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Gene Information
Gene symbol: IGKV2-23
Gene name: immunoglobulin kappa variable 2-23
HGNC ID: 5780
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | C21orf63 | 1 hits |
| 2 | HPT | 1 hits |
| 3 | IDDM2 | 1 hits |
| 4 | IGKV1-17 | 1 hits |
| 5 | IGKV6-21 | 1 hits |
| 6 | TNFRSF10A | 1 hits |
| 7 | TNFRSF25 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7806025 | A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population. |
| 2 | 7806025 | In Finland the haplotype A2, Cw1, B56, DR4, DQ8 is the third most common haplotype in insulin-dependent diabetic (IDDM) patients and has the highest haplotype-specific absolute risk for IDDM. |
| 3 | 7806025 | Cw1, B56, DR4, DQ8 haplotypes containing HLA-A alleles other than A2 are infrequent in the population and are not associated with IDDM. |
| 4 | 7806025 | Evidence that class I alleles confer susceptibility to IDDM was obtained from the two HLA-C, -B, -DR and -DQ haplotypes most frequently found in IDDM patients in Finland. |
| 5 | 7806025 | A24, A3 and A2 on the Cw3, B62, DR4, DQ8 haplotype, and A28, A2 and A1 on the Cw7, B8, DR3, DQ2 were all found to be associated with IDDM. |
| 6 | 7806025 | Significantly more non-DR3/non-DR4 IDDM patients (47 of 55) possessed two of the IDDM-associated HLA-A alleles compared to non-DR3/non-DR4 control subjects (40 of 58; p = 0.038). |
| 7 | 7806025 | Moreover, IDDM patients confirmed by oligotyping as unable to form a 'diabetes-susceptibility' DQ heterodimer, tended to possess two diabetes-associated HLA-A alleles (12 of 13) compared to control subjects (12 of 20; p = 0.056). |
| 8 | 8977763 | Hypoparathyroidism and insulin-dependent diabetes mellitus in a patient with Kearns-Sayre syndrome harbouring a mitochondrial DNA deletion. |
| 9 | 8977763 | She also had insulin-dependent diabetes mellitus (IDDM). |
| 10 | 8977763 | Human leucocyte associated antigen typing showed A24, A26; B54, B61; CW1, CW3; DR8, DR14; DQ1 and DQ3, suggesting that the presence of HLA-A24 and CW3 antigen contributed to the association of IDDM and hypoparathyroidism, similar to Japanese patients with polyglandular autoimmune syndrome, complicated by hypoparathyroidism and IDDM. |
| 11 | 8977763 | This is an extremely rare case of Kearns-Sayre syndrome, presenting in association with IDDM and idiopathic hypoparathyroidism. |
| 12 | 12694582 | Preceding the clinical diagnosis of type I DM is a preclinical stage characterized by autoantibodies to insulin, glutamic acid decarboxylase (GAD) and a tyrosine phosphatase-like molecule (IA-2). |
| 13 | 12694582 | In contrast, the progression to clinical disease appears associated with class I alleles A24, A30 and B18 while A1, A28, B14 and B56 appear negatively associated. |
| 14 | 12694582 | These results are consistent with the view that CD4+ T cells responding to peptides in the context of class 2 molecules are responsible for initiating autoantibody production, while the destruction of islet cells leading to clinical expression of the disease is the function of CD8+ T cells recognizing relevant peptides in the context of class I molecules. |
| 15 | 12843130 | Patients with PAS had significantly higher frequencies of the human leukocyte antigens A24, A31, B8, B51, B62, DR3, and DR4 (relative risk, 2.35, 2.74, 2.47, 7.17, 2.22, 1.94, and 2.46) vs. controls, and for A31, B15, B52, B55, DR2, DR11, and DR13 (relative risk, 2.51, 7.96, 3.99, 5.36, 4.46, 2.89, and 3.26) vs. type 1 diabetes patients without PAS. |
| 16 | 16995591 | He had HLA A24, DR4 and DR53 antigens in common with previously reported cases of DM-NS association. |