Ignet

Gene Information

Gene symbol: HMBS

Gene name: hydroxymethylbilane synthase

HGNC ID: 4982

Related Genes

#	Gene Symbol	Number of hits
1	ALAD	1 hits
2	B2M	1 hits
3	GAPDH	1 hits
4	HPRT1	1 hits
5	POR	1 hits
6	PPARA	1 hits
7	RPS27A	1 hits
8	SDHA	1 hits
9	TBP	1 hits
10	TST	1 hits
11	UBB	1 hits

Related Sentences

#	PMID	Sentence
1	7565048	In previous studies, it has been demonstrated that both d delta d-aminolevulic acid dehydratase (ALA-D) and porphobilinogen deaminase (PBG-D), enzymes of the heme pathway, are inhibited by high concentrations of glucose in vitro in crude preparations of erythrocytes.
2	7565048	The activities of erythrocytic ALA-D and PBG-D were measured.
3	7565048	ALA-D and PBG-D activities were diminished in diabetic patients (40% and 20% respectively), while rhodanese was only slightly increased (Fig. 1).
4	7565048	ALA-D activity was subnormal in a 92% of the complete diabetic population, while PBG-D activity was less than normal in a 79% of the same population.
5	7565048	In previous studies, it has been demonstrated that both d delta d-aminolevulic acid dehydratase (ALA-D) and porphobilinogen deaminase (PBG-D), enzymes of the heme pathway, are inhibited by high concentrations of glucose in vitro in crude preparations of erythrocytes.
6	7565048	The activities of erythrocytic ALA-D and PBG-D were measured.
7	7565048	ALA-D and PBG-D activities were diminished in diabetic patients (40% and 20% respectively), while rhodanese was only slightly increased (Fig. 1).
8	7565048	ALA-D activity was subnormal in a 92% of the complete diabetic population, while PBG-D activity was less than normal in a 79% of the same population.
9	7565048	In previous studies, it has been demonstrated that both d delta d-aminolevulic acid dehydratase (ALA-D) and porphobilinogen deaminase (PBG-D), enzymes of the heme pathway, are inhibited by high concentrations of glucose in vitro in crude preparations of erythrocytes.
10	7565048	The activities of erythrocytic ALA-D and PBG-D were measured.
11	7565048	ALA-D and PBG-D activities were diminished in diabetic patients (40% and 20% respectively), while rhodanese was only slightly increased (Fig. 1).
12	7565048	ALA-D activity was subnormal in a 92% of the complete diabetic population, while PBG-D activity was less than normal in a 79% of the same population.
13	7565048	In previous studies, it has been demonstrated that both d delta d-aminolevulic acid dehydratase (ALA-D) and porphobilinogen deaminase (PBG-D), enzymes of the heme pathway, are inhibited by high concentrations of glucose in vitro in crude preparations of erythrocytes.
14	7565048	The activities of erythrocytic ALA-D and PBG-D were measured.
15	7565048	ALA-D and PBG-D activities were diminished in diabetic patients (40% and 20% respectively), while rhodanese was only slightly increased (Fig. 1).
16	7565048	ALA-D activity was subnormal in a 92% of the complete diabetic population, while PBG-D activity was less than normal in a 79% of the same population.
17	9287058	Animals were exposed to one of three protocols distinguished by the site of glucose infusion: POR(UPS), POR(ADJ), or peripheral (PER).
18	9287058	By design, hepatic glucose was significantly elevated during POR(UPS) and POR(ADJ) versus PER (4.3 +/- 0.1 vs. 2.4 +/- 0.1 mmol/l, respectively; P < 0.05).
19	9287058	When portohepatic normoglycemia was maintained during POR(UPS), a 67% suppression in the epinephrine response versus that during PER was observed (P < 0.001).
20	9287058	While both POR(UPS) and POR(ADJ) yielded elevated liver glycemia in the face of systemic hypoglycemia, only POR(UPS) yielded an elevated portal vein glucose concentration.
21	9287058	That only POR(UPS) resulted in a significant suppression of the sympathoadrenal response is consistent with the localization of the glucosensors to the portal vein.
22	9287058	Animals were exposed to one of three protocols distinguished by the site of glucose infusion: POR(UPS), POR(ADJ), or peripheral (PER).
23	9287058	By design, hepatic glucose was significantly elevated during POR(UPS) and POR(ADJ) versus PER (4.3 +/- 0.1 vs. 2.4 +/- 0.1 mmol/l, respectively; P < 0.05).
24	9287058	When portohepatic normoglycemia was maintained during POR(UPS), a 67% suppression in the epinephrine response versus that during PER was observed (P < 0.001).
25	9287058	While both POR(UPS) and POR(ADJ) yielded elevated liver glycemia in the face of systemic hypoglycemia, only POR(UPS) yielded an elevated portal vein glucose concentration.
26	9287058	That only POR(UPS) resulted in a significant suppression of the sympathoadrenal response is consistent with the localization of the glucosensors to the portal vein.
27	9287058	Animals were exposed to one of three protocols distinguished by the site of glucose infusion: POR(UPS), POR(ADJ), or peripheral (PER).
28	9287058	By design, hepatic glucose was significantly elevated during POR(UPS) and POR(ADJ) versus PER (4.3 +/- 0.1 vs. 2.4 +/- 0.1 mmol/l, respectively; P < 0.05).
29	9287058	When portohepatic normoglycemia was maintained during POR(UPS), a 67% suppression in the epinephrine response versus that during PER was observed (P < 0.001).
30	9287058	While both POR(UPS) and POR(ADJ) yielded elevated liver glycemia in the face of systemic hypoglycemia, only POR(UPS) yielded an elevated portal vein glucose concentration.
31	9287058	That only POR(UPS) resulted in a significant suppression of the sympathoadrenal response is consistent with the localization of the glucosensors to the portal vein.
