Ignet

Gene Information

Gene symbol: GPRC5C

Gene name: G protein-coupled receptor, family C, group 5, member C

HGNC ID: 13309

Synonyms: RAIG-3

Related Genes

#	Gene Symbol	Number of hits
1	BRS3	1 hits
2	CASR	1 hits
3	CYSLTR2	1 hits
4	FFAR1	1 hits
5	GPR119	1 hits
6	GPR120	1 hits
7	GPR55	1 hits
8	GPR84	1 hits
9	GPRC6A	1 hits
10	GRP	1 hits
11	LPAR5	1 hits
12	SUCNR1	1 hits
13	TAS1R1	1 hits
14	TAS1R2	1 hits
15	TAS1R3	1 hits
16	UTS2	1 hits
17	UTS2D	1 hits
18	UTS2R	1 hits

Related Sentences

#	PMID	Sentence
1	15141213	Here we show that GPR91 (ref. 3), a previously orphan G-protein-coupled receptor (GPCR), functions as a receptor for the citric acid cycle intermediate succinate.
2	15141213	We also report that GPR99 (ref. 4), a close relative of GPR91, responds to alpha-ketoglutarate, another intermediate in the citric acid cycle.
3	15141213	The succinate-induced hypertensive effect involves the renin-angiotensin system and is abolished in GPR91-deficient mice.
4	16966319	Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84.
5	16966319	Here we show that GPR84, a previously orphan G protein-coupled receptor, functions as a receptor for medium-chain FFAs with carbon chain lengths of 9-14.
6	16966319	Furthermore, we demonstrate that medium-chain FFAs amplify lipopolysaccharide-stimulated production of the proinflammatory cytokine interleukin-12 p40 through GPR84.
7	16966319	Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84.
8	16966319	Here we show that GPR84, a previously orphan G protein-coupled receptor, functions as a receptor for medium-chain FFAs with carbon chain lengths of 9-14.
9	16966319	Furthermore, we demonstrate that medium-chain FFAs amplify lipopolysaccharide-stimulated production of the proinflammatory cytokine interleukin-12 p40 through GPR84.
10	17699519	GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have recently been identified as free fatty acids (FFAs).
11	17931747	Urotensin II (U-II) and urotensin II-related peptide (URP) are the endogenous ligands for the orphan G-protein-coupled receptor GPR14 now renamed UT.
12	17931747	At the periphery, U-II and/or URP exert a wide range of biological effects on cardiovascular tissues, airway smooth muscles, kidney and endocrine glands, while central administration of U-II elicits various behavioral and cardiovascular responses.
13	17931747	There is also evidence that U-II and/or URP may be involved in a number of pathological conditions including heart failure, atherosclerosis, renal dysfunction and diabetes.
14	18698756	Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119.
15	18698756	GPR119 is a rhodopsin-like GPCR expressed in pancreatic beta-cells and incretin releasing cells in the GI tract.
16	21094899	This has led to the hypothesis that these receptors may act as sensors of food intake modulating, for example, release of incretin hormones from the gut, insulin/glucagon from the pancreas, and leptin from adipose tissue.
17	21094899	In the present review, we describe the molecular mechanisms of nutrient-sensing of the calcium-sensing receptor (CaR), the G protein-coupled receptor family C, group 6, subtype A (GPRC6A), and the taste1 receptor T1R1/T1R3-sensing L-α-amino acids; the carbohydrate-sensing T1R2/T1R3 receptor; the proteolytic degradation product sensor GPR93 (also termed GPR92); and the FFA sensing receptors FFA1, FFA2, FFA3, GPR84, and GPR120.
18	21354793	Bombesin receptor subtype-3 (BRS-3) is an orphan G-protein coupled receptor belonging to the subfamily of bombesin-like receptors.
19	21354793	We describe the discovery of 2a, which has mid-nanomolar potency, selectivity for human BRS-3 versus the other bombesin-like receptors, and good bioavailability.
20	21444206	Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.
21	21444206	We herein outline the design of a new series of agonists of the pancreatic and GI-expressed orphan G-protein coupled receptor GPR119, a target that has been of significant recent interest in the field of metabolism, starting from our prototypical agonist AR231453.
22	21444206	Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.
23	21444206	We herein outline the design of a new series of agonists of the pancreatic and GI-expressed orphan G-protein coupled receptor GPR119, a target that has been of significant recent interest in the field of metabolism, starting from our prototypical agonist AR231453.
24	23679955	Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold.
25	23679955	The orphan G-protein-coupled receptor GPR55, which is activated by 1-lysophosphatidylinositol and interacts with cannabinoid (CB) receptor ligands, has been proposed as a new potential drug target for the treatment of diabetes, Parkinson's disease, neuropathic pain, and cancer.
26	23679955	Selectivity versus the related receptors CB1, CB2, and GPR18 was assessed.
27	23679955	Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold.
28	23679955	The orphan G-protein-coupled receptor GPR55, which is activated by 1-lysophosphatidylinositol and interacts with cannabinoid (CB) receptor ligands, has been proposed as a new potential drug target for the treatment of diabetes, Parkinson's disease, neuropathic pain, and cancer.
29	23679955	Selectivity versus the related receptors CB1, CB2, and GPR18 was assessed.
30	19487246	These receptors thus hold the potential to act as sensors of food intake, regulating, for example, release of incretin hormones from the gut, insulin/glucagon from the pancreas, and leptin from adipose tissue.
31	19487246	We here review the molecular mechanisms of nutrient sensing of the calcium-sensing receptor, the G protein-coupled receptor family C, group 6, subtype A (GPRC6A), and the taste1 receptor T1R1/T1R3, which are sensing L-alpha-amino acids, the carbohydrate-sensing T1R2/T1R3 receptor, the proteolytic degradation product sensor GPR93 (also termed GPR92), and the free fatty acid (FFA) sensing receptors FFA1, FFA2, FFA3, GPR84, and GPR120.