Ignet

Gene Information

Gene symbol: HSPG2

Gene name: heparan sulfate proteoglycan 2

HGNC ID: 5273

Synonyms: perlecan, PRCAN

Related Genes

#	Gene Symbol	Number of hits
1	AAVS1	1 hits
2	ACTB	1 hits
3	ALB	1 hits
4	ALPI	1 hits
5	APLP2	1 hits
6	APOB	1 hits
7	APOE	1 hits
8	BRCA1	1 hits
9	CCL2	1 hits
10	CD44	1 hits
11	CDKN1C	1 hits
12	COL1A1	1 hits
13	COL4A4	1 hits
14	CSF1	1 hits
15	DCN	1 hits
16	DDIT3	1 hits
17	DYNC1H1	1 hits
18	FOS	1 hits
19	GPR180	1 hits
20	HIST1H2BO	1 hits
21	HIST2H2BE	1 hits
22	HPSE	1 hits
23	IAPP	1 hits
24	IDDM2	1 hits
25	IDS	1 hits
26	IGF1	1 hits
27	IGFALS	1 hits
28	IGFBP2	1 hits
29	IL2	1 hits
30	IL6	1 hits
31	IL8	1 hits
32	INS	1 hits
33	LDLR	1 hits
34	LPL	1 hits
35	MDK	1 hits
36	MLLT3	1 hits
37	MMP2	1 hits
38	MMP9	1 hits
39	NPHS1	1 hits
40	PRKCA	1 hits
41	PRKCB1	1 hits
42	SDC1	1 hits
43	SDC2	1 hits
44	SERPINC1	1 hits
45	SLC9A3R2	1 hits
46	SMARCA1	1 hits
47	SMC3	1 hits
48	TGFB1	1 hits
49	TIMP2	1 hits
50	TP63	1 hits

