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Gene Information
Gene symbol: IGKV2D-29
Gene name: immunoglobulin kappa variable 2D-29
HGNC ID: 5800
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADORA3 | 1 hits |
| 2 | COX8A | 1 hits |
| 3 | GPBAR1 | 1 hits |
| 4 | PLA2G4A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16966336 | This effect was mediated by induction of cyclooxygenase-2 (COX-2) gene expression and production of prostaglandin E2 (PGE2) that in turn transactivated epidermal growth factor receptor (EGFR) and Akt. |
| 2 | 16966336 | In support of this, inhibition of COX-2, EGFR, and Akt prevented the PPARdelta-induced cell growth. |
| 3 | 16966336 | Furthermore, PPARdelta activation or PGE2 treatment induced the phosphorylation of cytosolic phospholipase A2alpha (cPLA2alpha), a key enzyme that releases arachidonic acid (AA) substrate for PG production via COX. |
| 4 | 16966336 | Taken together, these observations reveal that PPARdelta induces COX-2 expression in human cholangiocarcinoma cells and that the COX-2-derived PGE2 further activates PPARdelta through phosphorylation of cPLA2alpha. |
| 5 | 23179047 | Pharmacological receptor binding studies on these GPCR ligand-derivatized AuNPs (2-5 nm in diameter), performed using membranes of mammalian cells stably expressing human A1, A2A, and A3ARs, showed that the desired selectivity was retained with K(i) values (nanomolar) of A3AR agonist 21b and A2AAR antagonists 24 and 26a of 14 (A3), 34 (A2A), and 69 (A2A), respectively. |