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Gene Information
Gene symbol: GNA13
Gene name: guanine nucleotide binding protein (G protein), alpha 13
HGNC ID: 4381
Synonyms: G13, MGC46138
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | JUN | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15492006 | G alpha 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formation. |
| 2 | 15492006 | The heterotrimeric G-protein G(13) mediates the formation of primitive endoderm from mouse P19 embryonal carcinoma cells in response to retinoic acid, signaling to the level of activation of c-Jun N-terminal kinase. |
| 3 | 15492006 | The signal linkage map from MEKK1/MEKK4 to MEK1/MKK4 to JNK is obligate in this G alpha(13)-mediated pathway, whereas that between G alpha(13) and MEKKs is not known. |
| 4 | 15492006 | Constitutively active G alpha(13) was found to activate RhoA as well as Cdc42 and Rac1 in these cells. |
| 5 | 15492006 | Although constitutively active Cdc42, Rac1, and RhoA all can activate JNK1, only the RhoA mutant was able to promote formation of primitive endoderm, mimicking expression of the constitutively activated G alpha(13). |
| 6 | 15492006 | Expression of the constitutively active mutant form of p115RhoGEF (guanine nucleotide exchange factor) was found to activate RhoA and JNK1 activities. |
| 7 | 15492006 | Expression of the dominant negative p115RhoGEF was able to inhibit activation of both RhoA and JNK1 in response to either retinoic acid or the expression of a constitutively activated mutant of G alpha(13). |
| 8 | 15492006 | Expression of the dominant negative mutants of RhoA as well as those of either Cdc42 or Rac1, but not Ras, attenuated G alpha(13)-stimulated as well as retinoic acid-stimulated activation of all three of these small molecular weight GTPases, suggesting complex interrelationships among the three GTPases in this pathway. |
| 9 | 15492006 | The formation of primitive endoderm in response to retinoic acid also could be blocked by expression of dominant negative mutants of RhoA, Cdc42, or Rac1. |
| 10 | 15492006 | Thus, the signal propagated from G alpha(13) to JNK requires activation of p115RhoGEF cascades, including p115RhoGEF itself, RhoA, Cdc42, and Rac1. |
| 11 | 15492006 | In a concerted effort, RhoA in tandem with Cdc42 and Rac1 activates the MEKK1/4, MEK1/MKK4, and JNK cascade, thereby stimulating formation of primitive endoderm. |