Related Sentences

#	PMID	Sentence
1	7527876	At 12 months albuminuria, renal collagen IV and perlecan mRNA levels, anionic and neutral dextran clearances, glomerular basement membrane morphometry, and mesangial cell proliferation were evaluated.
2	8638427	The ubiquitous BM-constituent collagen IV primarily stabilizes the BM-zone and thus represents the "backbone" of the BM providing mechanical strength.
3	8638427	The specific localization of collagen VII as the main structural component of anchoring fibrils underlines the mechanical anchoring function of this collagenous protein.
4	8638427	The rapid re-occurrence of epidermal collagen VII during normal human wound healing indicates a quick reconstitution of the mechanical tensile strength of healing wounds. 3.)
5	8638427	The BM-specific heparan sulfate proteoglycan (HSPG, Perlecan) with its highly negative anionic charge can be assumed to exert filter control.
6	8638427	In further analyses of diabetic glomerulopathy, we provide evidence for an extensive matrix dysregulation resulting in either the overexpression of certain BM-components (diffuse glomerulosclerosis) or microfibrillar collagen VI (nodular glomerulosclerosis) indicating changes in cell function and possibly also cellular "differentiation".
7	8985139	In some DR corneas, epithelial BM was stained discontinuously for laminin-1, entactin/nidogen, and alpha3-alpha4 Type IV collagen, in contrast to non-DR corneas.
8	8985139	In preretinal membranes, perlecan, bamacan, and Types VI, VIII, XII, and XIV collagen were newly identified.
9	9032395	The Rep proteins of adeno-associated virus type 2 (AAV) are known to bind to Rep recognition sequences (RRSs) in the AAV inverted terminal repeats (ITRs), the AAV p5 promoter, and the preferred AAV integration site in human chromosome 19, called AAVS1.
10	9032395	We used the 16-mer core sequences of the RRSs in the AAV ITRs and AAVS1 separately as query sequences and identified 18 new RRSs in or flanking the genes coding for the following: tyrosine kinase activator protein 1 (TKA-1); colony stimulating factor-1; insulin-like growth factor binding protein 2 (IGFBP-2); histone H2B.1; basement membrane heparan sulfate proteoglycan, also known as perlecan; the AF-9 gene product, which is involved in the chromosomal translocation t (9:11)(p22:q23); the betaB subunit of the hormone known as inhibin; interleukin-2 enhancer binding factor; an endoplasmic reticulum-Golgi intermediate compartment resident protein called p63; a global transcription activator (hSNF2L); the beta-actin repair domain; a retinoic acid-inducible factor, also known as midkine; a breast tumor autoantigen; a growth-arrest- and DNA-damage-inducible protein called gadd45; the cyclin-dependent kinase inhibitor called KIP2, which inhibits several G1 cyclin-cyclin-dependent kinase complexes; and the hereditary breast and ovarian cancer gene (BRCA1).
11	9313766	Genetic variation of the heparan sulfate proteoglycan gene (perlecan gene).
12	9568695	Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation.
13	9568695	Previous studies have also revealed the presence of the specific heparan sulfate proteoglycan, perlecan, colocalized to islet amyloid deposits, similar to perlecan's known involvement with other amyloid proteins.
14	9568695	In the present study, perlecan purified from the Engelbreth-Holm-Swarm (EHS) tumor was used to define perlecan's interactions with amylin (i.e., islet amyloid polypeptide) and its effects on amylin fibril formation.
15	9568695	Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation.
16	9568695	Previous studies have also revealed the presence of the specific heparan sulfate proteoglycan, perlecan, colocalized to islet amyloid deposits, similar to perlecan's known involvement with other amyloid proteins.
17	9568695	In the present study, perlecan purified from the Engelbreth-Holm-Swarm (EHS) tumor was used to define perlecan's interactions with amylin (i.e., islet amyloid polypeptide) and its effects on amylin fibril formation.
18	9568695	Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation.
19	9568695	Previous studies have also revealed the presence of the specific heparan sulfate proteoglycan, perlecan, colocalized to islet amyloid deposits, similar to perlecan's known involvement with other amyloid proteins.
20	9568695	In the present study, perlecan purified from the Engelbreth-Holm-Swarm (EHS) tumor was used to define perlecan's interactions with amylin (i.e., islet amyloid polypeptide) and its effects on amylin fibril formation.
21	10334297	It has as its unique component the islet beta-cell peptide islet amyloid polypeptide (IAPP), or amylin, which is cosecreted with insulin.
22	10334297	In addition to this unique component, islet amyloid contains other proteins, such as apolipoprotein E and the heparan sulfate proteoglycan perlecan, which are typically observed in other forms of generalized and localized amyloid.
23	10512360	Two novel immortal pancreatic beta-cell lines expressing and secreting human islet amyloid polypeptide do not spontaneously develop islet amyloid.
24	10512360	Type 2 diabetes is characterized by islet amyloid deposits, which are primarily composed of the amyloidogenic human form of islet amyloid polypeptide (IAPP, amylin).
