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Gene Information
Gene symbol: GPSN2
Gene name: glycoprotein, synaptic 2
HGNC ID: 4551
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CYBB | 1 hits |
| 2 | TJP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23437353 | Effect of 12- or 15-HETE on the levels of zonula occludens protein 1 (ZO-1), reactive oxygen species (ROS), NOX2, pVEGF-R2 and pSHP1 was examined in the presence or absence of inhibitors of NADPH oxidase. |
| 2 | 23437353 | ROS generation and NOX2 expression were also measured in mice retinas. 12- and 15- HETE significantly increased permeability and reduced TER and ZO-1 expression in REC. |
| 3 | 23437353 | Treatment of diabetic mice with baicalein significantly decreased retinal HETE, ICAM-1, VCAM-1, IL-6, ROS generation, and NOX2 expression. |
| 4 | 23437353 | Our findings suggest that 12/15-LOX contributes to vascular hyperpermeability during DR via NADPH oxidase dependent mechanism which involves suppression of protein tyrosine phosphatase and activation of VEGF-R2 signal pathway. |