Ignet

Gene Information

Gene symbol: FOXP2

Gene name: forkhead box P2

HGNC ID: 13875

Synonyms: CAGH44

Related Genes

#	Gene Symbol	Number of hits
1	CD4	1 hits
2	CTLA4	1 hits
3	FOXA1	1 hits
4	FOXA2	1 hits
5	FOXA3	1 hits
6	FOXB1	1 hits
7	FOXC1	1 hits
8	FOXC2	1 hits
9	FOXD1	1 hits
10	FOXD2	1 hits
11	FOXD3	1 hits
12	FOXD4	1 hits
13	FOXD4L1	1 hits
14	FOXD4L3	1 hits
15	FOXE1	1 hits
16	FOXE3	1 hits
17	FOXF1	1 hits
18	FOXF2	1 hits
19	FOXG1	1 hits
20	FOXH1	1 hits
21	FOXI1	1 hits
22	FOXJ1	1 hits
23	FOXJ2	1 hits
24	FOXJ3	1 hits
25	FOXK1	1 hits
26	FOXK2	1 hits
27	FOXL1	1 hits
28	FOXL2	1 hits
29	FOXM1	1 hits
30	FOXN1	1 hits
31	FOXN2	1 hits
32	FOXN3	1 hits
33	FOXN4	1 hits
34	FOXO1	1 hits
35	FOXO3	1 hits
36	FOXO4	1 hits
37	FOXO6	1 hits
38	FOXP1	1 hits
39	FOXP3	1 hits
40	FOXP4	1 hits
41	FOXQ1	1 hits
42	FOXR1	1 hits
43	FOXR2	1 hits
44	IL2RA	1 hits
45	INS	1 hits
46	PDX1	1 hits
47	TNF	1 hits
48	TNFRSF18	1 hits

