetes, the effect of insulin treatment on FMO and intestinal CYP3A in diabetic animals has not been reported before.
10	16488120	Hepatic FMO1 activity increased in diabetic rats, but it was restored to control value on insulin treatment.
11	16488120	Insulin itself had no effect on FMO1 activity in non-diabetic animals.
12	16488120	A remarkable increase of total CYP content was accompanied by a reduced CYP3A specific enzyme activity in the small intestine of diabetic animals.
13	16488120	Both, hepatic FMO1 and intestinal CYP3A activity correlated with average blood glucose concentration in untreated diabetic rats.
14	16488120	These results indicate that insulin is involved in the regulation of hepatic FMO1 and intestinal CYP3A in rats.
15	16488120	The marked reduction of intestinal CYP3A capacity suggests that diabetes exerts a substantial effect on the activity of most determining intestinal CYP enzyme.
16	16488120	Flavin-containing monooxygenase and cytochrome P450 activities in experimental diabetes.
17	16488120	Microsomal monooxygenases - cytochrome P450 (CYP, EC 1.14.14.1) and flavin-containing monooxygenase (FMO, EC 1.14.13.8) - have profound roles in drug metabolism.
18	16488120	While the induction of some metabolic enzymes such as hepatic FMO and intestinal CYP1A, CYP2B is recognized in experimental diabetes, the effect of insulin treatment on FMO and intestinal CYP3A in diabetic animals has not been reported before.
19	16488120	Hepatic FMO1 activity increased in diabetic rats, but it was restored to control value on insulin treatment.
20	16488120	Insulin itself had no effect on FMO1 activity in non-diabetic animals.
21	16488120	A remarkable increase of total CYP content was accompanied by a reduced CYP3A specific enzyme activity in the small intestine of diabetic animals.
22	16488120	Both, hepatic FMO1 and intestinal CYP3A activity correlated with average blood glucose concentration in untreated diabetic rats.
23	16488120	These results indicate that insulin is involved in the regulation of hepatic FMO1 and intestinal CYP3A in rats.
24	16488120	The marked reduction of intestinal CYP3A capacity suggests that diabetes exerts a substantial effect on the activity of most determining intestinal CYP enzyme.
25	16488120	Flavin-containing monooxygenase and cytochrome P450 activities in experimental diabetes.
26	16488120	Microsomal monooxygenases - cytochrome P450 (CYP, EC 1.14.14.1) and flavin-containing monooxygenase (FMO, EC 1.14.13.8) - have profound roles in drug metabolism.
27	16488120	While the induction of some metabolic enzymes such as hepatic FMO and intestinal CYP1A, CYP2B is recognized in experimental diabetes, the effect of insulin treatment on FMO and intestinal CYP3A in diabetic animals has not been reported before.
28	16488120	Hepatic FMO1 activity increased in diabetic rats, but it was restored to control value on insulin treatment.
29	16488120	Insulin itself had no effect on FMO1 activity in non-diabetic animals.
30	16488120	A remarkable increase of total CYP content was accompanied by a reduced CYP3A specific enzyme activity in the small intestine of diabetic animals.
31	16488120	Both, hepatic FMO1 and intestinal CYP3A activity correlated with average blood glucose concentration in untreated diabetic rats.
32	16488120	These results indicate that insulin is involved in the regulation of hepatic FMO1 and intestinal CYP3A in rats.
33	16488120	The marked reduction of intestinal CYP3A capacity suggests that diabetes exerts a substantial effect on the activity of most determining intestinal CYP enzyme.
34	16488120	Flavin-containing monooxygenase and cytochrome P450 activities in experimental diabetes.
35	16488120	Microsomal monooxygenases - cytochrome P450 (CYP, EC 1.14.14.1) and flavin-containing monooxygenase (FMO, EC 1.14.13.8) - have profound roles in drug metabolism.
36	16488120	While the induction of some metabolic enzymes such as hepatic FMO and intestinal CYP1A, CYP2B is recognized in experimental diabetes, the effect of insulin treatment on FMO and intestinal CYP3A in diabetic animals has not been reported before.
37	16488120	Hepatic FMO1 activity increased in diabetic rats, but it was restored to control value on insulin treatment.
38	16488120	Insulin itself had no effect on FMO1 activity in non-diabetic animals.
39	16488120	A remarkable increase of total CYP content was accompanied by a reduced CYP3A specific enzyme activity in the small intestine of diabetic animals.
40	16488120	Both, hepatic FMO1 and intestinal CYP3A activity correlated with average blood glucose concentration in untreated diabetic rats.
41	16488120	These results indicate that insulin is involved in the regulation of hepatic FMO1 and intestinal CYP3A in rats.
42	16488120	The marked reduction of intestinal CYP3A capacity suggests that diabetes exerts a substantial effect on the activity of most determining intestinal CYP enzyme.