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Gene Information
Gene symbol: GCLM
Gene name: glutamate-cysteine ligase, modifier subunit
HGNC ID: 4312
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GCA | 1 hits |
| 2 | GCLC | 1 hits |
| 3 | MAFK | 1 hits |
| 4 | NFE2L2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17109620 | NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglycemia- induced brain endothelial cell apoptosis. |
| 2 | 17109620 | Insulin stimulated glutamate-L-cysteine ligase (GCL) activity by activation of phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR signaling, increased serine phosphorylation and nuclear translocation of nuclear NF-E2-related factor 2 (Nrf2), and upregulation of Nrf2-dependent GCL-catalytic (GCLc) subunit expression. |
| 3 | 17109620 | Expression of the GCL-modulatory subunit (GCLm) was unchanged. |
| 4 | 17109620 | Inhibitors of insulin receptor tyrosine kinase, PI3K, Akt and mTOR abrogated insulin-induced Nrf2-mediated GCLc expression, redox balance, and IHEC survival. |
| 5 | 17109620 | Activation of insulin signaling through PI3K/Akt/mTOR/Nrf2/ GCLc pathway affords significant cell protection by maintaining cellular redox balance. |
| 6 | 23547261 | The expression of the master antioxidant regulatory factor Nrf2 (nuclear factor erythroid 2-related factor 2) and its targets, Sesn2, Prdx3, Gclc, and Gclm, was decreased in β-Bmal1(-/-) islets, which may contribute to the observed increase in ROS accumulation. |