Ignet

Gene Information

Gene symbol: HLA-DMA

Gene name: major histocompatibility complex, class II, DM alpha

HGNC ID: 4934

Synonyms: D6S222E, RING6

Related Genes

#	Gene Symbol	Number of hits
1	AHSA1	1 hits
2	HLA-A	1 hits
3	HLA-DMB	1 hits
4	IDDM2	1 hits
5	MMD	1 hits
6	NFE2L2	1 hits
7	NFKB1	1 hits
8	NXF1	1 hits
9	PSMB9	1 hits
10	STAT1	1 hits
11	TNF	1 hits

Related Sentences

#	PMID	Sentence
1	9536430	Thus, a subset of both T cell and mAb allodeterminants are influenced by a DM-dependent interaction of MHC molecules with peptides, while the formation of DM-independent allodeterminants may represent direct MHC epitope recognition by the T cell receptor or an alternative peptide loading mechanism distinct from the HLA-DM pathways.
2	10051633	In addition to causing abnormal MHC expression, the ds nucleic acids increase the expression of genes necessary for antigen processing and presentation: proteasome proteins (e.g., LMP2), transporters of antigen peptides; invariant chain, HLA-DM, and the costimulatory molecule B7.1.
3	10051633	The ds nucleic acids also induce or activate Stat1, Stat3, mitogen-activated protein kinase, NF-kappaB, the class II transactivator, RFX5, and the IFN regulatory factor 1 differently from gammaIFN.
4	10427471	Implication of HLA-DMA alleles in corsican IDDM.
5	10427471	The study of the DMA gene could therefore be an additional tool for early IDDM diagnosis in the Corsican population.
6	10427471	Implication of HLA-DMA alleles in corsican IDDM.
7	10427471	The study of the DMA gene could therefore be an additional tool for early IDDM diagnosis in the Corsican population.
8	10519369	HLA-DMA and HLA-DMB alleles in German patients with type 1 diabetes mellitus.
9	10519369	The HLA-DMA and HLA-DMB genes are located in the HLA-D region between DQ and DP.
10	10519369	HLA-DMA and HLA-DMB alleles in German patients with type 1 diabetes mellitus.
11	10519369	The HLA-DMA and HLA-DMB genes are located in the HLA-D region between DQ and DP.
12	11129119	These include increased expression of proteasome processing proteins (LMP2), transporters of antigen peptides (TAP), invariant chain (Ii), HLA-DM, and the co-stimulatory molecule, B7, as well as STAT and NF-kappaB activation.
13	11129119	A critical factor in these changes is the loss of normal negative regulation of MHC class I, class II, and thyrotropin receptor (TSHR) gene expression, which is necessary to maintain self-tolerance during the normal changes in gene expression involved in hormonally-increased growth and function of the cell.
14	11129119	Self-tolerance to the TSHR is maintained in normals because there is a population of CD8- cells which normally suppresses a population of CD4+ cells that can interact with the TSHR if thyrocytes become APCs.
15	21510113	Proposed biological mechanisms in experimental animals included up regulation of inflammatory signals like cytokines and TNF-alpha, oxidative stress, hypomethylation, decreased DNA repair and apoptosis, cell proliferation, angiogenesis, activation of several enzymes like methyl transferase which converts inorganic arsenic to MMA and DMA, and GSH in in-vivo and in-vitro in experimental rat liver slices.
16	21775680	HLA-DM (DM) catalyzes CLIP release, stabilizes MHC class II molecules, and edits the peptide repertoire presented by class II.
17	21775680	The effects of mutations were investigated by measuring the peptide dissociation and exchange rate in vitro, CLIP and DQ2 expression on the cell surface, and the presentation of α-II-gliadin epitope (residues 62-70) to murine, DQ2-restricted T cell hybridomas.
18	23434766	We found that DMA inhibited inflammatory cytokine production via upregulation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and alleviated oxidative stress through attenuation of p47phox translocation to the membrane of S100b-treated THP-1 monocytes.
19	23434766	We found that DMA activated Nrf2 mediated by the p38 kinase pathway in THP-1 monocytes.
20	23434766	The in vivo verification of anti-inflammation in peripheral blood mononuclear cells by DMA treatment was confirmed by tumor necrosis factor-α and interleukin-1β measurements.