Ignet

Gene Information

Gene symbol: HEXB

Gene name: hexosaminidase B (beta polypeptide)

HGNC ID: 4879

Related Genes

#	Gene Symbol	Number of hits
1	DPP7	1 hits
2	FOS	1 hits
3	HEXA	1 hits
4	INS	1 hits
5	MGEA5	1 hits
6	PTTG1IP	1 hits
7	SP6	1 hits
8	STEAP3	1 hits

Related Sentences

#	PMID	Sentence
1	851488	For example in serum of patients with juvenile diabetes mellitus there is a characteristic elevation of hexosaminidase B and less consistently, of hexosaminidase A.
2	2971039	The synthesis and dimerization of beta-chains during the formation of catalytically active beta-hexosaminidase B were studied in a cell-free system. beta-chain mRNA, transcribed from the cloned cDNA with SP6 polymerase, was translated in a rabbit reticulocyte protein-synthesizing system in the presence of dog pancreas microsomal membranes and oxidized glutathione.
3	6094290	Inhibition of insulin degrading activity (IDA) during chloroquine therapy was associated with reductions in the leukocyte lysosomal enzymes alpha-galactosidase and hexosaminidase-A but not hexosaminidase-B and beta-glucuronidase.
4	7550345	Through disruption of the Hexa and Hexb genes in embryonic stem cells, we have established mouse models corresponding to each disease.
5	7959736	Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb.
6	7959736	Two genes, HEXA and HEXB, encode the alpha- and beta-subunits, respectively, of human beta-hexosaminidase.
7	7959736	In the mouse, the corresponding genes are termed Hexa and Hexb.
8	7959736	Mutations in the HEXA or HEXB gene resulting in a beta-hexosaminidase deficiency cause Tay-Sachs or Sandhoff disease, respectively.
9	7959736	Protein sequences derived from the cloned Hexa and Hexb cDNAs were 55% identical to each other and were also very similar to the cognate human sequences: 84% sequence identity with human HEXA and 75% with HEXB.
10	7959736	The Hexa and Hexb genes were 25 and 22 kb in length, respectively.
11	7959736	Several putative promoter elements were present, including Sp1, AP2, CAAT, and TATA motifs.
12	7959736	Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb.
13	7959736	Two genes, HEXA and HEXB, encode the alpha- and beta-subunits, respectively, of human beta-hexosaminidase.
14	7959736	In the mouse, the corresponding genes are termed Hexa and Hexb.
15	7959736	Mutations in the HEXA or HEXB gene resulting in a beta-hexosaminidase deficiency cause Tay-Sachs or Sandhoff disease, respectively.
16	7959736	Protein sequences derived from the cloned Hexa and Hexb cDNAs were 55% identical to each other and were also very similar to the cognate human sequences: 84% sequence identity with human HEXA and 75% with HEXB.
17	7959736	The Hexa and Hexb genes were 25 and 22 kb in length, respectively.
18	7959736	Several putative promoter elements were present, including Sp1, AP2, CAAT, and TATA motifs.
19	7959736	Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb.
20	7959736	Two genes, HEXA and HEXB, encode the alpha- and beta-subunits, respectively, of human beta-hexosaminidase.
21	7959736	In the mouse, the corresponding genes are termed Hexa and Hexb.
22	7959736	Mutations in the HEXA or HEXB gene resulting in a beta-hexosaminidase deficiency cause Tay-Sachs or Sandhoff disease, respectively.
23	7959736	Protein sequences derived from the cloned Hexa and Hexb cDNAs were 55% identical to each other and were also very similar to the cognate human sequences: 84% sequence identity with human HEXA and 75% with HEXB.
24	7959736	The Hexa and Hexb genes were 25 and 22 kb in length, respectively.
25	7959736	Several putative promoter elements were present, including Sp1, AP2, CAAT, and TATA motifs.
26	7959736	Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb.
27	7959736	Two genes, HEXA and HEXB, encode the alpha- and beta-subunits, respectively, of human beta-hexosaminidase.
28	7959736	In the mouse, the corresponding genes are termed Hexa and Hexb.
29	7959736	Mutations in the HEXA or HEXB gene resulting in a beta-hexosaminidase deficiency cause Tay-Sachs or Sandhoff disease, respectively.
30	7959736	Protein sequences derived from the cloned Hexa and Hexb cDNAs were 55% identical to each other and were also very similar to the cognate human sequences: 84% sequence identity with human HEXA and 75% with HEXB.
31	7959736	The Hexa and Hexb genes were 25 and 22 kb in length, respectively.
