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Gene Information
Gene symbol: GSC
Gene name: goosecoid homeobox
HGNC ID: 4612
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FOXA2 | 1 hits |
| 2 | MIXL1 | 1 hits |
| 3 | NUDT6 | 1 hits |
| 4 | SOX17 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21855631 | In this study, we describe the roles of growth factors bFGF, BMP4 and Activin A in early hESC fate determination. |
| 2 | 21855631 | The entire differentiation process is carried out in serum-free chemically-defined media (CDM) and results in reliable and robust induction of pancreatic endoderm cells, marked by PDX1, and cell clusters co-expressing markers characteristic of beta cells, including PDX1 and insulin/C-peptide. |
| 3 | 21855631 | Varying the combinations of growth factors, we found that treatment of hESCs with bFGF, Activin A and BMP4 (FAB) together for 3-4days resulted in strong induction of primitive-streak and definitive endoderm-associated genes, including MIXL1, GSC, SOX17 and FOXA2. |
| 4 | 21855631 | Early proliferative foregut endoderm and pancreatic lineage cells marked by PDX1, FOXA2 and SOX9 expression are specified in EBs made from FAB-treated hESCs, but not from Activin A alone treated cells. |
| 5 | 21855631 | Further differentiation occurs after EBs are embedded in Matrigel and cultured in serum-free media containing insulin, transferrin, selenium, FGF7, nicotinamide, islet neogenesis associated peptide (INGAP) and exendin-4, a long acting GLP-1 agonist. 21-28days after embedding, PDX1 gene expression levels are comparable to those of human islets used for transplantation, and many PDX1(+) clusters are formed. |
| 6 | 21855631 | Almost all cells in PDX1(+) clusters co-express FOXA2, HNF1ß, HNF6 and SOX9 proteins, and many cells also express CPA1, NKX6.1 and PTF1a. |