32	9287058	Animals were exposed to one of three protocols distinguished by the site of glucose infusion: POR(UPS), POR(ADJ), or peripheral (PER).
33	9287058	By design, hepatic glucose was significantly elevated during POR(UPS) and POR(ADJ) versus PER (4.3 +/- 0.1 vs. 2.4 +/- 0.1 mmol/l, respectively; P < 0.05).
34	9287058	When portohepatic normoglycemia was maintained during POR(UPS), a 67% suppression in the epinephrine response versus that during PER was observed (P < 0.001).
35	9287058	While both POR(UPS) and POR(ADJ) yielded elevated liver glycemia in the face of systemic hypoglycemia, only POR(UPS) yielded an elevated portal vein glucose concentration.
36	9287058	That only POR(UPS) resulted in a significant suppression of the sympathoadrenal response is consistent with the localization of the glucosensors to the portal vein.
37	9287058	Animals were exposed to one of three protocols distinguished by the site of glucose infusion: POR(UPS), POR(ADJ), or peripheral (PER).
38	9287058	By design, hepatic glucose was significantly elevated during POR(UPS) and POR(ADJ) versus PER (4.3 +/- 0.1 vs. 2.4 +/- 0.1 mmol/l, respectively; P < 0.05).
39	9287058	When portohepatic normoglycemia was maintained during POR(UPS), a 67% suppression in the epinephrine response versus that during PER was observed (P < 0.001).
40	9287058	While both POR(UPS) and POR(ADJ) yielded elevated liver glycemia in the face of systemic hypoglycemia, only POR(UPS) yielded an elevated portal vein glucose concentration.
41	9287058	That only POR(UPS) resulted in a significant suppression of the sympathoadrenal response is consistent with the localization of the glucosensors to the portal vein.
42	16085039	We sought to identify candidate control genes by analyzing seven functionally distinct housekeeping genes (B2M, GAPDH, HMBS, HPRT, SDHA, TBP, YWHAZ) for their expression stability and level in the placenta. mRNA isolated from 20 placentae was analyzed for gene expression using RT-PCR.
43	16085039	TBP and SDHA were the most stable, with an average expression stability of M = 0.43, followed by YWHAZ (M = 0.44) > HPRT (M = 0.53) > HMBS (M = 0.57) > GAPDH (M = 0.61) > B2M (M = 0.69).
44	16085039	By using TBP, SDHA and YWHAZ, with greater expression stability than those housekeeping genes commonly used in placenta studies, gene expression profile comparisons will have more sensitivity and specificity.
45	16085039	We sought to identify candidate control genes by analyzing seven functionally distinct housekeeping genes (B2M, GAPDH, HMBS, HPRT, SDHA, TBP, YWHAZ) for their expression stability and level in the placenta. mRNA isolated from 20 placentae was analyzed for gene expression using RT-PCR.
46	16085039	TBP and SDHA were the most stable, with an average expression stability of M = 0.43, followed by YWHAZ (M = 0.44) > HPRT (M = 0.53) > HMBS (M = 0.57) > GAPDH (M = 0.61) > B2M (M = 0.69).
47	16085039	By using TBP, SDHA and YWHAZ, with greater expression stability than those housekeeping genes commonly used in placenta studies, gene expression profile comparisons will have more sensitivity and specificity.
48	17052186	We showed that UBB+1 causes UPS dysfunction, aggregation and apoptotic cell death.
49	17118805	The interaction of PPARs with the ubiquitin-proteasome system (UPS) has been the subject of limited investigation.
50	17118805	This review highlights the current knowledge regarding the interactions of the UPS with PPARs and focuses on the differential regulation of the level and activity of the PPAR isotypes by the UPS in response to selective ligands.
51	17118805	Understanding the connections between the UPS and PPARs can provide insights in the actions of existing drugs and raise the possibilities for development of more effective PPAR-based therapeutics.
52	17118805	The interaction of PPARs with the ubiquitin-proteasome system (UPS) has been the subject of limited investigation.
53	17118805	This review highlights the current knowledge regarding the interactions of the UPS with PPARs and focuses on the differential regulation of the level and activity of the PPAR isotypes by the UPS in response to selective ligands.
54	17118805	Understanding the connections between the UPS and PPARs can provide insights in the actions of existing drugs and raise the possibilities for development of more effective PPAR-based therapeutics.
55	18551186	Here we review the current knowledge of the interactions between the UPS and PPARs in light of the potential implications for their effects on cell fate and tumorigenesis.
56	23246353	To shed light on islet cell molecular phenotype in human type 2 diabetes (T2D), we studied the transcriptome of non-diabetic (ND) and T2D islets to then focus on the ubiquitin-proteasome system (UPS), the major protein degradation pathway.
57	23246353	Quantitative RT-PCR demonstrated downregulation of selected UPS genes in T2D islets and beta cell fractions, with greater ubiquitin accumulation and reduced proteasome activity.
58	23246353	To shed light on islet cell molecular phenotype in human type 2 diabetes (T2D), we studied the transcriptome of non-diabetic (ND) and T2D islets to then focus on the ubiquitin-proteasome system (UPS), the major protein degradation pathway.
59	23246353	Quantitative RT-PCR demonstrated downregulation of selected UPS genes in T2D islets and beta cell fractions, with greater ubiquitin accumulation and reduced proteasome activity.