32	7959736	Several putative promoter elements were present, including Sp1, AP2, CAAT, and TATA motifs.
33	7959736	Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb.
34	7959736	Two genes, HEXA and HEXB, encode the alpha- and beta-subunits, respectively, of human beta-hexosaminidase.
35	7959736	In the mouse, the corresponding genes are termed Hexa and Hexb.
36	7959736	Mutations in the HEXA or HEXB gene resulting in a beta-hexosaminidase deficiency cause Tay-Sachs or Sandhoff disease, respectively.
37	7959736	Protein sequences derived from the cloned Hexa and Hexb cDNAs were 55% identical to each other and were also very similar to the cognate human sequences: 84% sequence identity with human HEXA and 75% with HEXB.
38	7959736	The Hexa and Hexb genes were 25 and 22 kb in length, respectively.
39	7959736	Several putative promoter elements were present, including Sp1, AP2, CAAT, and TATA motifs.
40	7959736	Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb.
41	7959736	Two genes, HEXA and HEXB, encode the alpha- and beta-subunits, respectively, of human beta-hexosaminidase.
42	7959736	In the mouse, the corresponding genes are termed Hexa and Hexb.
43	7959736	Mutations in the HEXA or HEXB gene resulting in a beta-hexosaminidase deficiency cause Tay-Sachs or Sandhoff disease, respectively.
44	7959736	Protein sequences derived from the cloned Hexa and Hexb cDNAs were 55% identical to each other and were also very similar to the cognate human sequences: 84% sequence identity with human HEXA and 75% with HEXB.
45	7959736	The Hexa and Hexb genes were 25 and 22 kb in length, respectively.
46	7959736	Several putative promoter elements were present, including Sp1, AP2, CAAT, and TATA motifs.
47	8634145	Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.
48	8634145	Human lysosomal beta-hexosaminidases are encoded by two genes, HEXA and HEXB, specifying an alpha- and a beta-subunit, respectively.
49	8634145	The subunits dimerize to form beta-hexosaminidase A (alpha beta), beta-hexosaminidase B (beta beta), and beta-hexosaminidase S (alpha alpha).
50	8634145	Mutations in either the HEXA gene or HEXB gene lead to an accumulation of GM2 ganglioside in neurons, resulting in the severe neurodegenerative disorders termed the GM2 gangliosidoses.
51	8634145	This area contained two potential estrogen response element half-sites as well as potential binding sites for transcription factors NF-E1 and AP-2.
52	8634145	By performing scanning mutagenesis on a 60-bp region within the 150-bp HEXB construct, we defined an essential promoter element of 12 bp that contained two potential AP-1 sites.
53	8634145	The mouse Hexa and Hexb 5'-flanking sequences were found to contain regions similar in sequence, location, and activity to the essential promoter elements defined in the cognate human genes.
54	8634145	No sequence similarity was found, however, between 5'-flanking regions of the HEXA and HEXB genes.
55	8634145	These essential promoter elements represent potential sites for HEXA and HEXB mutations that could alter enzyme expression in Tay-Sachs and Sandhoff diseases, respectively.
56	8634145	Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.
57	8634145	Human lysosomal beta-hexosaminidases are encoded by two genes, HEXA and HEXB, specifying an alpha- and a beta-subunit, respectively.
58	8634145	The subunits dimerize to form beta-hexosaminidase A (alpha beta), beta-hexosaminidase B (beta beta), and beta-hexosaminidase S (alpha alpha).
59	8634145	Mutations in either the HEXA gene or HEXB gene lead to an accumulation of GM2 ganglioside in neurons, resulting in the severe neurodegenerative disorders termed the GM2 gangliosidoses.
60	8634145	This area contained two potential estrogen response element half-sites as well as potential binding sites for transcription factors NF-E1 and AP-2.
61	8634145	By performing scanning mutagenesis on a 60-bp region within the 150-bp HEXB construct, we defined an essential promoter element of 12 bp that contained two potential AP-1 sites.
62	8634145	The mouse Hexa and Hexb 5'-flanking sequences were found to contain regions similar in sequence, location, and activity to the essential promoter elements defined in the cognate human genes.
63	8634145	No sequence similarity was found, however, between 5'-flanking regions of the HEXA and HEXB genes.
64	8634145	These essential promoter elements represent potential sites for HEXA and HEXB mutations that could alter enzyme expression in Tay-Sachs and Sandhoff diseases, respectively.
65	8634145	Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.
66	8634145	Human lysosomal beta-hexosaminidases are encoded by two genes, HEXA and HEXB, specifying an alpha- and a beta-subunit, respectively.