25	10512360	The mechanism of islet amyloido-genesis is not known, but other products (e.g., apolipoprotein E and perlecan) contained within islet amyloid may be necessary.
26	10586428	Recently, a BamHI restriction fragment length polymorphism (RFLP) in the HSPG gene (HSPG2) was reported to be associated with diabetic nephropathy in Caucasian insulin-dependent diabetes mellitus (IDDM).
27	10586428	The aim of the present study was to examine the contribution of the BamHI HSPG2 polymorphism to the development of diabetic nephropathy in Japanese non-insulin-dependent diabetes mellitus (NIDDM).
28	10586428	Recently, a BamHI restriction fragment length polymorphism (RFLP) in the HSPG gene (HSPG2) was reported to be associated with diabetic nephropathy in Caucasian insulin-dependent diabetes mellitus (IDDM).
29	10586428	The aim of the present study was to examine the contribution of the BamHI HSPG2 polymorphism to the development of diabetic nephropathy in Japanese non-insulin-dependent diabetes mellitus (NIDDM).
30	10818109	Perlecan heparan sulfate proteoglycan: a novel receptor that mediates a distinct pathway for ligand catabolism.
31	10818109	Cells expressing perlecan but no other proteoglycans bound, internalized, and degraded atherogenic lipoproteins enriched in lipoprotein lipase.
32	10818109	By several criteria, catabolism via perlecan was distinct from either coated pits or the syndecan pathway.
33	10818109	Blockade of the low density lipoprotein receptor-related protein did not slow perlecan-dependent internalization.
34	10818109	Internalization via perlecan was inhibited by genistein but unaffected by cytochalasin D, a pattern distinct from coated pits or syndecan-mediated endocytosis.
35	10818109	Perlecan heparan sulfate proteoglycan: a novel receptor that mediates a distinct pathway for ligand catabolism.
36	10818109	Cells expressing perlecan but no other proteoglycans bound, internalized, and degraded atherogenic lipoproteins enriched in lipoprotein lipase.
37	10818109	By several criteria, catabolism via perlecan was distinct from either coated pits or the syndecan pathway.
38	10818109	Blockade of the low density lipoprotein receptor-related protein did not slow perlecan-dependent internalization.
39	10818109	Internalization via perlecan was inhibited by genistein but unaffected by cytochalasin D, a pattern distinct from coated pits or syndecan-mediated endocytosis.
40	10818109	Perlecan heparan sulfate proteoglycan: a novel receptor that mediates a distinct pathway for ligand catabolism.
41	10818109	Cells expressing perlecan but no other proteoglycans bound, internalized, and degraded atherogenic lipoproteins enriched in lipoprotein lipase.
42	10818109	By several criteria, catabolism via perlecan was distinct from either coated pits or the syndecan pathway.
43	10818109	Blockade of the low density lipoprotein receptor-related protein did not slow perlecan-dependent internalization.
44	10818109	Internalization via perlecan was inhibited by genistein but unaffected by cytochalasin D, a pattern distinct from coated pits or syndecan-mediated endocytosis.
45	10818109	Perlecan heparan sulfate proteoglycan: a novel receptor that mediates a distinct pathway for ligand catabolism.
46	10818109	Cells expressing perlecan but no other proteoglycans bound, internalized, and degraded atherogenic lipoproteins enriched in lipoprotein lipase.
47	10818109	By several criteria, catabolism via perlecan was distinct from either coated pits or the syndecan pathway.
48	10818109	Blockade of the low density lipoprotein receptor-related protein did not slow perlecan-dependent internalization.
49	10818109	Internalization via perlecan was inhibited by genistein but unaffected by cytochalasin D, a pattern distinct from coated pits or syndecan-mediated endocytosis.
50	10818109	Perlecan heparan sulfate proteoglycan: a novel receptor that mediates a distinct pathway for ligand catabolism.
51	10818109	Cells expressing perlecan but no other proteoglycans bound, internalized, and degraded atherogenic lipoproteins enriched in lipoprotein lipase.
52	10818109	By several criteria, catabolism via perlecan was distinct from either coated pits or the syndecan pathway.
53	10818109	Blockade of the low density lipoprotein receptor-related protein did not slow perlecan-dependent internalization.
54	10818109	Internalization via perlecan was inhibited by genistein but unaffected by cytochalasin D, a pattern distinct from coated pits or syndecan-mediated endocytosis.
55	10862796	Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice.
56	10862796	Delayed clearance of postprandial apoB-48-containing lipoproteins in DM appears to be due to decreased hepatic perlecan HSPG.
57	11122703	In smooth muscle cells, NEFA-albumin complex increased the expression of the genes for the core proteins of the proteoglycans syndecan, decorin and perlecan.
58	11145957	Identification of a heparin binding domain in the N-terminal cleavage site of pro-islet amyloid polypeptide.
59	11145957	Islet amyloid deposits are a characteristic pathologic lesion of the pancreas in type 2 diabetes and are composed primarily of the islet beta cell peptide islet amyloid polypeptide (IAPP or amylin) as well as the basement membrane heparan sulfate proteoglycan perlecan.
