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Gene Information
Gene symbol: GPC3
Gene name: glypican 3
HGNC ID: 4451
Synonyms: OCI-5, SGBS, SGBS1, SGB, DGSX
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD44 | 1 hits |
| 2 | CGB | 1 hits |
| 3 | GPC1 | 1 hits |
| 4 | GPC2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11193214 | The expression of glypican-3 (GPC3), a heparan-sulfate proteoglycan associated with the Simpson-Golabi-Behmel fetal overgrowth syndrome, was studied in normal human placental tissue and cell lines derived from human placentae. |
| 2 | 11454708 | In contrast, the expression of glypican-3 and -4 is only slightly increased in breast cancers by comparison with normal breast tissues, and glypican-2 and -5 are below the level of detection by Northern blotting in both normal and cancer samples. |
| 3 | 11454708 | Treatment of MDA-MB-231 and MDA-MB-468 breast cancer cells with phosphoinositide-specific phospholipase-C abrogated the mitogenic response to two heparin-binding growth factors, heparin-binding epidermal growth factor-like growth factor and fibroblast growth factor 2. |
| 4 | 11454708 | Stable transfection of these cells with a glypican-1 antisense construct markedly decreased glypican-1 protein levels and the mitogenic response to the same heparin-binding growth factors, as well as that to heregulin alpha, heregulin beta, and hepatocyte growth factor. |
| 5 | 11454708 | There was a good correlation between glypican-1 and syndecan-1 expression in the tumors. |
| 6 | 11454708 | However, clones expressing the glypican-1 antisense construct did not exhibit decreased syndecan-1 levels, indicating that loss of responsiveness to heparin-binding growth factors in these clones was not due to altered syndecan-1 expression. |
| 7 | 16158429 | The Simpson-Golabi-Behmel syndrome (SGBS) (OMIM 312870) is an overgrowth/multiple congenital anomalies syndrome caused by a semi-dominant X-linked gene encoding glypican 3 (GPC3). |
| 8 | 18203194 | Molecular genetic analysis revealed the p.Gly556Arg mutation in exon 8 of the gene encoding glypican 3 (GPC3). |
| 9 | 18457360 | By using male Wistar rats injected with saline (normal rats) or nicotinamide plus streptozotocin (diabetic rats), we investigated the effects of an orally ingested placebo (CON and STZ groups), culture mycelium (CGM and SGM groups), broth (CGB and SGB groups), and mycelium plus broth (CGX and SGX groups) of Grifola frondosa on glycemic responses. |