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Gene Information

Gene symbol: HSD17B11

Gene name: hydroxysteroid (17-beta) dehydrogenase 11

HGNC ID: 22960

Synonyms: RetSDR2, 17-BETA-HSD11, 17-BETA-HSDXI, PAN1B, SDR16C2

Related Genes

#	Gene Symbol	Number of hits
1	NR3C2	1 hits
2	SPAG8	1 hits

Related Sentences

#	PMID	Sentence
1	7559888	Alterations in cortisol metabolism in insulin-dependent diabetes mellitus: relationship with metabolic control and estimated blood volume and effect of angiotensin-converting enzyme inhibition.
2	7559888	11 beta-Hydroxysteroid dehydrogenase (11 beta HSD) catalyzes the interconversion of cortisol and its inactive metabolite, cortisone, and protects the mineralocorticoid receptor from activation by cortisol.
3	7559888	Sodium and fluid retention is a well documented phenomenon in insulin-dependent diabetes mellitus (IDDM), but it is not known whether diabetes-associated alterations in cortisol metabolism contribute to its pathogenesis.
4	7559888	In seven microalbuminuric IDDM patients, the angiotensin-converting enzyme inhibitor, enalapril (10 mg daily for 6-12 weeks), resulted in a moderate further lowering of the cortisol to cortisone metabolite ratio (P < 0.05).
5	12501657	There are two types of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD). 11 beta-HSD 1 is an oxoreductase interconverting biologically active cortisol and inactive cortisone. 11 beta-HSD 2 is an exclusive oxidase only converting cortisol to cortisone.
6	20347978	Intracellular GC levels are regulated by 11β-hydroxysteroid dehydrogenase (11β-HSD1) which converts inactive cortisone to cortisol, thereby increasing local GC action.