60	11150731	Atherogenic levels of low-density lipoprotein (LDL), oxidized LDL and lysolecithin decrease not only perlecan core protein synthesis but also enhance heparan sulfate degradation by stimulating endothelial secretion of heparanase.
61	11150731	ApoE and apoE-HDL, in contrast, increase perlecan core protein as well as sulfation of heparan sulfate.
62	11150731	Increased perlecan in endothelial cells was associated with increased antithrombin-binding and antiproliferative heparan sulfates.
63	11150731	Atherogenic levels of low-density lipoprotein (LDL), oxidized LDL and lysolecithin decrease not only perlecan core protein synthesis but also enhance heparan sulfate degradation by stimulating endothelial secretion of heparanase.
64	11150731	ApoE and apoE-HDL, in contrast, increase perlecan core protein as well as sulfation of heparan sulfate.
65	11150731	Increased perlecan in endothelial cells was associated with increased antithrombin-binding and antiproliferative heparan sulfates.
66	11150731	Atherogenic levels of low-density lipoprotein (LDL), oxidized LDL and lysolecithin decrease not only perlecan core protein synthesis but also enhance heparan sulfate degradation by stimulating endothelial secretion of heparanase.
67	11150731	ApoE and apoE-HDL, in contrast, increase perlecan core protein as well as sulfation of heparan sulfate.
68	11150731	Increased perlecan in endothelial cells was associated with increased antithrombin-binding and antiproliferative heparan sulfates.
69	11757076	Perlecan, a member of the heparan sulfate proteoglycan (HSPG) family, has been implicated in many complications of diabetes.
70	12137765	The whole choroids were dissected from the sclera, fixed in 2% paraformaldehyde and processed for immunohistochemical demonstration of perlecan, a heparan sulfate proteoglycan, using a streptavidin alkaline phosphatase technique.
71	15056491	High-glucose-induced structural changes in the heparan sulfate proteoglycan, perlecan, of cultured human aortic endothelial cells.
72	15149955	The lysosomal enzyme iduronate-2-sulfatase (IDS) is expressed in pancreatic islets and is responsible for degradation of proteoglycans, such as perlecan and dermatan sulfate.
73	15149955	Neither insulin content nor secretory response to glucose (16.7 mM) was altered in mouse islets infected with lentiviral constructs carrying the IDS gene in sense orientation.
74	15149955	However, insulin content was reduced (35% vs. controls, P < 0.001) in islets infected with IDS antisense construct, while the secretory response of those islets to glucose was maintained.
75	15149955	Inhibition of IDS by antisense infection led to an increase in lysosomal size and a high rate of insulin granule degradation via the crinophagic route in pancreatic beta-cells.
76	15277392	The hyperglycemia-induced downregulation of the negatively charged basement membrane heparan sulfate proteoglycan perlecan was completely prevented in the PKC-alpha(-/-) mice, compared with controls.
77	15277392	We then asked whether transforming growth factor-beta1 (TGF-beta1) and/or vascular endothelial growth factor (VEGF) is implicated in the PKC-alpha-mediated changes in the basement membrane.
78	15277392	The hyperglycemia-induced expression of VEGF165 and its receptor VEGF receptor II (flk-1) was ameliorated in PKC-alpha(-/-) mice, whereas expression of TGF-beta1 was not affected by the lack of PKC-alpha.
79	15277392	The glucose-induced albuminuria seems to be mediated by PKC-alpha via downregulation of proteoglycans in the basement membrane and regulation of VEGF expression.
80	15449170	To examine the effects of glucose and advanced glycosylated end-products (AGE) on perlecan, we cultured rat glomerular epithelial cells (GEpC) on AGE- or bovine serum albumin (BSA)-coated plates under normal (NG, 5 mM) and high-glucose (HG, 30 mM) conditions and measured the change in perlecan core protein production by a sandwich ELISA and northern blot analysis.
81	16207378	Incubation of endothelial cells with glucosamine, but not glucose, significantly increased matrix HSPG (perlecan) containing heparin-like sequences.
82	16207378	The antiproliferative effect of glucosamine was mediated via induction of perlecan HSPG.
83	16207378	Incubation of endothelial cells with glucosamine, but not glucose, significantly increased matrix HSPG (perlecan) containing heparin-like sequences.
84	16207378	The antiproliferative effect of glucosamine was mediated via induction of perlecan HSPG.
85	16226129	Perlecan was also found to co-localize with laminin and collagen IV in the basement membranes of placenta.
86	16630654	Immunohistochemistry indicated intensive staining of decorin and biglycan in the diabetic placenta with different localizations.
87	16630654	Additionally, the basement membrane HSPG, perlecan was found to contain both CS/DS and HS in GDM placentas and plain HS in controls.
88	16866369	Characterization of the heparin binding site in the N-terminus of human pro-islet amyloid polypeptide: implications for amyloid formation.
89	16866369	Islet amyloid polypeptide (IAPP), also referred to as amylin, aggregates in the islet extracellular space to form amyloid deposits in up to 95% of patients with the disease.
