Ignet

Gene Information

Gene symbol: HLA-DRB5

Gene name: major histocompatibility complex, class II, DR beta 5

HGNC ID: 4953

Related Genes

#	Gene Symbol	Number of hits
1	CD4	1 hits
2	CTLA4	1 hits
3	GAD2	1 hits
4	HLA-B	1 hits
5	HLA-DRB1	1 hits
6	HLA-DRB3	1 hits
7	HLA-DRB4	1 hits
8	HSPA1A	1 hits
9	IDDM2	1 hits
10	INS	1 hits
11	PTPN22	1 hits

Related Sentences

#	PMID	Sentence
1	7821177	Human leukocyte antigen class II polymorphisms and genetic susceptibility of IDDM in Egyptian children.
2	9237801	Polymorphism of the genes coding for the human histocompatibility leukocyte antigen class II DR and DQ molecules makes the single largest genetic contribution to the risk of developing insulin-dependent diabetes mellitus (IDDM) and can be associated with highly elevated as well as decreased disease frequency.
3	9237801	We have generated T cell lines (TCL) with specificity for the IDDM autoantigen 65 kDa glutamic acid decarboxylase (GAD65) from lymphocytes of two patients carrying HLA class II alleles associated with distinct risk of IDDM (DRB1*0101/0401 and 1302/1501).
4	9237801	This epitope overlaps with a central GAD peptide binding to the high risk allele DQB10302 and containing a Coxsackie P2C-identical mimicry sequence, raising the possibility of competition of DRB50101 and DQB1*0302 for binding of a central GAD65 fragment.
5	9645372	Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease with a predominantly non-hereditary etiology that results in a destruction of pancreatic beta cells by autoaggressive T lymphocytes.
6	9645372	We determined sequential epitope motifs to search for mimicry peptides stimulating T cell lines specific for two epitopes derived from the IDDM autoantigen 65-kDa glutamic acid decarboxylase (GAD65).
7	9645372	These were GAD65 (88-99), presented by HLA-DRB10101, and GAD65 (248-257), presented by HLA-DRB50101.
8	9645372	Our results demonstrate that mono- and polyclonal GAD65-specific T cells from IDDM patients can be stimulated by viral and bacterial peptides with little apparent sequence homology with autoantigenic epitopes.
9	10404800	Predictive value of human leukocyte antigen class II typing for the development of islet autoantibodies and insulin-dependent diabetes postpartum in women with gestational diabetes.
10	10404800	Gestational diabetes mellitus (GDM) is a risk factor for the development of insulin-dependent diabetes mellitus (IDDM) and noninsulin-dependent diabetes mellitus postpartum.
11	10404800	To evaluate whether there is any association of human leukocyte antigen (HLA) class II alleles (DR and DQ) with GDM and the postpartum development of IDDM, we analyzed 184 women with GDM from Germany for HLA class II alleles, islet autoantibodies [islet cell autoantibodies (ICA), glutamic acid decarboxylase autoantibodies (GADA), and protein tyrosine phosphatase IA-2 autoantibodies (IA-2A), and the postpartum development of diabetes.
12	10404800	Twenty-five (59.5%) islet antibody-positive women and 17 (74%) women who developed IDDM postpartum had a DR3- or DR4-containing genotype.
13	10404800	The cumulative risk to develop IDDM within 2 yr postpartum in GDM women with either DR3 or DR4 was 22% compared to 7% in women without those alleles (P = 0.02) and rose to 50% in the DR3- or DR4-positive women who had required insulin during pregnancy (P = 0.006).
14	10404800	Combining the determination of susceptible HLA alleles (DR3, DR4) with islet autoantibody measurement increased the sensitivity of identifying GDM women developing postpartum IDDM to 92%, but did not improve risk assessment above that achieved using GADA measurement alone, which was the strongest predictor of IDDM.
15	15643010	Susceptible and protective human leukocyte antigen class II alleles and haplotypes in bahraini type 2 (non-insulin-dependent) diabetes mellitus patients.
16	17668636	The difference between results from this study and that of Caucasians may be due to population differences in genetic polymorphism or to linkage disequilibrium of HSP70-1 with human leukocyte antigen class-II alleles associated with type-1 diabetes susceptibility genes.
17	18776148	At least three genes have been confirmed as major joint susceptibility genes for T1D and AITD: human leukocyte antigen class II, cytotoxic T-lymphocyte antigen 4 (CTLA-4), and protein tyrosine phosphatase non-receptor type 22.
18	19743458	That is because their primary genetic associations are mostly with certain human leukocyte antigen class II alleles, whose gene products present antigens to CD4(+) T cells.
19	21497933	Effect of human leukocyte antigen class II genes on insulin deficiency in slow-onset type 1 diabetes in the Japanese population.
20	23462545	The primary associations of the HLA class II genes, HLA-DRB1 and HLA-DQB1, and the class I genes, HLA-A and HLA-B, with type 1 diabetes (T1D) are well established.
21	23462545	However, the role of polymorphism at the HLA-DRB3, HLA-DRB4, and HLA-DRB5 loci remains unclear.
22	23462545	Analysis of T1D-associated alleles at other HLA loci (HLA-A, HLA-B, and HLA-DPB1) on DRB103:01 haplotypes suggests that DRB302:02 on the DRB1*03:01 haplotype can contribute to T1D risk.