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Gene Information
Gene symbol: GOLPH3
Gene name: golgi phosphoprotein 3 (coat-protein)
HGNC ID: 15452
Synonyms: GPP34, GOPP1, MIDAS
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACBD3 | 1 hits |
| 2 | FASN | 1 hits |
| 3 | SREBF1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23166793 | Maturation and activity of sterol regulatory element binding protein 1 is inhibited by acyl-CoA binding domain containing 3. |
| 2 | 23166793 | In the present study, we found that overexpressed acyl-CoA binding domain containing 3 (ACBD3), a Golgi-associated protein, dramatically inhibited SREBP1-sensitive promoter activity of fatty acid synthase (FASN). |
| 3 | 23166793 | Moreover, lipid deprivation-stimulated SREBP1 maturation was significantly attenuated by ACBD3. |
| 4 | 23166793 | With cell fractionation, gene knockdown and immunoprecipitation assays, it was showed that ACBD3 blocked intracellular maturation of SREBP1 probably through directly binding with the lipid regulator rather than disrupted SREBP1-SCAP-Insig1 interaction. |
| 5 | 23166793 | Further investigation revealed that acyl-CoA domain-containing N-terminal sequence of ACBD3 contributed to its inhibitory effects on the production of nuclear SREBP1. |
| 6 | 23166793 | In addition, mRNA and protein levels of FASN and de novo palmitate biosynthesis were remarkably reduced in cells overexpressed with ACBD3. |