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Gene Information
Gene symbol: GOPC
Gene name: golgi-associated PDZ and coiled-coil motif containing
HGNC ID: 17643
Synonyms: dJ94G16.2, PIST, FIG, GOPC1, CAL
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ASPSCR1 | 1 hits |
| 2 | INADL | 1 hits |
| 3 | INS | 1 hits |
| 4 | VWF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11947908 | Among subjects with a CAL, after controlling for the above risk factors as well as mean far wall intima-media thickness, AS was associated with higher levels of von Willebrand factor [OR=1.38 (95% CI: 1.10, 1.74)], a marker of endothelial activation. |
| 2 | 23744065 | Insulin stimulates glucose uptake in 3T3-L1 adipocytes in part by causing endoproteolytic cleavage of TUG (tether containing a ubiquitin regulatory X (UBX) domain for glucose transporter 4 (GLUT4)). |
| 3 | 23744065 | UBX-Cter expression caused depletion of PIST (PDZ domain protein interacting specifically with TC10), which transmits an insulin signal to TUG. |
| 4 | 23744065 | Whereas insulin stimulated TUG proteolysis in control muscles, proteolysis was constitutive in transgenic muscles. |
| 5 | 23744065 | We conclude that insulin stimulates TUG proteolysis to translocate GLUT4 in muscle, that this pathway impacts systemic glucose homeostasis and energy metabolism, and that the effects of activating this pathway are maintained during high fat diet-induced insulin resistance in mice. |