Ignet

Gene Information

Gene symbol: HBA2

Gene name: hemoglobin, alpha 2

HGNC ID: 4824

Related Genes

#	Gene Symbol	Number of hits
1	ACTB	1 hits
2	CASP3	1 hits
3	GATA1	1 hits
4	HBA1	1 hits
5	HBB	1 hits
6	HBD	1 hits
7	HBE1	1 hits
8	HBZ	1 hits
9	KRT124P	1 hits
10	YY1	1 hits

Related Sentences

#	PMID	Sentence
1	1932755	Quantitation, performed by scintillation counting of 32P-dCTP incorporated into specific globin cDNA bands, showed ratios of alpha/beta-globin mRNA greater than 10-fold and greater than fivefold increased in patients with beta 0- and beta (+)-thal, respectively, as well as a relative increase in gamma-globin mRNA levels.
2	1932755	Conversely, patients with alpha-thalassemia showed a decreased ratio of alpha/beta-globin mRNA proportional to the number of alpha-globin genes deleted.
3	1990287	We show that expression in fibroblasts of a single cDNA, encoding the erythroid DNA-binding protein Eryf1 (GF-1, NF-E1), very efficiently activates transcription of a chicken alpha-globin promoter, trans-Activation in these cells occurred when Eryf1 bound to a single site within a minimal globin promoter.
4	2475189	Gene mapping of the zeta-alpha-globin gene cluster was performed in 12 newborns in whom cord blood zeta-globin chains had been determined.
5	6185291	In the reported case the levels for HbA1, measured by the colorimetric thiobarbiturate method, and the difference both between HbA2 (micro-column chromatography) as well as HbF values, corresponded to the blood sugar concentrations.
6	9207479	Hemoglobin A2 (HbA2), which contains delta-globin as its non-alpha-globin, represents a minor fraction of the Hb found in normal adults.
7	9207479	To elucidate the mechanisms responsible for the low-level expression of the delta-globin gene in adult erythroid cells, we first compared promoter sequences and found that the delta-globin gene differs from the beta-globin gene in the absence of an erythroid Krüppel-like factor (EKLF) binding site, the alteration of the CCAAT box to CCAAC, and the presence of a GATA-1 binding site.
8	9293854	Group 2 included patients with beta+/beta+ or beta+/beta0 genotype and one alpha-globin chain deletion and those with a moderate amount of beta-globin chain synthesis (beta++) and normal alpha-globin chain synthesis.
9	10228386	The diagnosis was made by DNA analyses of the nucleotide sequencing of the beta-globin gene for beta-thals and of the alpha-globin gene arrangement for alpha-thals. beta-Thals found in Japanese mainly involve a point mutation, such as-31CapA-->G(in ATA box) and beta 90 codon GAG-->TAG(creation of a stop codon).
10	11167015	Levels of GATA-1/GATA-2 transcription factors modulate expression of embryonic and fetal hemoglobins.
11	11167015	GATA-1 and GATA-2, coexpressed in erythroid cells, are important for expression of erythroid genes.
12	11167015	Conserved GATA sites were found in each of the hypersensitive sites in both beta-and alpha clusters and in proximal regulatory regions of the zeta-, epsilon- and gamma-globin but not the alpha, delta or beta-globin genes.
13	11167015	We then tested the effect of increasing levels of GATA-1 and GATA-2 on the expression of endogenous globin genes in human erythroid cells.
14	11167015	Increasing GATA-1 levels in K562 cells decreased the levels of epsilon-globin mRNA but had no effect on the levels of expression of gamma, zeta or alpha-globin genes.
15	11167015	Increasing GATA-2 levels increased epsilon-globin and gamma-globin transcripts.
16	11167015	Increasing levels of GATA-1 also caused a decrease in the expression of endogenous GATA-2, while increased levels of GATA-2 had no effect on GATA-1 mRNA.
17	11167015	Our results indicate a differential role of GATA-1 and -2 transcription factors on globin transcripts and suggest a correlation between the conservation of GATA sites in the regulatory regions and the ability of endogenous globin genes to respond to GATA transcription factors.
18	11167015	They also suggest that quantitative changes in the levels of GATA-1 or GATA-2 can result in alterations of globin target gene expression and may participate in the ontogenic control of the globin genes.
19	11283524	The number of alpha-globin genes present in the subjects was determined by the intensity of alpha1 and alpha2 bands normalized with that of beta-actin when using densitometry.
20	12038033	The most common beta globin gene defects were C-39 (30.7%); IVS-I nt 110 (20%); IVS-I nt 6 (13.3%); IVS-I nt 1(4%). alpha globin genes were normal in 42 patients, 1 patient had triplicate and cuadriplicate alpha globin genes and 2 patients were not analyzed.
21	22912363	The CAPILLARYS HbA(1c) kit used on the CAPILLARYS 2 Flex Piercing system is designed for separating and quantifying the HbA(1c) fraction of hemoglobin while detecting hemoglobin variants and HbA(2).
22	22912363	The reliability of the system for HbA(2) measurement was also assessed.
23	22912363	Moreover, the technique provides a rapid and reliable separation of HbA(2).
24	22912363	The CAPILLARYS HbA(1c) kit used on the CAPILLARYS 2 Flex Piercing system is designed for separating and quantifying the HbA(1c) fraction of hemoglobin while detecting hemoglobin variants and HbA(2).
25	22912363	The reliability of the system for HbA(2) measurement was also assessed.
26	22912363	Moreover, the technique provides a rapid and reliable separation of HbA(2).
27	22912363	The CAPILLARYS HbA(1c) kit used on the CAPILLARYS 2 Flex Piercing system is designed for separating and quantifying the HbA(1c) fraction of hemoglobin while detecting hemoglobin variants and HbA(2).
28	22912363	The reliability of the system for HbA(2) measurement was also assessed.
29	22912363	Moreover, the technique provides a rapid and reliable separation of HbA(2).
30	23861885	To bridge this gap, we developed an artificially engineered model for human beta thalassemia by knocking down beta-globin gene and protein expression in cultured CD34+ cells obtained from healthy adults.
31	23861885	Beta-globin mRNA was reduced by 90% compared to controls, while alpha-globin mRNA levels were maintained.
32	23861885	During the terminal phases of differentiation (culture days 14-21), beta-KD cells demonstrated increased levels of insoluble alpha-globin, as well as activated caspase-3.
33	23861885	To bridge this gap, we developed an artificially engineered model for human beta thalassemia by knocking down beta-globin gene and protein expression in cultured CD34+ cells obtained from healthy adults.
34	23861885	Beta-globin mRNA was reduced by 90% compared to controls, while alpha-globin mRNA levels were maintained.
35	23861885	During the terminal phases of differentiation (culture days 14-21), beta-KD cells demonstrated increased levels of insoluble alpha-globin, as well as activated caspase-3.