Ignet

Gene Information

Gene symbol: GRIN2B

Gene name: glutamate receptor, ionotropic, N-methyl D-aspartate 2B

HGNC ID: 4586

Synonyms: GluN2B

Related Genes

#	Gene Symbol	Number of hits
1	CAMK2G	1 hits
2	DLG4	1 hits
3	GRIN2A	1 hits
4	HDAC2	1 hits
5	INS	1 hits
6	IRS1	1 hits
7	PSD	1 hits

Related Sentences

#	PMID	Sentence
1	10443587	N-methyl-D-aspartate (NMDA) subunits NR2A and NR2B, bind to the PSD protein called PSD-95, which in turn binds neuroligins, providing a handle for interacting with neurexin, located in the plasma membrane at the presynaptic active zone.
2	11908465	In contrast, 4 months after induction of diabetes NR2B subunit immunoreactivity, CaMKII and Tyr-dependent phosphorylation of the NR2A/B subunits of the NMDA receptor were reduced and alphaCaMKII autophosphorylation and its association to the NMDA receptor complex were impaired in STZ-rats compared with age-matched controls.
3	11908465	Insulin treatment prevented the reduction in kinase activities, NR2B expression levels, CaMKII-NMDA receptor association and NMDA currents.
4	11908465	In contrast, 4 months after induction of diabetes NR2B subunit immunoreactivity, CaMKII and Tyr-dependent phosphorylation of the NR2A/B subunits of the NMDA receptor were reduced and alphaCaMKII autophosphorylation and its association to the NMDA receptor complex were impaired in STZ-rats compared with age-matched controls.
5	11908465	Insulin treatment prevented the reduction in kinase activities, NR2B expression levels, CaMKII-NMDA receptor association and NMDA currents.
6	14754663	This study examined the effects of streptozotocin-diabetes and insulin or gliclazide treatment on the hippocampal NMDA receptor subunit 2A and 2B (NR2A and NR2B) concentrations.
7	14754663	Eight weeks after the induction of diabetes MDA, levels were increased, and NR2A and NR2B concentrations were reduced.
8	14754663	Insulin and gliclazide treatment partially prevented the reduction of NR2A and NR2B expression and prevented the elevation of MDA levels.
9	14754663	This study examined the effects of streptozotocin-diabetes and insulin or gliclazide treatment on the hippocampal NMDA receptor subunit 2A and 2B (NR2A and NR2B) concentrations.
10	14754663	Eight weeks after the induction of diabetes MDA, levels were increased, and NR2A and NR2B concentrations were reduced.
11	14754663	Insulin and gliclazide treatment partially prevented the reduction of NR2A and NR2B expression and prevented the elevation of MDA levels.
12	14754663	This study examined the effects of streptozotocin-diabetes and insulin or gliclazide treatment on the hippocampal NMDA receptor subunit 2A and 2B (NR2A and NR2B) concentrations.
13	14754663	Eight weeks after the induction of diabetes MDA, levels were increased, and NR2A and NR2B concentrations were reduced.
14	14754663	Insulin and gliclazide treatment partially prevented the reduction of NR2A and NR2B expression and prevented the elevation of MDA levels.
15	15370192	NR2A and NR2B protein concentrations were significantly decreased by about 30% in diabetic rats.
16	15370192	Dietary LC-PUFAs partially restored NR2A and NR2B in diabetic rats whereas the most significant increase was seen in nondiabetic rats.
17	15370192	NR2A and NR2B protein concentrations were significantly decreased by about 30% in diabetic rats.
18	15370192	Dietary LC-PUFAs partially restored NR2A and NR2B in diabetic rats whereas the most significant increase was seen in nondiabetic rats.
19	15893611	The levels of mRNAs coding for AMPA receptor subunits, GluR1, GluR2, and GluR3, were significantly increased in all layers (laminae I-V) of the dorsal horn in diabetic (STZ-injected) rats compared to control (vehicle-injected) rats.
20	15893611	The hybridization signals for NR2A mRNA and NR2B mRNA were significantly elevated in the deep layer of the dorsal horn of diabetic rats.
21	15893611	In diabetic (STZ-induced) rats, the levels of expression of mGluR1 mRNA and mGluR5 mRNA were significantly increased in all layers of the dorsal horn.
22	22733364	Co-location of HDAC2 and insulin signaling components in the adult mouse hippocampus.
23	22733364	However, the recent studies indicated that HDAC2, a member of HDACs family, played a role in insulin signaling pathway and synaptic plasticity.
24	22733364	Here, we are concerned about whether HDAC2 was co-located with insulin signaling components in postsynaptic glutamatergic neurons (PSGNs) of the adult mouse hippocampus using double immunofluorescence staining.
25	22733364	The results displayed that HDAC2 was present in PSGNs marked by N-methyl-D-aspartate receptor subunit 2B, in which major components of insulin signaling pathway such as insulin receptor alpha and beta and insulin receptor substrate-1 were also involved.
26	22733364	Accordingly, we speculate that the interaction of HDAC2 and insulin signaling system in PSGNs observed in the present study may serve as a potential mechanism in memory formation.
27	22733364	We hope this could provide a valuable basis for understanding the roles of HDAC2 and insulin on cognitive impairment of diabetes mellitus, involved Alzheimer's disease, which is also called type 3 diabetes recently.