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Gene Information
Gene symbol: IL18BP
Gene name: interleukin 18 binding protein
HGNC ID: 5987
Synonyms: IL18BPa
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IFNG | 1 hits |
| 2 | IL18 | 1 hits |
| 3 | IL1B | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14679086 | Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene. |
| 2 | 14679086 | IL-18 is capable of inducing T lymphocyte synthesis of IFNgamma, thereby skewing the T helper response toward a T helper type 1 (Th1) profile. |
| 3 | 14679086 | IL-18 binding protein (IL18BP) neutralizes IL-18 and leads to a reduced Th1 response. |
| 4 | 14679086 | Polymorphisms in IL18BP may affect the activity of IL-18 and the magnitude of the Th1 response and may play a role in the pathogenesis of T1DM. |
| 5 | 14679086 | Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene. |
| 6 | 14679086 | IL-18 is capable of inducing T lymphocyte synthesis of IFNgamma, thereby skewing the T helper response toward a T helper type 1 (Th1) profile. |
| 7 | 14679086 | IL-18 binding protein (IL18BP) neutralizes IL-18 and leads to a reduced Th1 response. |
| 8 | 14679086 | Polymorphisms in IL18BP may affect the activity of IL-18 and the magnitude of the Th1 response and may play a role in the pathogenesis of T1DM. |
| 9 | 14679086 | Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein gene. |
| 10 | 14679086 | IL-18 is capable of inducing T lymphocyte synthesis of IFNgamma, thereby skewing the T helper response toward a T helper type 1 (Th1) profile. |
| 11 | 14679086 | IL-18 binding protein (IL18BP) neutralizes IL-18 and leads to a reduced Th1 response. |
| 12 | 14679086 | Polymorphisms in IL18BP may affect the activity of IL-18 and the magnitude of the Th1 response and may play a role in the pathogenesis of T1DM. |
| 13 | 15870024 | IL-18 is a type 1 pro-inflammatory cytokine with structural similarities to IL-1 and in synergy with IL-12 stimulates IFN-gamma production from T lymphocytes and polarizes development and function of Th1 cells. |
| 14 | 15870024 | Because IL-1, IFN-gamma, and up-regulated Th1-mediated events are involved in the pathogenesis of both human and rodent type 1 diabetes mellitus, we have evaluated the effects of a specific inhibitor of IL-18 (the IL-18bp:FcIg) on the development of accelerated forms of autoimmune diabetes in NOD mice. |
| 15 | 17075045 | By neutralizing IL-18 activity with IL-18 binding protein (IL-18BP), we observed that islets produce bioactive IL-18. |
| 16 | 17075045 | In related studies, IL-18R-deficient splenocytes and macrophages produced 2- to 3-fold greater amounts of IL-18, TNFalpha, macrophage inflammatory protein 1, macrophage inflammatory protein 2, and IFNgamma upon stimulation with Con A, Toll-like receptor 2 agonist, or anti-CD3 antibodies. |
| 17 | 17075045 | Importantly, discrepancies between IL-18- and IL-18R-deficient cells suggest that IL-18Ralpha chain is used by an inflammation-suppressing signal. |
| 18 | 21440322 | Serum interleukin-18 binding protein increases with behavior different from IL-18 in patients with diabetic nephropathy. |