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Gene Information

Gene symbol: GRHPR

Gene name: glyoxylate reductase/hydroxypyruvate reductase

HGNC ID: 4570

Synonyms: PH2

Related Genes

#	Gene Symbol	Number of hits
1	AGXT	1 hits
2	FOXA2	1 hits

Related Sentences

#	PMID	Sentence
1	11272196	PDX-1 was shown to be expressed early during development in cells of both exocrine and endocrine origin; later it becomes restricted primarily to beta-cells where it regulates the expression of beta-cell-specific genes and mediates the glucose effect on insulin gene transcription.
2	11272196	This comparison revealed three short conserved regions, designated PH1, PH2, and PH3.
3	11272196	We showed that HNF-3beta can bind and stimulate the activity of the human PH1 and PH2 elements in non-beta-cells.
4	11272196	Results reported by Wu et al. (7) and Sharma et al. (6) also indicate that expression of the mouse pdx-1 is controlled by an HNF-3-like element.
5	11272196	Thus, it can be stated that at least some aspects of pdx-1 expression rely on the transcription factor HNF-3beta.
6	11272196	Because HNF-3beta is not restricted to beta-cells, the selective transcription of pdx-1 is likely to rely on additional factors.
7	11272196	Our findings that the PH1 enhancer element binds both HNF-3beta and PDX-1 and that mutations in each individual site dramatically impair its transcriptional activity suggest that these factors cooperate with one another.
8	11272196	PDX-1 was shown to be expressed early during development in cells of both exocrine and endocrine origin; later it becomes restricted primarily to beta-cells where it regulates the expression of beta-cell-specific genes and mediates the glucose effect on insulin gene transcription.
9	11272196	This comparison revealed three short conserved regions, designated PH1, PH2, and PH3.
10	11272196	We showed that HNF-3beta can bind and stimulate the activity of the human PH1 and PH2 elements in non-beta-cells.
11	11272196	Results reported by Wu et al. (7) and Sharma et al. (6) also indicate that expression of the mouse pdx-1 is controlled by an HNF-3-like element.
12	11272196	Thus, it can be stated that at least some aspects of pdx-1 expression rely on the transcription factor HNF-3beta.
13	11272196	Because HNF-3beta is not restricted to beta-cells, the selective transcription of pdx-1 is likely to rely on additional factors.
14	11272196	Our findings that the PH1 enhancer element binds both HNF-3beta and PDX-1 and that mutations in each individual site dramatically impair its transcriptional activity suggest that these factors cooperate with one another.
15	21304260	The activity of serine : pyruvate/alanine : glyoxylate aminotransferase (SPT/AGT) or glyoxylate reductase/hydroxypyruvate reductase (GRHPR), the key enzyme of primary hyperoxlauria type 1 and 2, respectively, and their subcellular distribution highly affects the oxalate production.