90	16866369	IAPP is stored with insulin in beta-islet cells and is processed in parallel by subtilisin-like prohormone convertases prior to secretion.
91	16866369	Immunohistochemical studies implicate the presence of the heparan sulfate proteoglycan (HSPG) perlecan in islet amyloid deposits, suggesting a role for HSPGs in mediating amyloid deposition in type 2 diabetes and implicating a binding domain in the N-terminus of proIAPP.
92	17259378	The protein kinase C (PKC)-beta isoform has been implicated to play a pivotal role in the development of diabetic kidney disease.
93	17259378	After 8 weeks of diabetes, the high-glucose-induced renal and glomerular hypertrophy, as well as the increased expression of extracellular matrix proteins such as collagen and fibronectin, was reduced in PKC-beta(-/-) mice.
94	17259378	Furthermore, the high-glucose-induced expression of the profibrotic cytokine transforming growth factor (TGF)-beta1 and connective tissue growth factor were significantly diminished in the diabetic PKC-beta(-/-) mice compared with diabetic wild-type mice, suggesting a role of the PKC-beta isoform in the regulation of renal hypertrophy.
95	17259378	Notably, increased urinary albumin-to-creatinine ratio persisted in the diabetic PKC-beta(-/-) mice.
96	17259378	The loss of the basement membrane proteoglycan perlecan and the podocyte protein nephrin in the diabetic state was not prevented in the PKC-beta(-/-) mice as previously demonstrated in the nonalbuminuric diabetic PKC-alpha(-/-) mice.
97	17259378	In summary, the differential effects of PKC-beta deficiency on diabetes-induced renal hypertrophy and albuminuria suggest that PKC-beta contributes to high-glucose-induced TGF-beta1 expression and renal fibrosis, whereas perlecan, as well as nephrin, expression and albuminuria is regulated by other signaling pathways.
98	17259378	The protein kinase C (PKC)-beta isoform has been implicated to play a pivotal role in the development of diabetic kidney disease.
99	17259378	After 8 weeks of diabetes, the high-glucose-induced renal and glomerular hypertrophy, as well as the increased expression of extracellular matrix proteins such as collagen and fibronectin, was reduced in PKC-beta(-/-) mice.
100	17259378	Furthermore, the high-glucose-induced expression of the profibrotic cytokine transforming growth factor (TGF)-beta1 and connective tissue growth factor were significantly diminished in the diabetic PKC-beta(-/-) mice compared with diabetic wild-type mice, suggesting a role of the PKC-beta isoform in the regulation of renal hypertrophy.
101	17259378	Notably, increased urinary albumin-to-creatinine ratio persisted in the diabetic PKC-beta(-/-) mice.
102	17259378	The loss of the basement membrane proteoglycan perlecan and the podocyte protein nephrin in the diabetic state was not prevented in the PKC-beta(-/-) mice as previously demonstrated in the nonalbuminuric diabetic PKC-alpha(-/-) mice.
103	17259378	In summary, the differential effects of PKC-beta deficiency on diabetes-induced renal hypertrophy and albuminuria suggest that PKC-beta contributes to high-glucose-induced TGF-beta1 expression and renal fibrosis, whereas perlecan, as well as nephrin, expression and albuminuria is regulated by other signaling pathways.
104	17554150	Significantly reduced expression of TGF-beta, vascular endothelial growth factor, and collagen IV was found in glomeruli and the tubulointerstitial area with CERA treatment, and these beneficial molecular effects were clearly dosage dependent (both P < 0.05 versus placebo).
105	17554150	Similarly, CERA treatment caused a dosage-dependent increase in p-Akt, nephrin, and perlecan tissue expression (all P < 0.05 versus placebo).
106	18291521	Members of this family in the human placenta and decidua that act principally in linking to collagen IV and laminin networks include perlecan, agrin, and collagen XVIII, each of which have characteristic locations.
107	18291521	Perlecan is widely expressed in trophoblasts, the villous and endothelial basement membranes, villous stroma, and decidua, whereas collagen XVIII is not expressed in trophoblasts.
108	18291521	Members of this family in the human placenta and decidua that act principally in linking to collagen IV and laminin networks include perlecan, agrin, and collagen XVIII, each of which have characteristic locations.
109	18291521	Perlecan is widely expressed in trophoblasts, the villous and endothelial basement membranes, villous stroma, and decidua, whereas collagen XVIII is not expressed in trophoblasts.
110	22484878	Perlecan (basement membrane heparan sulfate proteoglycan) and its role in oral malignancies: an overview.
111	23757342	Immunohistochemical staining for the heparan sulfate proteoglycan perlecan was similar in both types of material but reduced staining of 4-O-sulfated chondroitin and dermatan was observed in kidney sections from diabetic mice.
112	23983782	Results showed that the hyperglycemia-induced GAG alterations in the cell surface perlecan as well as in the ECM indeed upregulated the expressions of IL-6, IL-8, and MCP-1 and the activities of MMP-2 and MMP-9 and downregulated the expressions of TIMP-2.