Related Sentences

#	PMID	Sentence
1	12145169	Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo.
2	12145169	Prior in vitro analysis has suggested that the forkhead/winged helix transcription factor Foxa2 (formerly HNF-3beta) is a major upstream regulator of Pdx1, a homeobox gene essential for pancreatic development.
3	12145169	To analyze the Foxa2/Pdx1 regulatory cascade during pancreatic beta-cell differentiation, we used conditional gene ablation of Foxa2 in mice.
4	12145169	We demonstrated that the deletion of Foxa2 in beta-cell-specific knockout mice results in downregulation of Pdx1 mRNA and subsequent reduction of PDX-1 protein levels in islets.
5	12145169	These data represent the first in vivo demonstration that Foxa2 acts upstream of Pdx1 in the differentiated beta-cell.
6	12540636	FOXC2, a forkhead/winged helix transcription factor, represents a promising candidate gene for type 2 diabetes since transgenic mice that specifically overexpress this gene in adipocytes are lean and insulin sensitive.
7	14597769	Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells.
8	14597769	CD4+CD25+ regulatory T (TR) cells have been described in both humans and mice.
9	14597769	Recently, the forkhead/winged helix transcription factor, FoxP3, has been shown to be important for the function of TR cells in mice.
10	14597769	In this study, human TR cells were examined and, in results similar to those of studies done in mice, expression of FoxP3 was found exclusively in CD4+CD25+ T cells and correlated with the suppressive activity of these cells.
11	14597769	In contrast to the mouse studies, activation of human CD4+CD25- T cells led to expression of FoxP3.
12	14597769	Expression of FoxP3 in activated human CD4+CD25+ cells also correlated with suppression of proliferation by these cells in freshly isolated CD4+CD25- T cells from the same donor.
13	14597769	Thus, in humans, during activation of CD4+CD25- T cells in an immune response, two populations of cells may arise, effector CD4+CD25+ and regulatory CD4+CD25+ T cells, with expression of FoxP3 correlated with regulatory activity.
14	15220219	Mutations of the forkhead/winged helix transcription factor FOXP3 gene on chromosome Xp11.23 cause a rare recessive monogenic disorder called IPEX (immune dysregulation, polyendocrinopathy, including type 1 diabetes, enteropathy, and X-linked syndrome).
15	15220219	FOXP3 is necessary for the differentiation of a key immune suppressive subset of T-cells, the CD4+CD25+ regulatory T-cells.
16	15492844	Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2, FOXE3, FOXF1, FOXF2, FOXG1 (FOXG1B), FOXH1, FOXI1, FOXJ1, FOXJ2, FOXJ3, FOXK1, FOXK2, FOXL1, FOXL2, FOXM1, FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1), FOXN6 (FOXR2), FOXO1 (FOXO1A), FOXO2 (FOXO6), FOXO3 (FOXO3A), FOXO4 (MLLT7), FOXP1, FOXP2, FOXP3, FOXP4, and FOXQ1.
17	15492844	FOXH1 and FOXO1 mRNAs are expressed in human embryonic stem (ES) cells.
18	15492844	FOXC1, FOXC2, FOXE1, FOXE3, FOXL2, FOXN1, FOXP2 and FOXP3 genes are mutated in human congenital disorders.
19	15492844	FOXM1 gene is up-regulated in pancreatic cancer and basal cell carcinoma due to the transcriptional regulation by Sonic Hedgehog (SHH) pathway.
20	15492844	FOXO1 gene is fused to PAX3 or PAX7 genes in rhabdomyosarcoma.
21	15492844	FOXO3 and FOXO4 genes are fused to MLL gene in hematological malignancies.
22	15492844	Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2, FOXE3, FOXF1, FOXF2, FOXG1 (FOXG1B), FOXH1, FOXI1, FOXJ1, FOXJ2, FOXJ3, FOXK1, FOXK2, FOXL1, FOXL2, FOXM1, FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1), FOXN6 (FOXR2), FOXO1 (FOXO1A), FOXO2 (FOXO6), FOXO3 (FOXO3A), FOXO4 (MLLT7), FOXP1, FOXP2, FOXP3, FOXP4, and FOXQ1.
23	15492844	FOXH1 and FOXO1 mRNAs are expressed in human embryonic stem (ES) cells.
24	15492844	FOXC1, FOXC2, FOXE1, FOXE3, FOXL2, FOXN1, FOXP2 and FOXP3 genes are mutated in human congenital disorders.
25	15492844	FOXM1 gene is up-regulated in pancreatic cancer and basal cell carcinoma due to the transcriptional regulation by Sonic Hedgehog (SHH) pathway.
26	15492844	FOXO1 gene is fused to PAX3 or PAX7 genes in rhabdomyosarcoma.
27	15492844	FOXO3 and FOXO4 genes are fused to MLL gene in hematological malignancies.
28	16585566	We show that effectors generated from murine islet-specific CD4 cells by TCR stimulation with IL-2 and TGF-beta1 have potent suppressive activity.
29	16585566	However, the adaptive population does acquire the X-linked forkhead/winged helix transcription factor, FoxP3, which is associated with regulatory T cell function and maintains expression in vivo.
30	16585566	In vivo, they eliminate Th1 cells in lymphoid tissues, where Fas/FasL interactions potentially play a role because Th1 cells persist when this pathway is blocked.
31	18465023	Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in prevention of autoimmune diabetes in non-obese diabetic mice treated with alpha-galactosylceramide.
32	18465023	CD1d-restricted natural killer T (NKT) cells and CD4+CD25+ regulatory T (Treg) cells are two thymus-derived subsets of regulatory T cells that play an important role in the maintenance of self-tolerance.
33	18465023	Yet the functional changes of the two subsets of regulatory T cells in the development of diabetes in non-obese diabetic (NOD) mice remain unclear, and how NKT cells and CD4+CD25+ Treg cells cooperate functionally in the regulation of autoimmune diabetes is also uncertain.
34	18465023	We provide evidence that in NOD mice, an animal model of human type 1 diabetes, the functions of both NKT cells and CD4+CD25+ Treg cells decrease in an age-dependent manner.
35	18465023	We show that treatment with alpha-galactosylceramide increases the size of the CD4+CD25+ Treg cell compartment in NOD mice, and augments the expression of forkhead/winged helix transcription factor and the potency of CD4+CD25+ Treg cells to inhibit proliferation of CD4+CD25- T cells.
36	18465023	Our data indicate that NKT cells and CD4+CD25+ Treg cells might cooperate in the prevention of autoimmune diabetes in NOD mice treated with alpha-galactosylceramide.
37	18465023	Induced cooperation of NKT cells and CD4+CD25+ Treg cells could serve as a strategy to treat human autoimmune disease, such as type 1 diabetes.
38	19120317	Multiple studies have shown that thymus-derived naturally occurring Tregs constitutively express the forkhead/winged helix transcription factor FoxP3 in addition to high levels of CD25, the negative co-stimulatory molecule CTLA-4, and the glucocorticoid-induced TNF receptor-related protein GITR.
39	19120317	At variance, adaptive or induced Tregs acquire these phenotypic markers as they differentiate in the periphery, following adequate stimulation in the appropriate environment, together with their capacity to produce immunomodulatory cytokines (mainly, IL-4, IL-10 and TGF-beta) and to display regulatory capacities.
40	19120317	Moreover, data are presented that simultaneous blockade of CTLA4 and TGF-beta further impairs immunoregulatory circuits that control disease progression.