67	8634145	The subunits dimerize to form beta-hexosaminidase A (alpha beta), beta-hexosaminidase B (beta beta), and beta-hexosaminidase S (alpha alpha).
68	8634145	Mutations in either the HEXA gene or HEXB gene lead to an accumulation of GM2 ganglioside in neurons, resulting in the severe neurodegenerative disorders termed the GM2 gangliosidoses.
69	8634145	This area contained two potential estrogen response element half-sites as well as potential binding sites for transcription factors NF-E1 and AP-2.
70	8634145	By performing scanning mutagenesis on a 60-bp region within the 150-bp HEXB construct, we defined an essential promoter element of 12 bp that contained two potential AP-1 sites.
71	8634145	The mouse Hexa and Hexb 5'-flanking sequences were found to contain regions similar in sequence, location, and activity to the essential promoter elements defined in the cognate human genes.
72	8634145	No sequence similarity was found, however, between 5'-flanking regions of the HEXA and HEXB genes.
73	8634145	These essential promoter elements represent potential sites for HEXA and HEXB mutations that could alter enzyme expression in Tay-Sachs and Sandhoff diseases, respectively.
74	8634145	Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.
75	8634145	Human lysosomal beta-hexosaminidases are encoded by two genes, HEXA and HEXB, specifying an alpha- and a beta-subunit, respectively.
76	8634145	The subunits dimerize to form beta-hexosaminidase A (alpha beta), beta-hexosaminidase B (beta beta), and beta-hexosaminidase S (alpha alpha).
77	8634145	Mutations in either the HEXA gene or HEXB gene lead to an accumulation of GM2 ganglioside in neurons, resulting in the severe neurodegenerative disorders termed the GM2 gangliosidoses.
78	8634145	This area contained two potential estrogen response element half-sites as well as potential binding sites for transcription factors NF-E1 and AP-2.
79	8634145	By performing scanning mutagenesis on a 60-bp region within the 150-bp HEXB construct, we defined an essential promoter element of 12 bp that contained two potential AP-1 sites.
80	8634145	The mouse Hexa and Hexb 5'-flanking sequences were found to contain regions similar in sequence, location, and activity to the essential promoter elements defined in the cognate human genes.
81	8634145	No sequence similarity was found, however, between 5'-flanking regions of the HEXA and HEXB genes.
82	8634145	These essential promoter elements represent potential sites for HEXA and HEXB mutations that could alter enzyme expression in Tay-Sachs and Sandhoff diseases, respectively.
83	8634145	Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.
84	8634145	Human lysosomal beta-hexosaminidases are encoded by two genes, HEXA and HEXB, specifying an alpha- and a beta-subunit, respectively.
85	8634145	The subunits dimerize to form beta-hexosaminidase A (alpha beta), beta-hexosaminidase B (beta beta), and beta-hexosaminidase S (alpha alpha).
86	8634145	Mutations in either the HEXA gene or HEXB gene lead to an accumulation of GM2 ganglioside in neurons, resulting in the severe neurodegenerative disorders termed the GM2 gangliosidoses.
87	8634145	This area contained two potential estrogen response element half-sites as well as potential binding sites for transcription factors NF-E1 and AP-2.
88	8634145	By performing scanning mutagenesis on a 60-bp region within the 150-bp HEXB construct, we defined an essential promoter element of 12 bp that contained two potential AP-1 sites.
89	8634145	The mouse Hexa and Hexb 5'-flanking sequences were found to contain regions similar in sequence, location, and activity to the essential promoter elements defined in the cognate human genes.
90	8634145	No sequence similarity was found, however, between 5'-flanking regions of the HEXA and HEXB genes.
91	8634145	These essential promoter elements represent potential sites for HEXA and HEXB mutations that could alter enzyme expression in Tay-Sachs and Sandhoff diseases, respectively.
92	8634145	Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.
93	8634145	Human lysosomal beta-hexosaminidases are encoded by two genes, HEXA and HEXB, specifying an alpha- and a beta-subunit, respectively.
94	8634145	The subunits dimerize to form beta-hexosaminidase A (alpha beta), beta-hexosaminidase B (beta beta), and beta-hexosaminidase S (alpha alpha).
95	8634145	Mutations in either the HEXA gene or HEXB gene lead to an accumulation of GM2 ganglioside in neurons, resulting in the severe neurodegenerative disorders termed the GM2 gangliosidoses.
96	8634145	This area contained two potential estrogen response element half-sites as well as potential binding sites for transcription factors NF-E1 and AP-2.
97	8634145	By performing scanning mutagenesis on a 60-bp region within the 150-bp HEXB construct, we defined an essential promoter element of 12 bp that contained two potential AP-1 sites.
