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Gene Information
Gene symbol: GPR182
Gene name: G protein-coupled receptor 182
HGNC ID: 13708
Synonyms: hrhAMR, G10D, AM-R
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CALCA | 1 hits |
| 2 | CALCR | 1 hits |
| 3 | CALCRL | 1 hits |
| 4 | CFH | 1 hits |
| 5 | FFAR1 | 1 hits |
| 6 | INS | 1 hits |
| 7 | MAPK1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12667633 | The AM receptor, a complex formed by calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs), and the recently discovered AM-binding protein, complement factor H (fH), are expressed in the insulin-producing beta-cells. |
| 2 | 16495482 | Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothelial cells and induce its desensitisation by different mechanisms. |
| 3 | 16495482 | Adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) are related peptides with distinct pharmacological profiles. |
| 4 | 16495482 | Calcitonin-receptor-like receptor (CRLR, now known as CL) can function as either an AM receptor or a CGRP receptor, when cotransfected with receptor-activity-modifying proteins (RAMPs) that define ligand-binding specificity. |
| 5 | 16495482 | Cultured MVECs continue to express EndoCL as well as fully active endogenous AM- and CGRP-sensitive receptors in vitro, as demonstrated by the ability of both peptides to induce migration and Akt phosphorylation. |
| 6 | 16495482 | We therefore tested the hypothesis that endothelial EndoCL can interact with both AM and CGRP by examining receptor internalisation and desensitisation (loss of the ability to induce Akt phosphorylation). |
| 7 | 16870702 | We also show that pathways controlling seven-transmembrane receptor (7-TMR) ERK2 activation/deactivation function independently of G proteins and ligand-induced production of intracellular cAMP and the consequent activation of PKA. |
| 8 | 23631851 | A decade ago, the seven-transmembrane domain receptor (7TMR) GPR40 was demonstrated to be predominantly expressed in β cells and activated by long-chain FFAs. |
| 9 | 23631851 | Furthermore, GPR40 has drawn considerable interest as a novel therapeutic target to enhance insulin secretion in type 2 diabetes. |