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Gene Information
Gene symbol: IFNAR2
Gene name: interferon (alpha, beta and omega) receptor 2
HGNC ID: 5433
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IFNAR1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23129613 | Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies. |
| 2 | 23129613 | Type 1 interferons (IFN1) elicit antiviral defenses by activating the cognate receptor composed of IFN-α/β receptor chain 1 (IFNAR1) and IFNAR2. |
| 3 | 23129613 | Down-regulation of this receptor occurs through IFN1-stimulated IFNAR1 ubiquitination, which exposes a Y466-based linear endocytic motif within IFNAR1 to recruitment of the adaptin protein-2 complex (AP2) and ensuing receptor endocytosis. |
| 4 | 23129613 | To explain how IFN1 promotes Y466 phosphorylation yet stimulates IFNAR1 internalization, we proposed that the activity of a protein tyrosine phosphatase (PTP) is required to enable both events by dephosphorylating Y466. |
| 5 | 23129613 | An RNAi-based screen identified PTP1B as a specific regulator of IFNAR1 endocytosis stimulated by IFN1, but not by ligand-independent inducers of IFNAR1 ubiquitination. |
| 6 | 23129613 | PTP1B is capable of binding and dephosphorylating IFNAR1. |
| 7 | 23129613 | Genetic or pharmacologic modulation of PTP1B activity regulated IFN1 signaling in a manner dependent on the integrity of Y466 within IFNAR1 in human cells. |