98	8634145	The mouse Hexa and Hexb 5'-flanking sequences were found to contain regions similar in sequence, location, and activity to the essential promoter elements defined in the cognate human genes.
99	8634145	No sequence similarity was found, however, between 5'-flanking regions of the HEXA and HEXB genes.
100	8634145	These essential promoter elements represent potential sites for HEXA and HEXB mutations that could alter enzyme expression in Tay-Sachs and Sandhoff diseases, respectively.
101	8634145	Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.
102	8634145	Human lysosomal beta-hexosaminidases are encoded by two genes, HEXA and HEXB, specifying an alpha- and a beta-subunit, respectively.
103	8634145	The subunits dimerize to form beta-hexosaminidase A (alpha beta), beta-hexosaminidase B (beta beta), and beta-hexosaminidase S (alpha alpha).
104	8634145	Mutations in either the HEXA gene or HEXB gene lead to an accumulation of GM2 ganglioside in neurons, resulting in the severe neurodegenerative disorders termed the GM2 gangliosidoses.
105	8634145	This area contained two potential estrogen response element half-sites as well as potential binding sites for transcription factors NF-E1 and AP-2.
106	8634145	By performing scanning mutagenesis on a 60-bp region within the 150-bp HEXB construct, we defined an essential promoter element of 12 bp that contained two potential AP-1 sites.
107	8634145	The mouse Hexa and Hexb 5'-flanking sequences were found to contain regions similar in sequence, location, and activity to the essential promoter elements defined in the cognate human genes.
108	8634145	No sequence similarity was found, however, between 5'-flanking regions of the HEXA and HEXB genes.
109	8634145	These essential promoter elements represent potential sites for HEXA and HEXB mutations that could alter enzyme expression in Tay-Sachs and Sandhoff diseases, respectively.
110	8634145	Promoters for the human beta-hexosaminidase genes, HEXA and HEXB.
111	8634145	Human lysosomal beta-hexosaminidases are encoded by two genes, HEXA and HEXB, specifying an alpha- and a beta-subunit, respectively.
112	8634145	The subunits dimerize to form beta-hexosaminidase A (alpha beta), beta-hexosaminidase B (beta beta), and beta-hexosaminidase S (alpha alpha).
113	8634145	Mutations in either the HEXA gene or HEXB gene lead to an accumulation of GM2 ganglioside in neurons, resulting in the severe neurodegenerative disorders termed the GM2 gangliosidoses.
114	8634145	This area contained two potential estrogen response element half-sites as well as potential binding sites for transcription factors NF-E1 and AP-2.
115	8634145	By performing scanning mutagenesis on a 60-bp region within the 150-bp HEXB construct, we defined an essential promoter element of 12 bp that contained two potential AP-1 sites.
116	8634145	The mouse Hexa and Hexb 5'-flanking sequences were found to contain regions similar in sequence, location, and activity to the essential promoter elements defined in the cognate human genes.
117	8634145	No sequence similarity was found, however, between 5'-flanking regions of the HEXA and HEXB genes.
118	8634145	These essential promoter elements represent potential sites for HEXA and HEXB mutations that could alter enzyme expression in Tay-Sachs and Sandhoff diseases, respectively.
119	8896570	The GM2 gangliosidoses, Tay-Sachs and Sandhoff diseases, are caused by mutations in the HEXA (alpha-subunit) and HEXB (beta-subunit) genes, respectively.
120	8896570	Each gene encodes a subunit for the heterodimeric lysosomal enzyme, beta-hexosaminidase A (alpha beta), as well as for the homodimers beta-hexosaminidase B (beta beta) and S (alpha alpha).
121	8896570	In this study, we have produced mice that have both Hexa and Hexb genes disrupted through interbreeding Tay-Sachs (Hexa-/-) and Sandhoff (Hexb-/-) disease model mice.
122	8896570	The GM2 gangliosidoses, Tay-Sachs and Sandhoff diseases, are caused by mutations in the HEXA (alpha-subunit) and HEXB (beta-subunit) genes, respectively.
123	8896570	Each gene encodes a subunit for the heterodimeric lysosomal enzyme, beta-hexosaminidase A (alpha beta), as well as for the homodimers beta-hexosaminidase B (beta beta) and S (alpha alpha).
124	8896570	In this study, we have produced mice that have both Hexa and Hexb genes disrupted through interbreeding Tay-Sachs (Hexa-/-) and Sandhoff (Hexb-/-) disease model mice.
