Ignet

Gene Information

Gene symbol: GRIN2A

Gene name: glutamate receptor, ionotropic, N-methyl D-aspartate 2A

HGNC ID: 4585

Synonyms: GluN2A

Related Genes

#	Gene Symbol	Number of hits
1	ANGPTL1	1 hits
2	CAMK2G	1 hits
3	DLG4	1 hits
4	GRIA1	1 hits
5	GRIN1	1 hits
6	GRIN2B	1 hits
7	INS	1 hits
8	LHCGR	1 hits
9	PSD	1 hits
10	SFRP4	1 hits
11	SOCS3	1 hits
12	TNIK	1 hits

Related Sentences

#	PMID	Sentence
1	10443587	N-methyl-D-aspartate (NMDA) subunits NR2A and NR2B, bind to the PSD protein called PSD-95, which in turn binds neuroligins, providing a handle for interacting with neurexin, located in the plasma membrane at the presynaptic active zone.
2	11908465	In contrast, 4 months after induction of diabetes NR2B subunit immunoreactivity, CaMKII and Tyr-dependent phosphorylation of the NR2A/B subunits of the NMDA receptor were reduced and alphaCaMKII autophosphorylation and its association to the NMDA receptor complex were impaired in STZ-rats compared with age-matched controls.
3	11908465	Insulin treatment prevented the reduction in kinase activities, NR2B expression levels, CaMKII-NMDA receptor association and NMDA currents.
4	12009768	Immunoblot analyses showed that levels of the N-methyl-d-aspartate (NMDA) subunits NR1 and NR2A were significantly decreased in neurons exposed to phenformin, whereas levels of the AMPA receptor subunit GluR1 were unchanged.
5	14754663	This study examined the effects of streptozotocin-diabetes and insulin or gliclazide treatment on the hippocampal NMDA receptor subunit 2A and 2B (NR2A and NR2B) concentrations.
6	14754663	Eight weeks after the induction of diabetes MDA, levels were increased, and NR2A and NR2B concentrations were reduced.
7	14754663	Insulin and gliclazide treatment partially prevented the reduction of NR2A and NR2B expression and prevented the elevation of MDA levels.
8	14754663	This study examined the effects of streptozotocin-diabetes and insulin or gliclazide treatment on the hippocampal NMDA receptor subunit 2A and 2B (NR2A and NR2B) concentrations.
9	14754663	Eight weeks after the induction of diabetes MDA, levels were increased, and NR2A and NR2B concentrations were reduced.
10	14754663	Insulin and gliclazide treatment partially prevented the reduction of NR2A and NR2B expression and prevented the elevation of MDA levels.
11	14754663	This study examined the effects of streptozotocin-diabetes and insulin or gliclazide treatment on the hippocampal NMDA receptor subunit 2A and 2B (NR2A and NR2B) concentrations.
12	14754663	Eight weeks after the induction of diabetes MDA, levels were increased, and NR2A and NR2B concentrations were reduced.
13	14754663	Insulin and gliclazide treatment partially prevented the reduction of NR2A and NR2B expression and prevented the elevation of MDA levels.
14	15370192	NR2A and NR2B protein concentrations were significantly decreased by about 30% in diabetic rats.
15	15370192	Dietary LC-PUFAs partially restored NR2A and NR2B in diabetic rats whereas the most significant increase was seen in nondiabetic rats.
16	15370192	NR2A and NR2B protein concentrations were significantly decreased by about 30% in diabetic rats.
17	15370192	Dietary LC-PUFAs partially restored NR2A and NR2B in diabetic rats whereas the most significant increase was seen in nondiabetic rats.
18	15893611	The levels of mRNAs coding for AMPA receptor subunits, GluR1, GluR2, and GluR3, were significantly increased in all layers (laminae I-V) of the dorsal horn in diabetic (STZ-injected) rats compared to control (vehicle-injected) rats.
19	15893611	The hybridization signals for NR2A mRNA and NR2B mRNA were significantly elevated in the deep layer of the dorsal horn of diabetic rats.
20	15893611	In diabetic (STZ-induced) rats, the levels of expression of mGluR1 mRNA and mGluR5 mRNA were significantly increased in all layers of the dorsal horn.
21	23603633	According to the different expression levels in the microarrays and their putative functions, six differentially expressed genes (LHCGR, ANGPTL1, TNIK, GRIN2A, SFRP4, and SOCS3) were selected and analyzed by quantitative RT-PCR (qRT-PCR).
22	23603633	Moreover, the molecular signatures (LHCGR, TNIK, and SOCS3) were associated with developmental potential from embryo to blastocyst stage and were proposed as biomarkers of embryo viability in PCOS patients.