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Gene Information
Gene symbol: HEY2
Gene name: hairy/enhancer-of-split related with YRPW motif 2
HGNC ID: 4881
Synonyms: bHLHb32, HERP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HES1 | 1 hits |
| 2 | HEY1 | 1 hits |
| 3 | MYC | 1 hits |
| 4 | NOTCH1 | 1 hits |
| 5 | NOTCH2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17003479 | We demonstrate that under these experimental conditions the exocrine acinar cells lose their differentiated characteristics: expression of the acinar transcription factors p48/Ptf1alpha and Mist1 is decreased or lost, whereas expression of the embryonic transcription factor Pdx1 is increased. |
| 2 | 17003479 | The receptors Notch1 and Notch2, members of the DSL family of Notch ligands, and the target genes in the Notch-signaling pathway Hes1, Hey1, and Hey2 become strongly up-regulated. |
| 3 | 17003479 | This effect seems to be Hes1-independent and mainly coincides with decreased Hey1 and Hey2 mRNA expression. |
| 4 | 17003479 | We demonstrate that under these experimental conditions the exocrine acinar cells lose their differentiated characteristics: expression of the acinar transcription factors p48/Ptf1alpha and Mist1 is decreased or lost, whereas expression of the embryonic transcription factor Pdx1 is increased. |
| 5 | 17003479 | The receptors Notch1 and Notch2, members of the DSL family of Notch ligands, and the target genes in the Notch-signaling pathway Hes1, Hey1, and Hey2 become strongly up-regulated. |
| 6 | 17003479 | This effect seems to be Hes1-independent and mainly coincides with decreased Hey1 and Hey2 mRNA expression. |
| 7 | 21494254 | With confirmation using RNA and protein analyses, GSI-I blocked nuclear accumulation of cleaved Notch1 and Notch2, and inhibited Notch targets Hey2 and Myc. |