125	8896570	The GM2 gangliosidoses, Tay-Sachs and Sandhoff diseases, are caused by mutations in the HEXA (alpha-subunit) and HEXB (beta-subunit) genes, respectively.
126	8896570	Each gene encodes a subunit for the heterodimeric lysosomal enzyme, beta-hexosaminidase A (alpha beta), as well as for the homodimers beta-hexosaminidase B (beta beta) and S (alpha alpha).
127	8896570	In this study, we have produced mice that have both Hexa and Hexb genes disrupted through interbreeding Tay-Sachs (Hexa-/-) and Sandhoff (Hexb-/-) disease model mice.
128	9223328	Tay-Sachs and Sandhoff diseases are caused by mutations in the genes (HEXA and HEXB) encoding the subunits of beta-hexosaminidase A.
129	9223328	We previously have described mouse models of Tay-Sachs (Hexa -/-) and Sandhoff (Hexb -/-) diseases with vastly different clinical phenotypes.
130	9223328	The Hexa -/- mice were asymptomatic whereas the Hexb -/- mice were severely affected.
131	9223328	Tay-Sachs and Sandhoff diseases are caused by mutations in the genes (HEXA and HEXB) encoding the subunits of beta-hexosaminidase A.
132	9223328	We previously have described mouse models of Tay-Sachs (Hexa -/-) and Sandhoff (Hexb -/-) diseases with vastly different clinical phenotypes.
133	9223328	The Hexa -/- mice were asymptomatic whereas the Hexb -/- mice were severely affected.
134	9223328	Tay-Sachs and Sandhoff diseases are caused by mutations in the genes (HEXA and HEXB) encoding the subunits of beta-hexosaminidase A.
135	9223328	We previously have described mouse models of Tay-Sachs (Hexa -/-) and Sandhoff (Hexb -/-) diseases with vastly different clinical phenotypes.
136	9223328	The Hexa -/- mice were asymptomatic whereas the Hexb -/- mice were severely affected.
137	16568991	A novel analogue of PUGNAc, a potent O-GlcNAcase inhibitor, was synthesized and analyzed as an inhibitor of O-GlcNAcase, hexosaminidase A, and hexosaminidase B.
138	16568991	While PUGNAc does not demonstrate selective inhibition of these related enzymes, the extension of the acetyl moiety to the longer butyl chain provided a compound with depressed inhibition of O-GlcNAcase and no observed inhibition of either hexosaminidase A or hexosaminidase B.
139	16568991	Gratifyingly, this altered small molecule was demonstrated to be a potent substrate for O-GlcNAcase while possessing no activity at hexosaminidase A.
140	16568991	This reagent provides, for the first time, a means for monitoring O-GlcNAcase activity independent of the related enzymes hexosaminidase A and hexosaminidase B.
141	16568991	A novel analogue of PUGNAc, a potent O-GlcNAcase inhibitor, was synthesized and analyzed as an inhibitor of O-GlcNAcase, hexosaminidase A, and hexosaminidase B.
142	16568991	While PUGNAc does not demonstrate selective inhibition of these related enzymes, the extension of the acetyl moiety to the longer butyl chain provided a compound with depressed inhibition of O-GlcNAcase and no observed inhibition of either hexosaminidase A or hexosaminidase B.
143	16568991	Gratifyingly, this altered small molecule was demonstrated to be a potent substrate for O-GlcNAcase while possessing no activity at hexosaminidase A.
144	16568991	This reagent provides, for the first time, a means for monitoring O-GlcNAcase activity independent of the related enzymes hexosaminidase A and hexosaminidase B.
145	16568991	A novel analogue of PUGNAc, a potent O-GlcNAcase inhibitor, was synthesized and analyzed as an inhibitor of O-GlcNAcase, hexosaminidase A, and hexosaminidase B.
146	16568991	While PUGNAc does not demonstrate selective inhibition of these related enzymes, the extension of the acetyl moiety to the longer butyl chain provided a compound with depressed inhibition of O-GlcNAcase and no observed inhibition of either hexosaminidase A or hexosaminidase B.
147	16568991	Gratifyingly, this altered small molecule was demonstrated to be a potent substrate for O-GlcNAcase while possessing no activity at hexosaminidase A.
148	16568991	This reagent provides, for the first time, a means for monitoring O-GlcNAcase activity independent of the related enzymes hexosaminidase A and hexosaminidase B.
149	21678470	In addition to previously reported differentially expressed molecules, more than 20 altered proteins previously unknown to be involved with adipogenic process were firstly revealed (e.g., HEXB, DPP7, PTTG1IP, PRDX5, EPDR1, SPNB2, STEAP3, TPP1, etc.).