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Gene Information

Gene symbol: GABARAPL1

Gene name: GABA(A) receptor-associated protein like 1

HGNC ID: 4068

Synonyms: gec1, APG8L, ATG8L, ATG8B

Related Genes

#	Gene Symbol	Number of hits
1	FBXO32	1 hits
2	INS	1 hits
3	MAP1LC3A	1 hits
4	TRIM63	1 hits

Related Sentences

#	PMID	Sentence
1	23757118	Insulin suppresses atrophy- and autophagy-related genes in heart tissue and cardiomyocytes through AKT/FOXO signaling.
2	23757118	Insulin is an important regulator of the ubiquitin-proteasome system (UPS) and of lysosomal proteolysis in cardiac muscle.
3	23757118	However, the role of insulin in the regulation of the muscle atrophy-related Ub-ligases atrogin-1 and MuRF1 as well as in autophagy, a major adaptive response to nutritional stress, in the heart has not been characterized.
4	23757118	We report here that acute insulin deficiency in the cardiac muscle of rats induced by streptozotocin increased the expression of atrogin-1 and MuRF1 as well as LC3 and Gabarapl1, 2 autophagy-related genes.
5	23757118	These effects were associated with decreased phosphorylation levels of Akt and its downstream target Foxo3a; this phenomenon is a well-known effect that permits the maintenance of Foxo in the nucleus to activate protein degradation by proteasomal and autophagic processes.
6	23757118	The administration of insulin increased Akt and Foxo3a phosphorylation and suppressed the diabetes-induced expression of Ub-ligases and autophagy-related genes.
7	23757118	Furthermore, the addition of insulin in vitro prevented the decrease in Akt/Foxo signaling induced by nutritional stress.
8	23757118	These findings demonstrate that insulin suppresses atrophy- and autophagy-related genes in heart tissue and cardiomyocytes, most likely through the phosphorylation of Akt and the inactivation of Foxo3a.