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Gene Information

Gene symbol: IFT88

Gene name: intraflagellar transport 88 homolog (Chlamydomonas)

HGNC ID: 20606

Synonyms: hTg737, Tg737, D13S1056E, MGC26259

Related Genes

#	Gene Symbol	Number of hits
1	BBS7	1 hits
2	PRKD1	1 hits
3	TTC8	1 hits

Related Sentences

#	PMID	Sentence
1	15226261	Here we show that in orpk mice, a model system for PKD that harbors a mutation in the gene that encodes the polaris protein, pancreatic defects start to occur at the end of gestation, with an initial expansion of the developing pancreatic ducts.
2	15226261	Expression of polycystin-2, a protein involved in PKD, is mislocalized in orpk mice.
3	15226261	Furthermore, the cellular localization of beta-catenin, a protein involved in cell adhesion and Wnt signaling, is altered.
4	15231740	Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.
5	15231740	Here, we show that mutations in the Caenorhabditis elegans bbs-7 and bbs-8 genes cause structural and functional defects in cilia.
6	15231740	Importantly, we demonstrate that BBS-7 and BBS-8 are required for the normal localization/motility of the IFT proteins OSM-5/Polaris and CHE-11, and to a notably lesser extent, CHE-2.
7	19276629	Indeed, hypomorphic mutations in the mouse ift88 (previously called Tg737) gene, which encodes a ciliogenic intraflagellar transport protein, result in malformation of primary cilia, and in the collecting ducts of kidney tubules this is accompanied by development of autosomal recessive polycystic kidney disease (PKD).