Ignet

Gene Information

Gene symbol: GJA8

Gene name: gap junction protein, alpha 8, 50kDa

HGNC ID: 4281

Synonyms: CX50

Related Genes

#	Gene Symbol	Number of hits
1	CD36	1 hits
2	CD4	1 hits
3	CD44	1 hits
4	F2	1 hits
5	GJA1	1 hits
6	GJB1	1 hits
7	GJB2	1 hits
8	ICAM1	1 hits
9	IL1B	1 hits
10	MSR1	1 hits
11	NLRP3	1 hits
12	OLR1	1 hits
13	SCARB1	1 hits
14	THBD	1 hits
15	THY1	1 hits

Related Sentences

#	PMID	Sentence
1	1360342	Insulin-dependent diabetes mellitus (IDDM) results from a T cell-dependent autoimmune destruction of insulin-producing pancreatic beta cells.
2	1360342	Freshly isolated pancreatic beta cells from ob/ob mice did not express ICAM-1, but treatment of the cells with IL-1-beta, TNF-alpha, or INF-gamma strongly induced its expression as measured by immunofluorescence flow cytometry.
3	1360342	Immunoprecipitation from IL-1-beta-treated beta cells demonstrated a cell-surface glycoprotein with an apparent molecular weight of 95 kDa.
4	1737783	Human CD4, a monomeric T cell surface glycoprotein, is required for T helper cell activation and is also the receptor for the human immunodeficiency virus.
5	2687874	CD4 is a T-cell surface glycoprotein and serves as the receptor for the human immunodeficiency virus.
6	3259951	The T-cell surface glycoprotein CD4 plays an important role in mediating cellular immunity and serves as the receptor for human immunodeficiency virus.
7	7525471	The gene of the CD44 cell surface glycoprotein consists of 20 exons.
8	8051797	Thrombomodulin is an endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin.
9	8051797	Thus thrombomodulin converts thrombin from a procoagulant protease to an anticoagulant.
10	8527803	THY1 gene encodes a cell surface glycoprotein predominantly expressed in brain and peripheral nerves.
11	12473645	FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.
12	12473645	Receptors for AGEs include scavenger receptors, which recognize acetylated low density lipoproteins (Ac-LDL) such as scavenger receptor class AI/AII (SR-A), cell surface glycoprotein CD36, scavenger receptor class B type I (SR-BI), and lectin-like oxidized low density lipoprotein receptor-1.
13	12473645	The broad ligand repertoire of these receptors as well as the diversity of the receptors for AGEs have prompted us to examine whether AGEs are also recognized by the novel scavenger receptors, which we have recently isolated from a cDNA library prepared from human umbilical vein endothelial cells, such as the scavenger receptor expressed by endothelial cells-I (SREC-I); the fasciclin EGF-like, laminin-type EGF-like, and link domain-containing scavenger receptor-1 (FEEL-1); and its paralogous protein, FEEL-2.
14	12473645	At 4 degrees C, (125)I-AGE-bovine serum albumin (BSA) exhibited high affinity specific binding to Chinese hamster ovary (CHO) cells overexpressing FEEL-1 (CHO-FEEL-1) and FEEL-2 (CHO-FEEL-2) with K(d) of 2.55 and 1.68 microg/ml, respectively, but not to CHO cells expressing SREC (CHO-SREC) and parent CHO cells.
15	12473645	At 37 degrees C, (125)I-AGE-BSA was taken up and degraded by CHO-FEEL-1 and CHO-FEEL-2 cells but not by CHO-SREC and parent CHO cells.
16	12473645	The (125)I-AGE-BSA binding to CHO-FEEL-1 and CHO-FEEL-2 cells was effectively inhibited by Ac-LDL and polyanionic SR-A inhibitors such as fucoidan, polyinosinic acids, and dextran sulfate but not by native LDL, oxidized LDL, or HDL.
17	17102126	We studied the expression of Cx26, Cx32, Cx43, and Cx50 in chromaffin cells of 10 normal human adrenal glands, 10 benign, and 13 malignant pheochromocytomas.
18	17102126	Immunohistochemistry showed that Cx50 expression seemed to be the predominant form of Cx expressed in human chromaffin cells, whereas Cx43 immunoreactivity was the most prominent form found in the adrenal cortex.
19	17102126	Cx26 and Cx32 were distributed inhomogeneously with no emphasis of expression in the types of tissues studied.
20	17102126	We studied the expression of Cx26, Cx32, Cx43, and Cx50 in chromaffin cells of 10 normal human adrenal glands, 10 benign, and 13 malignant pheochromocytomas.
21	17102126	Immunohistochemistry showed that Cx50 expression seemed to be the predominant form of Cx expressed in human chromaffin cells, whereas Cx43 immunoreactivity was the most prominent form found in the adrenal cortex.
22	17102126	Cx26 and Cx32 were distributed inhomogeneously with no emphasis of expression in the types of tissues studied.
23	23346076	Intercellular adhesion molecule 1 (ICAM1) is a cell surface glycoprotein expressed on endothelial cells and leukocytes in the immune system.