Ignet

Gene Information

Gene symbol: GDF2

Gene name: growth differentiation factor 2

HGNC ID: 4217

Synonyms: BMP-9, BMP9

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	AKT2	1 hits
3	BMP2	1 hits
4	INS	1 hits
5	PCK2	1 hits
6	SMAD5	1 hits

Related Sentences

#	PMID	Sentence
1	12598908	Bone morphogenetic protein-9 (BMP-9) gave a positive response in two independent assays: reducing phosphoenolpyruvate carboxykinase (PEPCK) expression in hepatocytes and activating Akt kinase in differentiated myotubes.
2	20079400	Smad5 regulates Akt2 expression and insulin-induced glucose uptake in L6 myotubes.
3	20079400	Insulin-induced glucose uptake by skeletal muscle results from Akt2 activation and is severely impaired during insulin resistance.
4	20079400	However, the mechanism by which BMP9 modulates insulin action remains unknown.
5	20079400	Here we demonstrate that Smad5, a transcription factor activated by BMP9, and Akt2, are upregulated in differentiated L6 myotubes.
6	20079400	Smad5, rather than Smad1/8, is downregulated "in vivo" and "in vitro" by dexamethasone.
7	20079400	Smad5 knockdown decreased Akt2 expression and serine phosphorylation and insulin-induced glucose uptake, and increased the expression of the lipid phosphatase Ship2.
8	20079400	Additionally, binding of Smad5 to Akt2 gene is decreased in dexamethasone-treated rats and increased in L6 myotubes compared to myoblasts.
9	20079400	The present study indicates that Smad5 regulates glucose uptake in skeletal muscle by controlling Akt2 expression and phosphorylation.
10	20079400	Smad5 regulates Akt2 expression and insulin-induced glucose uptake in L6 myotubes.
11	20079400	Insulin-induced glucose uptake by skeletal muscle results from Akt2 activation and is severely impaired during insulin resistance.
12	20079400	However, the mechanism by which BMP9 modulates insulin action remains unknown.
13	20079400	Here we demonstrate that Smad5, a transcription factor activated by BMP9, and Akt2, are upregulated in differentiated L6 myotubes.
14	20079400	Smad5, rather than Smad1/8, is downregulated "in vivo" and "in vitro" by dexamethasone.
15	20079400	Smad5 knockdown decreased Akt2 expression and serine phosphorylation and insulin-induced glucose uptake, and increased the expression of the lipid phosphatase Ship2.
16	20079400	Additionally, binding of Smad5 to Akt2 gene is decreased in dexamethasone-treated rats and increased in L6 myotubes compared to myoblasts.
17	20079400	The present study indicates that Smad5 regulates glucose uptake in skeletal muscle by controlling Akt2 expression and phosphorylation.
18	22073163	Further, we find several additional ligands, AB204, AB211, and AB215, which initiate the intracellular Smad1-mediated signaling pathways more strongly than BMP-2 but show no sensitivity to the natural BMP antagonist Noggin unlike natural BMP-2.
19	22073163	In another design, incorporation of a short N-terminal segment from BMP-2 was sufficient to enable chemical refolding of BMP-9, without which was never produced nor refolded.