Ignet

Gene Information

Gene symbol: IBSP

Gene name: integrin-binding sialoprotein

HGNC ID: 5341

Synonyms: BSP, SP-II, BSP-II

Related Genes

#	Gene Symbol	Number of hits
1	ALPI	1 hits
2	ALPP	1 hits
3	BGLAP	1 hits
4	BMP4	1 hits
5	BMP7	1 hits
6	COL1A1	1 hits
7	COL1A2	1 hits
8	DMP1	1 hits
9	INS	1 hits
10	MMP9	1 hits
11	NR0B2	1 hits
12	PHEX	1 hits
13	RUNX2	1 hits
14	SP7	1 hits
15	SPP1	1 hits
16	TNFRSF11B	1 hits

Related Sentences

#	PMID	Sentence
1	17056676	We examined the effects of insulin on calcifying smooth muscle cells in vitro and measured the expression of the bone-related molecule osteoprotegerin (OPG).
2	17056676	Histochemistry was used for determination of alkaline phosphatase (ALP).
3	17056676	Bone sialoprotein (BSP) and OPG mRNA expressions were done by RT-PCR. beta-Glycerophosphate was able to induce calcification in human smooth muscle cells from a series of donors after variable time in culture.
4	17056676	Calcified cells expressed ALP and BSP activity in high levels.
5	17056676	Effects of insulin and modulations by OPG on the calcification process in arterial cells may play a role in the development of calcifications as part of the diabetic macroangiopathy.
6	17056676	We examined the effects of insulin on calcifying smooth muscle cells in vitro and measured the expression of the bone-related molecule osteoprotegerin (OPG).
7	17056676	Histochemistry was used for determination of alkaline phosphatase (ALP).
8	17056676	Bone sialoprotein (BSP) and OPG mRNA expressions were done by RT-PCR. beta-Glycerophosphate was able to induce calcification in human smooth muscle cells from a series of donors after variable time in culture.
9	17056676	Calcified cells expressed ALP and BSP activity in high levels.
10	17056676	Effects of insulin and modulations by OPG on the calcification process in arterial cells may play a role in the development of calcifications as part of the diabetic macroangiopathy.
11	18162513	Runt-related transcription factor 2 (RUNX2), and several RUNX2 target genes, including matrix metalloproteinase-9, Akp2, integrin binding sialoprotein, Dmp1, Col1a2, Phex, Vdr, osteocalcin, and osterix, were all significantly down-regulated in the insulin-deficient, hyperglycemic diabetic animals; however, insulin treatment of diabetic animals significantly restored their expression.
12	18162513	Expression of bone morphogenic protein-2, transcriptional coactivator with PDZ-binding motif, and TWIST2, all important regulators of RUNX2, were not impacted by the diabetic condition, suggesting that the defect in osteogenesis resides at the level of RUNX2 expression and its activity.
13	21147283	Metformin induces osteoblast differentiation via orphan nuclear receptor SHP-mediated transactivation of Runx2.
14	21147283	Metformin increased significantly the expression of the key osteogenic genes, such as alkaline phosphatase (ALP), osteocalcin (OC) and bone sialoprotein (BSP) as well as SHP.
15	21147283	Transient transfection assays were performed in MC3T3E1 cells to confirm the effects of metformin on SHP, OC and Runx2 promoter activities.
16	21147283	Metformin increased the transcription of the SHP and OC genes, and the metformin effect was inhibited by dominant negative form of AMPK (DN-AMPK) or compound C (an inhibitor of AMPK).
17	21147283	The adenoviral overexpression of SHP increased significantly the level of ALP staining and OC production.
18	21147283	However, metformin did not have any significant effect on osteogenic gene expression, ALP staining and activity, and OC production in SHP null (SHP-/-) primary calvarial cells.
19	21147283	Moreover, upstream stimulatory factor-1 (USF-1) specifically mediated metformin-induced SHP gene expression.
20	21147283	In addition, metformin-induced AMPK activation increased the level of Runx2 mRNA and protein.
21	21147283	However, USF-1 and SHP were not involved in metformin-induced Runx2 expression.
22	21147283	Transient transfection and chromatin immunoprecipitation assays confirmed that metformin-induced SHP interacts physically and forms a complex with Runx2 on the osteocalcin gene promoter in MC3T3E1 cells.
23	21147283	These results suggest that metformin may stimulate osteoblast differentiation through the transactivation of Runx2 via AMPK/USF-1/SHP regulatory cascade in mouse calvaria-derived cells.
24	23652775	In addition, treatment with CZE resulted in a significant increase in alkaline phosphatase (ALP) activity and collagen content, as well as in the expression of genes associated with osteoblast differentiation [ALP, collagen, osteopontin (OPN), osteoprotegerin (OPG), bone sialoprotein (BSP), osteocalcin (OC) and bone morphogenetic protein (BMP)2, BMP4 and BMP7].
25	23652775	In mechanistic studies of the antioxidative potential of CZE, we found that CZE reversed the dRib-induced decrease in the expression of phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT)1 and AKT2 genes, which are master regulators of survival-related signaling pathways.
26	23652775	CZE also upregulated the gene expression of the antioxidant enzymes, superoxide dismutase (SOD)2, SOD3 and glutathione peroxidase 4 (GPx4), which was inhibited by dRib.